• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of muscle oxygen dynamics in deep tissue using transmitted NIR light

Research Project

Project/Area Number 16K01735
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionTokyo Medical University

Principal Investigator

Kime Ryotaro  東京医科大学, 医学部, 講師 (90366120)

Co-Investigator(Kenkyū-buntansha) 庭山 雅嗣  静岡大学, 電子工学研究所, 准教授 (40334958)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords近赤外線分光法 / 筋組織酸素動態 / 平均光路長 / 自転車運動 / 近赤外線時間分解分光法 / 筋酸素動態 / 皮下脂肪厚 / 散乱光 / 透過光 / 運動性充血 / 皮膚血流量 / エネルギー代謝 / 骨格筋代謝
Outline of Final Research Achievements

We tried to monitor to detect muscle deoxygenation in deep tissue by developed multi-detectros NIRS probe using transmitted light, not scatter light. Since deep muscle tissue has high hemoglobin and myoglobin, the detected light power has been insufficient by usual method. therefore, we tried to pinch measurement site, especially subcutaneous adipose tissue, to minimize the effects of scattering of adipose tissue. Finally, we can detect Soleus muscle deoxygenation using transmitted NIR light at rest during isometric exercise.

Academic Significance and Societal Importance of the Research Achievements

近赤外線分光法(NIRS)を用いた運動時の筋組織計測は、その計測方法が簡便なことからスポーツ医科学の分野でも広く利用されているが、散乱光を利用しているため皮下1~2センチ程度の筋組織しか計測していない。筋組織の深層部は遅筋線維が多いため、運動時には主働筋として動員されているが、それらの情報をNIRSでは検出できないのが現状である。そこで、受光センサーを複数設置して受光量を増やすプローブを開発し、散乱光ではなく透過光を用いて運動時における筋組織酸素動態の計測を試みた。その結果、透過光を用いて安静時および等尺性運動時におけるヒラメ筋の酸素動態を検出することに成功した。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2020 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (10 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results)

  • [Journal Article] Limited muscle oxygen diffusive transport during exercise in humans2020

    • Author(s)
      Kime, R., T. Endo, R. Tanaka, S. Fuse, M. Kuroiwa, Y. Kurosawa, T. Hamaoka.
    • Journal Title

      Proc. SPIE

      Volume: 11237 Pages: 1-9

    • DOI

      10.1117/12.2550671

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Reduced optical path length in the vastus lateralis during ramp cycling exercise2020

    • Author(s)
      Endo,T., R. Kime, T. Watanabe, N. Murase, S. Fuse, R. Tanaka, M. Kuroiwa, Y. Kurosawa and T. Hamaoka
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 1232 Pages: 239-244

    • DOI

      10.1007/978-3-030-34461-0_30

    • ISBN
      9783030344597, 9783030344610
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced scattering coefficient during incremental exercise is constant without being affected by changes in muscle oxygenation or hemodynamics2020

    • Author(s)
      Endo,T., R Kime, S Fuse, N Murase, Y Kurosawa, T Hamaoka
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of exercise training on cardiac and skeletal muscle function2020

    • Author(s)
      Watanabe, T., N. Murase, R. Kime, Y. Kurosawa, S.Fuse, and T. Hamaoka
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced optical path length in the vastus lateralis during ramp cycling exercise2019

    • Author(s)
      Endo T, Kime R, Watanabe T, Fuse S, Murase N, Kurosawa Y, Hamaoka T
    • Journal Title

      Advances in Experimental Medicine & Biology

      Volume: 印刷中 Pages: 97-101

    • DOI

      10.1007/978-3-319-91287-5_16

    • ISBN
      9783319912851, 9783319912875
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Functional Hyperemia Using NIRTRS without the Influence of Fat Layer Thickness2018

    • Author(s)
      Tasuki Endo, Ryotaro Kime, Sayuri Fuse, Tsubasa Watanabe, Norio Murase Yuko Kurosawa and Takafumi Hamaoka
    • Journal Title

      Advanced Experimental Biology and Medicine

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Optical property dynamics during exercise measured by near-infrared time-resolved spectroscopy in humans2020

    • Author(s)
      Endo,T., R Kime, S Fuse, N Murase, Y Kurosawa, T Hamaoka
    • Organizer
      SPIE BiOS 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exercise-induced blood volume expansion measured by NIRS is derived from muscle tissue, not from skin2019

    • Author(s)
      Kime,R., T Endo, S Fuse, T Watanabe, M Niwayama, M Kuroiwa, R Tanaka, Y Kurosawa and T Hamaoka
    • Organizer
      The 47th meeting of International Society of Oxygen Transport to Tissue (ISOTT)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NIRSを用いた運動誘発性血管拡張の評価に及ぼす皮膚血流の影響2018

    • Author(s)
      木目良太郎,遠藤祐輝,渡辺 翼, 布施沙由理,田中璃己,黒澤裕子,浜岡隆文
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 活動筋の平均光路長は漸増負荷自転車運動中に短縮する2018

    • Author(s)
      遠藤祐輝,木目良太郎, 布施沙由理,渡辺 翼,村瀬訓生,黒澤裕子,浜岡隆文
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 持久性鍛錬者と非鍛錬者における運動中の筋組織血液・酸素動態の差異 - NIRTRSを用いて -2018

    • Author(s)
      遠藤祐輝,木目良太郎, 布施沙由理,渡辺 翼,村瀬訓生,黒澤裕子,浜岡隆文
    • Organizer
      第22回酸素ダイナミクス研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Reduced optical path length during ramp cycling exercise2018

    • Author(s)
      Endo T, Kime R, Fuse S, Watanabe T, Murase N, Kurosawa Y, Hamaoka T
    • Organizer
      The 46th annual meeting of the International Society on Oxygen Transport to Tissue ( ISOTT)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of deep muscle oximeter for deformed tissues by pinching using near-infrared spectroscopy2018

    • Author(s)
      Matsuki Y and Niwayama M
    • Organizer
      The 3rd International Symposium on Biomedical Engineering
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evidence that exercise-induced blood volume expansion is derived from muscle tissue, not from skin2017

    • Author(s)
      Ryotaro Kime, Tasuki Endo, Sayuri Fuse, Tsubasa Watanabe, Masatsugu Niwayama, Yuko Kurosawa and Takafumi Hamaoka
    • Organizer
      The 45th Annual meeting of the International Society on Oxygen Transport to Tissue
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Functional Hyperemia Using NIRTRS without the Influence of Fat Layer Thickness2017

    • Author(s)
      Tasuki Endo, Ryotaro Kime, Sayuri Fuse, Tsubasa Watanabe, Norio Murase Yuko Kurosawa and Takafumi Hamaoka
    • Organizer
      The 45th Annual meeting of the International Society on Oxygen Transport to Tissue
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 近赤外分光法を用いた筋機能の評価2017

    • Author(s)
      木目 良太郎
    • Organizer
      「第 34 回筋肉の会」・「第 2 回身体運動制御の会」 ジョイントミーティング
    • Related Report
      2017 Research-status Report
    • Invited

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi