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Research for development of multidisciplinary treatment to prevent chronic pain: Examination of combination of psychopharmacology in physical therapy

Research Project

Project/Area Number 16K01525
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionAichi Medical University

Principal Investigator

Ohmichi Yusuke  愛知医科大学, 医学部, 講師 (50506673)

Co-Investigator(Kenkyū-buntansha) 大道 美香  愛知医科大学, 医学部, 助教 (30581079)
安井 正佐也  愛知医科大学, 医学部, 助教 (10723695)
内藤 宗和  愛知医科大学, 医学部, 教授 (10384984)
押淵 英弘  東京女子医科大学, 医学部, 講師 (90568073)
矢倉 富子  愛知医科大学, 医学部, 助教 (20722581)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords慢性痛 / 身体不活動 / 精神薬物療法 / ギプス固定 / 運動療法 / ジクロフェナック / プレガバリン / デュロキセチン / ジクロフェナク / DAMGO / 慢性筋痛 / 不活動 / 不動化 / 運動器 / 骨格筋 / 理学療法
Outline of Final Research Achievements

In this study, we examined the analgesic effects of diclofenac, pregabalin and duloxetine on bilateral mechanical hyperalgesia in the acute and chronic phases in CPCP rats. In the chronic phase, none of the three drugs showed high analgesic effect on the mechanical hyperalgesia. On the other hand, in the acute phase, duloxetine showed a weak analgesic effect on the mechanical hyperalgesia. We hoped for further analgesic effects, and tried continuous administration of duloxetine immediately after casting removal. Contralateral enlargement of the mechanical hyperalgesia was significantly suppressed. The hyperalgesia was able to be reduced bilaterally by continuing the spontaneous exercise using the running wheel before the onset of the chronic phase.

Academic Significance and Societal Importance of the Research Achievements

運動器不活動による慢性筋痛に対し,diclofenac,pregabalinとduloxetinのいずれも高い鎮痛効果は認められなかった.これら3剤中, duloxetineが急性期で弱い鎮痛効果を示したことから,さらなる鎮痛を期待し,ギプス除去直後からの連続投与に試みたところ,対側に拡大する筋痛を有意に抑制することができた.持続的な自発運動はCPCPラットの筋の機械痛覚過敏を抑制した.慢性痛に移行する前のできるだけ早い時期から薬物療法と理学療法の併用を進めることが運動器不活動による痛みの慢性化を防ぐ有効な手段となることが示唆された.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Therapeutic effects of diclofenac, pregabalin, and duloxetine on disuse-induced chronic musculoskeletal pain in rats.2018

    • Author(s)
      Ohmichi Y, Ohmichi M, Murai N, Yasui M, Takeshita N, Oshibuchi H, Naito M, Nakano T, Sato J
    • Journal Title

      Scientific Reports

      Volume: 8 (1) Issue: 1 Pages: 3311-3311

    • DOI

      10.1038/s41598-018-21429-3

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Therapeutic effects of diclofenac, pregabalin, and duloxetine on disuse-induced chronic musculoskeletal pain in rats2019

    • Author(s)
      大道裕介
    • Organizer
      第124回 日本解剖学会総会・全国学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 身体不活動による自発痛関連行動と不快情動関連応答 ―扁桃体基底外側核の活性化と遊離ドパミンの変化―2019

    • Author(s)
      大道美香
    • Organizer
      第124回 日本解剖学会総会・全国学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Therapeutic effects of diclofenac, pregabalin, and duloxetine on disuse-induced chronic musculoskeletal pain in rats2019

    • Author(s)
      Yusuke Ohmichi
    • Organizer
      17th World congress on pain
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ラットにおける後肢不動後の自発痛関連行動と脱毛は酸化ストレスに起因する2018

    • Author(s)
      大道 裕介,大道 美香,安井 正佐也,横田 紘季,内藤 宗和,中野 隆
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラット後肢不動によって生じた 酸化ストレスに起因する広範囲機械痛覚増強2017

    • Author(s)
      大道裕介,大道美香,安井正佐也,内藤宗和,中野隆
    • Organizer
      第122回全国解剖学会総会全国学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-31
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット後肢不動後に生じる 広範囲機械痛覚増強の病態解明-酸化ストレスにより生じた神経原性炎症の関与-2016

    • Author(s)
      大道裕介,安井正佐也,大道美香 内藤宗和,中野隆
    • Organizer
      大道裕介,安井正佐也,大道美香 内藤宗和,中野隆
    • Place of Presentation
      長野
    • Year and Date
      2016-10-16
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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