| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The purpose of this study was to clarify whether chronic exercise after the spatial memory acquisition by aversive stimulation causes extinction of the spatial memory and changes of protein expression of peroxisome proliferator-activated receptorγcoactivator-1α（PGC-1α） and 5´adenosine monophosphate-activated protein kinaseα（AMPKα） using rats with low spatial learning ability. The rats with low spatial learning ability have been low PGC-1α and AMPKα expression. In rats with low spatial learning ability, the retention of the spatial memory by Morris water maze has been reduced by chronic running exercise, and PGC-1α and AMPKα in dorsal hippocampus has increased. It is suggested that AMPK signaling may plays an important role in memory extinction by chronic exercise in rats with low spatial learning ability, though the further investigation of the relationship between memory extinction and AMPK signaling is needed.
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