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Development of neurorehabilitation system for severe stroke patients with hand paralysis

Research Project

Project/Area Number 16K01520
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionMeiji University

Principal Investigator

Ono Yumie  明治大学, 理工学部, 専任教授 (10360207)

Research Collaborator TOMINAGA takanori  
ITO naoyoshi  
KITAMURA masatoshi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsブレイン・マシンインターフェース / ニューロフィードバック / 運動感覚 / 脳卒中 / リハビリテーション / ブレイン・マシン・インターフェース
Outline of Final Research Achievements

We developed Digital Mirror Box (DMB), a brain-machine interface-based rehabilitation system that can train the affected motor cortical activity of stroke patients with hand paralysis. DMB detects event-related desynchronizations (ERDs) in the mu band activity derived from hand motor imagery and provides proprioceptive feedback upon successful generation of ERD. Repetitive use of DMB on top of conventional physiotherapy and occupational therapy confirmed the statistically significant decrease in muscle spasticity relative to that obtained during control period. Furthermore, a statistically significant improvement of hand and finger functions (assessed using Fugl-Meyer Assessment) was seen in DMB, but not in the control period. This was associated with a trend in increased ERD power through DMB training period over control period. These results suggest that neurorehabilitation using DMB can ease spasticity and improve hand function via increasing motor-related cortical activity.

Academic Significance and Societal Importance of the Research Achievements

脳卒中患者が残存する脳内の運動経路を訓練し,麻痺した手を動かせるようにするためのリハビリテーション装置を開発した。ブレイン・マシンインターフェースという技術を用い,手の運動を想起するときの脳活動を検出する。うまく想起ができたら,麻痺手に装着したロボットにより麻痺した手に同じ動作をさせる。「動かない手が動く」というフィードバックがあるため,運動機能を回復させるために,どのような脳活動を出力すればよいか確認しながら訓練できるという特長がある。この装置を使うことで手を自発的に動かせるようになった症例も確認され,今後,脳卒中患者の運動機能を効率的に回復させる方法としての活用が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (48 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (15 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 15 results,  Open Access: 9 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Int'l Joint Research: 8 results,  Invited: 5 results) Book (1 results) Remarks (6 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] イェール大学医学部(米国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Differences in Regional Brain Activities during Memory Acquisition Depending on Individual Working Memory Capacity2019

    • Author(s)
      Gan Hong-Seng、Suzuki Tatsuya、Yokosawa Koichi、Ono Yumie
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 8 Issue: 0 Pages: 23-29

    • DOI

      10.14326/abe.8.23

    • NAID

      130007554603

    • ISSN
      2187-5219
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Brain-machine Interface for Stroke Rehabilitation Using Event-related Desynchronization and Proprioceptive Feedback2019

    • Author(s)
      Wada Kenya、Ono Yumie、Kurata Masaya、(Imanishi) Ito Maho、(Tani) Minakuchi Marina、Kono Masashi、Tominaga Takanori
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 8 Issue: 0 Pages: 53-59

    • DOI

      10.14326/abe.8.53

    • NAID

      130007596813

    • ISSN
      2187-5219
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhancement of motor-imagery ability via combined action observation and motor-imagery training with proprioceptive neurofeedback2018

    • Author(s)
      Ono Yumie、Wada Kenya、Kurata Masaya、Seki Naoto
    • Journal Title

      Neuropsychologia

      Volume: 114 Pages: 134-142

    • DOI

      10.1016/j.neuropsychologia.2018.04.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Action observation facilitates motor cortical activity in patients with stroke and hemiplegia2018

    • Author(s)
      Tani Marina、Ono Yumie、Matsubara Miku、Ohmatsu Satoko、Yukawa Yoshihiro、Kohno Masashi、Tominaga Takanori
    • Journal Title

      Neuroscience Research

      Volume: 133 Pages: 7-14

    • DOI

      10.1016/j.neures.2017.10.002

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cross-Brain Neural Mechanism for Human-to-Human Verbal Communication2018

    • Author(s)
      J. Hirsch, J.A. Noah, X. Zhang, S. Dravida, Y. Ono.
    • Journal Title

      Social Cognitive and Affective Neuroscience

      Volume: 13(9) Issue: 9 Pages: 907-920

    • DOI

      10.1093/scan/nsy070

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hand Motor Rehabilitation of Patients with Stroke Using Physiologically Congruent Neurofeedback2018

    • Author(s)
      Ono Yumie、Wada Kenya、Seki Naoto、Imanishi Ito Maho、Tani Minakuchi Marina、Kono Masashi、Tominaga Takanori
    • Journal Title

      2018 IEEE International Conference on Systems, Man, and Cybernetics (SMC)

      Volume: 2018 Pages: 39-44

    • DOI

      10.1109/smc.2018.00016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetoencephalography Reveals Mismatch Field Enhancement from Unexpected Syntactic Category Errors in English Sentences2018

    • Author(s)
      Kubota Mikio、Ono Yumie、Ishiyama Atsushi、Zouridakis George、Papanicolaou Andrew C.
    • Journal Title

      Neuroscience Letters

      Volume: 662 Pages: 195-204

    • DOI

      10.1016/j.neulet.2017.07.051

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of Blood Flow Speed in Shallow and Deep Tissues Using Diffuse Correlation Spectroscopy2017

    • Author(s)
      Mikie Nakabayashi, Yumie Ono
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 6 Issue: 0 Pages: 53-58

    • DOI

      10.14326/abe.6.53

    • NAID

      130006941703

    • ISSN
      2187-5219
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact2017

    • Author(s)
      Hirsch Joy、Zhang Xian、Noah J. Adam、Ono Yumie
    • Journal Title

      NeuroImage

      Volume: 157 Pages: 314-330

    • DOI

      10.1016/j.neuroimage.2017.06.018

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of optimal visual cue for training of motor-imagery response2017

    • Author(s)
      M. Kurata, H. Kayanuma , M. Matsubara, N. Seki, K. Wada, D. Takehara, Y. Ono
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 55Annual Issue: Proc Pages: 562-564

    • DOI

      10.11239/jsmbe.55Annual.562

    • NAID

      130006077271

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of neurofeedback training on event-related desynchronization strength by motor imagery2017

    • Author(s)
      K. Wada, H. Kayanuma , M. Matsubara, N. Seki, M. Kurata, D. Takehara, Y. Ono
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 55Annual Issue: Proc Pages: 565-568

    • DOI

      10.11239/jsmbe.55Annual.565

    • NAID

      130006077280

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an ERD measurement system using Emotiv Epoc2017

    • Author(s)
      D. Takehara, H. Kayanuma , M. Matsubara, N. Seki, K. Wada, M. Kurata, Y. Ono
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 55Annual Issue: Proc Pages: 556-559

    • DOI

      10.11239/jsmbe.55Annual.556

    • NAID

      130006077268

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional Brain Imaging to Assess the Efficacy of Manipulative Therapy for Pain Relief2017

    • Author(s)
      松田康宏, 鈴木達也, 小野塚實, 小野弓絵
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 55 Issue: 1 Pages: 1-8

    • DOI

      10.11239/jsmbe.55.1

    • NAID

      130005612131

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of Music Preferences in Young Adults and Elderly Individuals Using Prefrontal Hemodynamics2017

    • Author(s)
      小野弓絵
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 55 Issue: 1 Pages: 9-16

    • DOI

      10.11239/jsmbe.55.9

    • NAID

      130005612139

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnosis of occlusal dysesthesia utilizing prefrontal hemodynamic activity with slight occlusal interference2016

    • Author(s)
      Y. Ono, Y. Ishikawa, M. Munakata, T. Shibuya, A. Shimada, H. Miyachi, H. Wake, K. Tamaki
    • Journal Title

      Clinical and Experimental Dental Research

      Volume: 2 Issue: 2 Pages: 129-135

    • DOI

      10.1002/cre2.32

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳卒中手指麻痺患者のリハビリテーションを目的とした運動関連脳活動可視化アプリケーションの開発2019

    • Author(s)
      竹原大貴,小野弓絵,小熊宏明,酒井祐也,本間正樹,曽根高則義
    • Organizer
      第21回日本ヒト脳機能マッピング学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Simultaneous EEG and fNIRS co-localization of theta band activity and hemodynamic responses to fusiform gyrus during face perception2018

    • Author(s)
      Swethasri Dravida, Yumie Ono, J. Adam Noah, Xian Zhang and Joy Hirsch
    • Organizer
      SfNIRS2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An fNIRS screening procedure to determine compatibility for neuroimaging2018

    • Author(s)
      J. Adam Noah, Megan Kelley, Swethasri Dravida, Yumie Ono, Xian Zhang and Joy Hirsch
    • Organizer
      SfNIRS2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hand motor rehabilitation of patients with stroke using physiologically congruent neurofeedback2018

    • Author(s)
      Y Ono, K Wada, N Seki, MI Ito, MT Minakuchi, M Kono, T Tominaga
    • Organizer
      IEEE SME 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic Cross-Brain Neural Coupling of Face Processes Reflects the Transfer of Shared Face Information2018

    • Author(s)
      Joy Hirsch, Adam Noah, Xian Zhang, Swetha Dravida, Adam Naples, Yumie Ono, James McPartland
    • Organizer
      SfN2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 慢性期脳卒中片麻痺患者に対するBrain Machine Interface訓練 の効果2018

    • Author(s)
      谷 茉理菜, 富永孝紀, 市村幸盛, 河野正志, 湯川喜裕, 今西麻帆, 藤原瑶平, 関 直人, 和田賢弥, 小野弓絵
    • Organizer
      第43回日本脳卒中学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳波のグレンジャー因果解析による脳ネットワーク活動の可視化2018

    • Author(s)
      Y. Ono, J.A. Noah, X. Zhang, S. Dravida, J. Hirsch
    • Organizer
      電子情報通信学会 2018年総合大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脳卒中片麻痺患者に対するBrain-Machine Interfaceを用いたDigital Mirror Boxの臨床効果2018

    • Author(s)
      河野正志, 谷茉理菜, 今西麻帆, 富永孝紀, 小野弓絵
    • Organizer
      第52回日本作業療法学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 身体機能の可視化技術と医療応用2018

    • Author(s)
      小野弓絵
    • Organizer
      第46回可視化情報シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 慢性期脳卒中後運動麻痺に対するBMIを用いた介入の試み2018

    • Author(s)
      藤原瑶平,柏田夏子,下村亮太,河野正志,市村幸盛,小野弓絵
    • Organizer
      第19回 認知神経リハビリテーション学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 慢性期脳卒中症例に対するBMI訓練の効果2018

    • Author(s)
      藤原瑶平,柏田夏子,下村亮太,河野正志,市村幸盛,小野弓絵
    • Organizer
      第48回臨床神経生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳卒中片麻痺患者に対するBrain-Machine Interfaceを用いたリハビリテーションがF波に及ぼす影響2018

    • Author(s)
      柏田夏子,下村亮太,河野正志,市村幸盛,小野弓絵
    • Organizer
      第16回日本神経理学療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳波のグレンジャー因果解析による脳ネットワーク活動の可視化2018

    • Author(s)
      Y. Ono, J.A. Noah, X. Zhang, S. Dravida, J. Hirsch.
    • Organizer
      電子情報通信学会 2018年総合大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 慢性期脳卒中片麻痺患者に対するBrain Machine Interface訓練の効果2018

    • Author(s)
      谷 茉理菜, 富永孝紀, 市村幸盛, 河野正志, 湯川喜裕, 今西麻帆, 藤原瑶平, 関 直人, 和田賢弥,小野弓絵
    • Organizer
      第43回日本脳卒中学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頭表脳波から手の異なるジェスチャを推定するBCIの検討2017

    • Author(s)
      栢沼 一修, 小野 弓絵
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳卒中片麻痺患者へ複合感覚フィードバックを与えるERD-BMIを適用した4症例2017

    • Author(s)
      松原未来, 栢沼一修, 関直人, 和田賢弥, 倉田雅哉, 小野弓絵, 谷茉理菜, 今西麻帆, 小田恵美香, 藤原瑶平, 富永孝紀
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] SSVEP強度の側方性を指標とした半側空間無視リハビリテーション手法の検討2017

    • Author(s)
      志村真郷, 小野弓絵, 富永孝紀, 谷茉理菜, 今西麻帆
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Effect of single use of BMI rehabilitation system with visuosensory feedback in chronic stroke patients2017

    • Author(s)
      N. Seki, K. Wada, M. Kurata, D. Takehara, M. Imanishi, M. Tani, T. Tominaga, Y. Ono
    • Organizer
      生体医工学シンポジウム2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Digital Mirror Box: An interactive hand-motor BMI rehabilitation for stroke patients2016

    • Author(s)
      Yumie Ono, Takanori Tominaga, Takaho Murata
    • Organizer
      2016 Asia-Pacific Signal and Information Processing Association Annual Summit and Conference (APSIPA ASC 2016)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2016-12-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳卒中片麻痺に対してLF-rTMSとBMIを併用した症例2016

    • Author(s)
      小田恵美香,富永孝紀,谷 茉理菜,柏田夏子,小野弓絵
    • Organizer
      第50回日本作業療法学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Effect of neurofeedback training of steady-state visual evoked potentials on Canonical Correlation Analysis parameter2016

    • Author(s)
      Shohei Morota, Yumie Ono
    • Organizer
      EMBC2016
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2016-08-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Appropriate Timing for Sensory Feedback in ERD-BMI Rehabilitation for Stroke Patients2016

    • Author(s)
      Naoto Seki, Hidenori Kayanuma, Miku Matsubara, Natsuko Kashida, Maho Imanishi, Satoko Omatsu, Marina Tani, Emika Oda, Takaho Murata,Takanori Tominaga, Yumie Ono
    • Organizer
      EMBC2016
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2016-08-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Appropriate timing for sensory feebback in ERD-BMI2016

    • Author(s)
      Naoto Seki, Hidenori Kayanuma, Miku Matsubara, Yumie Ono, Takanori Tominaga, Nathuko Kashida, Maho Imanishi, Satoko Oomathu, Marina Tani, Emika Oda
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] MATLABで学ぶ生体信号処理2018

    • Author(s)
      小野弓絵
    • Total Pages
      174
    • Publisher
      コロナ社
    • ISBN
      9784339072457
    • Related Report
      2018 Annual Research Report
  • [Remarks] 明治大学理工学部電気電子生命学科健康医工学研究室ホームページ

    • URL

      http://www.isc.meiji.ac.jp/~yumie/index.html

    • Related Report
      2018 Annual Research Report 2017 Research-status Report 2016 Research-status Report
  • [Remarks] 明治大学・Youtube『動画でわかる!◯△◇』#1「動画でわかる!医工学」

    • URL

      https://www.youtube.com/watch?v=iSI03nRZ9B8

    • Related Report
      2018 Annual Research Report
  • [Remarks] BMI 技術を用いた半側空間無視リハビリテーションの構築

    • URL

      http://www.tateisi-f.org/html/reports/h27reports/2151006.pdf

    • Related Report
      2017 Research-status Report
  • [Remarks] 理工学部・小野弓絵准教授と穂翔会村田病院が脳卒中リハビリテーション技術を開発

    • URL

      https://www.meiji.ac.jp/koho/press/2015/6t5h7p00000isdvu.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 明治大学『動画でわかる!◯△◇』#1「動画でわかる!医工学」

    • URL

      http://www.meiji.net/study_movie/science_and_technology/vol22_yumie-ono

    • Related Report
      2016 Research-status Report
  • [Remarks] 早稲田大学先進理工学部 卒業生に聞く!

    • URL

      http://www.ase.sci.waseda.ac.jp/graduate/interview012.html

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] リハビリテーション装置及びリハビリテーション方法2016

    • Inventor(s)
      小野弓絵,富永孝紀
    • Industrial Property Rights Holder
      小野弓絵,富永孝紀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-163074
    • Filing Date
      2016-08-23
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 計測装置及び計測方法2016

    • Inventor(s)
      小野弓絵,栢沼一修,富永孝紀,伊藤直義,遠藤豪人
    • Industrial Property Rights Holder
      小野弓絵,栢沼一修,富永孝紀,伊藤直義,遠藤豪人
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-163075
    • Filing Date
      2016-08-23
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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