Effect of anaerobic exercise under hypoxia on secretions of angiogenic regulators

• Project/Area Number: 16K01744
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Chukyo University
• Principal Investigator: Kon Michihiro 中京大学, 国際教養学部, 教授 (00455445)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 低酸素 / 運動 / トレーニング / 血管新生因子 / ホルモン / 高強度インターバル運動 / 低強度 / レジスタンス運動 / 無酸素性運動

Outline of Final Research Achievements

Previous study reported that anaerobic training (resistance training) under hypoxia might stimulate angiogenesis compared with that under normoxia. However, the underlining mechanisms of the training-induced angiogenesis have not been clarified. Therefore, we investigated the effects of acute anaerobic exercise under hypoxia on angiogenic regulators. Our study suggests that acute anaerobic exercise in hypoxic condition stimulates vascular endothelial growth factor (VEGF) secretion than that in normoxic condition.

Academic Significance and Societal Importance of the Research Achievements

低酸素環境下で行う無酸素性トレーニングが，常酸素環境下以上に血管新生を促進させるメカニズムの一つであることが明らかとなった．運動トレーニングによる血管新生（毛細血管数の増加）は，筋持久力やエネルギー代謝の向上をもたらす要因の一つである．従って，低酸素環境下で行う無酸素性トレーニング（レジスタンストレーニング，高強度インターバルトレーニング）は，常酸素環境下で行う無酸素性トレーニングよりも，健康増進や競技力向上に役立つ可能性があると思われる．

Research Products

• [Journal Article] Effects of a single bout of high-intensity interval exercise on C1q/TNF-related proteins (2019)
  • Author(s): Kon M, Ebi Y, Nakagaki K
  • Journal Title: Applied Physiology, Nutrition, and Metabolism Volume: 44 Issue: 1 Pages: 47-51
  • DOI: 10.1139/apnm-2018-0355
  • Peer Reviewed
• [Journal Article] Responses of angiogenic regulators to resistance exercise under systemic hypoxia (2018)
  • Author(s): Kon M, Ikeda T, Homma T, Suzuki Y
  • Journal Title: J Strength Cond Res Volume: 33 Issue: 2 Pages: 436-441
  • DOI: 10.1519/jsc.0000000000002695
  • Peer Reviewed
• [Presentation] 低酸素トレーニングと筋肉・筋パワー (2018)
  • Author(s): 今 有礼
  • Organizer: 第21回高所トレーニング国際シンポジウム2018
  • Int'l Joint Research / Invited
• [Presentation] 低酸素環境で行う無酸素生運動・トレーニングの効果 (2018)
  • Author(s): 今 有礼
  • Organizer: 第69回日本体育学会
  • Invited
• [Presentation] 低酸素環境下での無酸素性運動・トレーニングによる生理的応答 (2016)
  • Author(s): 今 有礼
  • Organizer: 第27回日本臨床スポーツ医学会学術集会
  • Place of Presentation: 千葉県千葉市
  • Year and Date: 2016-11-06
  • Invited