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Plastic changes in gait cycle by combination of high frequency electrical stimulation to footsole and transcranial direct current stimulation.

Research Project

Project/Area Number 16K01593
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental mechanisms and the body works
Research InstitutionChiba University

Principal Investigator

Komiyama Tomoyoshi  千葉大学, 教育学部, 教授 (70215408)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歩行運動 / 電気刺激 / 経頭蓋的直流電気刺激 / 可塑的変化 / 足底皮膚 / 脊髄 / 高頻度電気刺激 / 足底面 / 直流電気刺激 / 歩行周期 / 高周波電気刺激 / 感覚刺激
Outline of Final Research Achievements

In the present study, we found that high-frequency electrical stimulation (HFS, 1 ms, 300 Hz, 3 pulses, 3x sensory threshold) to the medial anterior part of the plantar skin at a specific walking phase (the latter half of the stance phase) has an effect of prolonging the stance phase. It was also confirmed that this effect was increased by anodal transcranial direct current stimulation (tDCS), and the duration of the effect was also extended by anodal tDCS. In addition, cathodal direct current stimulation to the spinal cord (tsDCS) was effective to involuntarily enhances the cadence of the pedaling movement. These findings suggest that high-frequency electrical stimulation to the footsole affects spinal neural mechanisms that control rhythmic movements during locomotor behaviors, which would receive sustained input from the cerebral cortex.

Academic Significance and Societal Importance of the Research Achievements

本研究では、歩行運動中に足底部皮膚に対する低強度の高頻度電気刺激によって歩行周期を可塑的変化させることが可能であり、加えてこの効果は大脳皮質に対する非侵襲的な直流電気刺激によって促進もしくは減弱させることが可能であることが明らかになった。また、脊髄に対する陰極直流電気刺激によってペダリング回転数が不随意的に増大することも明らかになった。これらの知見は、歩行運動やペダリング運動のような律動運動の活動周期を非侵襲的な電気刺激によって可塑的に変化させることが可能であること、ならびに本研究結果の応用によって、歩行障害等に対するリハビリテーション・トレーニングの効果を高める可能性も考えられた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results) Presentation (10 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] University of Victoria(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 歩行のヒト脊髄神経機構:皮膚感覚による反射制御とその機能2019

    • Author(s)
      中島剛、小宮山伴与志
    • Journal Title

      日本運動生理学雑誌

      Volume: 26 Pages: 19-26

    • NAID

      40021853792

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polarity-dependent improvement of maximal-effort sprint cycling performance by direct current stimulation of the central nervous system2017

    • Author(s)
      SyusakuSasada, TakashiEndoh, Tomoya Ishii, TomoyoshiKomiyamd
    • Journal Title

      Neuroscience Letters

      Volume: 657(14) Pages: 97-101

    • DOI

      10.1016/j.neulet.2017.07.056

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural mechanisms underlying reversal of cutaneous reflexes during human bipedal walking2016

    • Author(s)
      Tsuyoshi Nakajima, Shinya Suzuki, Genki Futatsubashi, Hiroyuki Ohtsuska2,4, Rinaldo A. Mezzarane, Trevor S. Barss, Taryn Klarner, E. Paul Zehr and Tomoyoshi Komiyama
    • Journal Title

      Journal of Neurophysiology

      Volume: In press Issue: 1 Pages: 1-25

    • DOI

      10.1152/jn.01011.2015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Soleus Hoffmann reflex amplitudes are specifically modulated by cutaneous inputs from the arms and opposite leg during walking but not standing.2016

    • Author(s)
      S. Suzuki, T. Nakajima, G. Futatsubashi, R.A. Mezzarane, H. Ohtsuka, Y. Ohki, E.P. Zehr, and T. Komiyama
    • Journal Title

      Experimental Brain Research

      Volume: 未定 Issue: 8 Pages: 2293-2304

    • DOI

      10.1007/s00221-016-4635-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A common neural element receiving rhythmic arm and leg activity as assessed by reflex modulation in arm muscles.2016

    • Author(s)
      Sasada S, Tazoe T, Nakajima T, Futatsubashi G, Ohtsuka H, Suzuki S, Zehr EP, Komiyama T.
    • Journal Title

      Journal of Neurophysiology

      Volume: 115(4) Issue: 4 Pages: 2065-2075

    • DOI

      10.1152/jn.00638.2015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 脊髄直流電気刺激による不随意なサイクリングケイデンスの上昇2018

    • Author(s)
      笹田周作、石井 智也、遠藤隆志、小宮山伴与志
    • Organizer
      第26回日本運動生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脊髄直流電流刺激によるサイクリング位相依存的な皮膚反射の修飾2018

    • Author(s)
      笹田周作、石井智也、遠藤隆志、中島剛、小宮山伴与志
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Involuntary changes in leg cycling cadence following transcutaneous spinal direct current stimulation2018

    • Author(s)
      S. SASADA, T. YAMAGUCHI, T. ISHII, T. NAKAJIMA, T. ENDOH, T. KOMIYAMA
    • Organizer
      Society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visual stimulation facilitates cervical interneuron systems mediating corticospinal excitation to motoneurons in arm muscles.2018

    • Author(s)
      Nakajima T, Ohtsuka H, Irie S, Ariyasu R, Suzuki S, Komiyama T, Ohki Y
    • Organizer
      Society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhancement of intermuscular electromyogram coherences in human upper limb during natural manipulation task2018

    • Author(s)
      Ohtsuka H, Suzuki S, Irie S, Ariyasu R, Komiyama T, Nakajima T
    • Organizer
      Society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 一次運動野に対する経頭蓋的直流電流刺激が随意筋収縮後の神経筋機能に及ぼす影響2017

    • Author(s)
      石井智也
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 運動時間に依存した経頭蓋直流電流刺激による サイクリングパフォーマンスの向上2017

    • Author(s)
      笹田周作
    • Organizer
      日本スポーツ健康科学学会 第5回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒト頸髄介在ニューロン系への前庭入力の収束2017

    • Author(s)
      鈴木 伸弥
    • Organizer
      第52回日本理学療法学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Improvement of sprint cycling performance by trans-spinal direct current stimulation2016

    • Author(s)
      S. SASADA, T. ENDOH, T. ISHII, T. KOMIYAMA
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report
  • [Presentation] Change in the cutaneous reflexes during walking in patient with chronic ankle instability2016

    • Author(s)
      G. FUTATSUBASHI, S. SUZUKI, H. OHTSUKA, T. KOMIYAMA
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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