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Exploring the potential of transcranial static magnetic field stimulation as a new non-invasive brain stimulation tool

Research Project

Project/Area Number 16K01522
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHiroshima University (2017-2018)
Niigata University of Health and Welfare (2016)

Principal Investigator

Kirimoto Hikari  広島大学, 医系科学研究科(保), 教授 (40406260)

Co-Investigator(Kenkyū-buntansha) 大西 秀明  新潟医療福祉大学, リハビリテーション学部, 教授 (90339953)
山代 幸哉  新潟医療福祉大学, 健康科学部, 准教授 (20570782)
浅尾 章彦  新潟医療福祉大学, 医療技術学部, 助教 (40780268)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords静磁場刺激 / 非侵襲的脳刺激 / 感覚 / 視覚 / 経頭蓋静磁場刺激 / 半側空間無視 / 視空間認知 / 痛覚 / 誘発電位 / 静磁場 / 一次体性感覚野 / 体性感覚誘発電位
Outline of Final Research Achievements

Transcranial static magnetic field stimulation (tSMS) is a new type of Non-invasive brain stimulation (NIBS). tSMS reduces cortical excitability using static magnetic fields (SMFs) applied across the scalp with a cylindrical neodymium, iron, and boron (NdFeB) permanent magnet. In this study, we revealed that 1) The amplitudes of intra-epidermal electrical stimulation-evoked potentials (IES-EPs) were decreased immediately and 10-min after the 15-min period of tSMS over M1 2) Transient inhibition of right temporal lobe, induced by 20 min of tSMS, improves the visual spatial cognition, as tested with a line's length judgement task.
Therefore, tSMS can be an alternative or a better tool for modulating cortical nociceptive processing, compared to conventional NIBS techniques with adverse effects, such as itching, tingling, headache, and discomfort.

Academic Significance and Societal Importance of the Research Achievements

私たちの一連の研究により,経頭蓋静磁場刺激は健常被験者の感覚情報処理過程を抑制すること,及び,視空間認知機能を改善することを明らかにした.静磁場刺激は,市販の工業製品であるネオジム磁石(約2-3万円)を頭皮上に載せるのみなので,先行する非侵襲的脳刺激方法を比較してはるかに低コストで,施行に特殊な技術を必要としない.よって,一般の医療機関のみならず在宅リハビリテーションにまで幅広く利用できる可能性を秘めている.
現在は,主に脳卒中後の片麻痺や半側空間無視症状に対する臨床介入研究を進めており,従来型の非侵襲的脳刺激法の代替ツールとなり得るか否かの検証を進めていく.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (34 results)

All 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (16 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 15 results,  Open Access: 12 results,  Acknowledgement Compliant: 9 results) Presentation (12 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] Hospital Nacional de Paraple´jicos(スペイン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Leibniz Research Centre(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Hospital Nacional de Paraplejicos(Spain)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Modulation of Corticospinal Excitability Depends on the Pattern of Mechanical Tactile Stimulation2018

    • Author(s)
      Kojima Sho、Onishi Hideaki、Miyaguchi Shota、Kotan Shinichi、Sasaki Ryoki、Nakagawa Masaki、Kirimoto Hikari、Tamaki Hiroyuki
    • Journal Title

      Neural Plasticity

      Volume: 2018 Pages: 1-9

    • DOI

      10.1155/2018/5383514

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anodal Transcranial Direct Current Stimulation over the Supplementary Motor Area Improves Anticipatory Postural Adjustments In Older Adults2018

    • Author(s)
      Nomura T and Kirimoto H
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Change-Driven M100 Component in the Bilateral Secondary Somatosensory Cortex: A Magnetoencephalographic Study2018

    • Author(s)
      Yamashiro Koya、Sato Daisuke、Onishi Hideaki、Sugawara Kazuhiro、Otsuru Naofumi、Kirimoto Hikari、Nakazawa Sho、Yamazaki Yudai、Shirozu Hiroshi、Maruyama Atsuo
    • Journal Title

      Brain Topography

      Volume: 印刷中 Issue: 3 Pages: 435-444

    • DOI

      10.1007/s10548-018-0687-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing2018

    • Author(s)
      Kirimoto Hikari、Tamaki Hiroyuki、Otsuru Naufumi、Yamashiro Koya、Onishi Hideaki、Nojima Ippei、Oliviero Antonio
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 63-63

    • DOI

      10.3389/fnhum.2018.00063

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Electrical stimulation of denervated rat skeletal muscle ameliorates bone fragility and muscle loss in early-stage disuse musculoskeletal atrophy2017

    • Author(s)
      Tamaki H, Yotani K, Ogita F, Hayao K, Nakagawa K, Sugawara K, Kirimoto H, Onishi H, Kasuga N, Yamamoto N
    • Journal Title

      Calcif Tissue Int

      Volume: 100 Issue: 4 Pages: 420-430

    • DOI

      10.1007/s00223-017-0250-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Decrease in short-latency afferent inhibition during corticomotor postexercise depression following repetitive finger movement2017

    • Author(s)
      Miyaguchi Shota、Kojima Sho、Sasaki Ryoki、Kotan Shinichi、Kirimoto Hikari、Tamaki Hiroyuki、Onishi Hideaki
    • Journal Title

      Brain Behavior

      Volume: 7 Issue: 7

    • DOI

      10.1002/brb3.744

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Excitability Modulation of the Central Nervous System by Transcranial Direct Current Stimulation and Its Clinical Application2017

    • Author(s)
      桐本 光, 大西 秀明
    • Journal Title

      Physical Therapy Japan

      Volume: 44 Issue: 2 Pages: 166-177

    • DOI

      10.15063/rigaku.44-2kikaku_Kirimoto_Hikari

    • NAID

      130006855389

    • ISSN
      0289-3770, 2189-602X
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 経頭蓋静磁場刺激 ―新たなる非侵襲的脳刺激ツール―2017

    • Author(s)
      桐本 光
    • Journal Title

      バイオメカニクス研究

      Volume: 21 Pages: 66-73

    • Related Report
      2017 Research-status Report
  • [Journal Article] Non-invasive modulation of somatosensory evoked potentials by the application of tanscranial static magnetic field stimulation over the primary and supplemental motor cortices2016

    • Author(s)
      Kirimoto H, Asao A, Tamaki H, Onishi H
    • Journal Title

      Scientific Reports

      Volume: - Issue: 1

    • DOI

      10.1038/srep34509

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Difference in cortical relay time between intrinsic muscles of dominant and non-dominant hands2016

    • Author(s)
      Kirimoto H, Tamaki H, Onishi H
    • Journal Title

      Journal of Motor Behavior

      Volume: -

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Transcranial static magnetic field stimulation - new non-invasive brain stimulation tool2016

    • Author(s)
      Kirimoto H, Tamaki H, Onishi H
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 5 Issue: 3 Pages: 205-211

    • DOI

      10.7600/jpfsm.5.205

    • NAID

      130005165310

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex2016

    • Author(s)
      Sasaki R, Miyaguchi S, Kotan S, Kojima S, Kirimoto H, Onishi H
    • Journal Title

      Frontiers in human neuroscience

      Volume: doi Pages: 1-8

    • DOI

      10.3389/fnhum.2016.00030

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Do differences in levels, types, and duration of muscle contraction have an effect on the degree of post-exercise depression?2016

    • Author(s)
      Miyaguchi S, Kojima S, Kirimoto H, Tamaki H, Onishi H
    • Journal Title

      Frontiers in human neuroscience

      Volume: doi Pages: 1-9

    • DOI

      10.3389/fnhum.2016.00159

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of range and angular velocity of passive movement on somatosensory evoked magnetic fields2016

    • Author(s)
      Sugawara K, Onishi H, Yamashiro K, Kojima S, Miyaguchi S, Kotan S, Kirimoto H, Tsubaki A, Tamaki H, Shirozu H, Kameyama S
    • Journal Title

      Brain Topography

      Volume: - Issue: 5 Pages: 693-703

    • DOI

      10.1007/s10548-016-0492-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibitory effect of intensity and inter-stimulus interval of conditioning stimuli on somatosensory evoked magnetic fields2016

    • Author(s)
      Onishi H, Sugawara K, Yamashiro K, Sato D, Kirimoto H, Tamaki H, Shirozu H, Kameyama S
    • Journal Title

      European Journal of Neuroscience

      Volume: - Issue: 4 Pages: 2104-2113

    • DOI

      10.1111/ejn.13317

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of muscle contraction strength on gating of somatosensory magnetic fields2016

    • Author(s)
      Sugawara K, Onishi H, Yamashiro K, Kotan S, Kojima S, Miyaguchi S, Tsubaki A, Kirimoto H, Tamaki H, Shirozu H, Kameyama S
    • Journal Title

      Experimental Brain Research

      Volume: 34(11) Issue: 11 Pages: 3389-3398

    • DOI

      10.1007/s00221-016-4736-z

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Modulation of somatosensory and nociceptive evoked potentials by the application of static magnetic fields2018

    • Author(s)
      Kirimoto H
    • Organizer
      第33回日本生体磁気学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Modulation of cortical somatosensory processing by the application of tSMS2018

    • Author(s)
      Kirimoto H
    • Organizer
      The 1st International Workshop for Static Magnetic Stimulation
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural basis of therapeutic effect of transcranial static magnetic field stimulation2018

    • Author(s)
      Kirimoto H
    • Organizer
      The 12th ICME International Conference on Complex Medical Engineering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 静磁場刺激がタキストスコープによる線分分割課題の精度に及ぼす影響2018

    • Author(s)
      桐本 光,緒方勝也,中薗寿人,鶴 大輔,美馬達哉,飛松省三
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 静磁場刺激によるタキストスコープ線分分割課題の精度の改善2018

    • Author(s)
      桐本 光,鶴 大輔,緒方勝也,中薗寿人,飛松省三,美馬達哉
    • Organizer
      第12回Motor Control研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 側頭葉に対する経頭蓋静磁場刺激によるタキストスコープ線分分割課題の精度の変化2018

    • Author(s)
      桐本 光,緒方勝也,中薗寿人,鶴 大輔,美馬達哉
    • Organizer
      第12回日本作業療法研究学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Transcranial static magnetic field stimulation over the primary motor cortex decreases cortical nociceptive processing2017

    • Author(s)
      H. Kirimoto, H. Tamaki, N. Otsuru, K. Yamashiro, H. Onishi
    • Organizer
      2nd International Brain stimulation Conference
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2017-03-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 一次運動野に対する静磁場刺激による痛覚神経刺激誘発電位の変化2017

    • Author(s)
      桐本光,田巻弘之,大鶴直史,山代幸哉,大西秀明
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 上肢のバリスティックな屈曲運動が足関節の伸筋及び屈筋の興奮性に及ぼす影響2017

    • Author(s)
      桑原貴之,松本卓也,桐本光
    • Organizer
      第51回日本作業療法学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 静磁場刺激が侵害刺激受容過程に及ぼす影響2017

    • Author(s)
      桐本光,田巻弘之,大西秀明
    • Organizer
      第51回日本作業療法学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Non-invasive modulation of cortical somatosensory processing by the application of static magnetic fields2017

    • Author(s)
      Hikari Kirimoto
    • Organizer
      Health Science Mini Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 視標追跡描円課題における両側半球tDCSと従来型片側半球tDCS効果の比較2016

    • Author(s)
      桐本光,浅尾章,小山龍太郎,田巻弘之,大西秀明
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      福島(郡山)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Book] 基礎作業学 第3版2017

    • Author(s)
      編集 濱口豊太,編集協力 桐本光
    • Total Pages
      218
    • Publisher
      医学書院
    • ISBN
      9784260030557
    • Related Report
      2017 Research-status Report
  • [Remarks] 広島ニューロリハ研究会

    • URL

      https://sites.google.com/view/hiroshimaneuroreha

    • Related Report
      2017 Research-status Report
  • [Remarks] 広島大学 研究者総覧

    • URL

      http://seeds.office.hiroshima-u.ac.jp/profile/ja.c388d32d3da43ebc520e17560c007669.html

    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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