changing role of vagal nerve by aging and obesity
Project/Area Number |
16K01815
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
|
Research Institution | Kanazawa University |
Principal Investigator |
Kimura Kumi 金沢大学, 医学系, 助教 (60409472)
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 自律神経 / インスリン抵抗性 / 糖代謝 / 肝糖代謝 / 迷走神経 / 中枢インスリン作用 / 糖尿病 / 肥満 / エネルギー代謝 |
Outline of Final Research Achievements |
In this study, we used DMV-hM3Dq / DMV-hM4Di mice and examined effects of aging and obesity on changing role of vagal nerve. In DMV-hM3Dq mice, CNO administration activated vagus nerve activity and induced insulin secretion, immediately. In DMV-hM4Di mice, CNO administration suppressed vagus nerve activity and inhibited insulin secretion, transiently. However, these mice (both DMV-hM3Dq and DMV-hM4Di) exhibited elevation of blood glucose levels by treatment with ligand. These data suggested a need for analysis of other hormones except for insulin.
|
Academic Significance and Societal Importance of the Research Achievements |
自律神経を介した肝臓代謝調節の加齢・肥満による変化を解明することは、加齢・肥満における生活習慣病の病態理解を深め、多様な疾患が合併する生活習慣病の新たな予防法の開発を可能にすると考えている。
|
Report
(4 results)
Research Products
(1 results)
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[Journal Article] Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor.2016
Author(s)
Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
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Journal Title
Cell reports
Volume: 14
Issue: 10
Pages: 2362-2374
DOI
Related Report
Peer Reviewed / Open Access