| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we used DMV-hM3Dq / DMV-hM4Di mice and examined effects of aging and obesity on changing role of vagal nerve. In DMV-hM3Dq mice, CNO administration activated vagus nerve activity and induced insulin secretion, immediately. In DMV-hM4Di mice, CNO administration suppressed vagus nerve activity and inhibited insulin secretion, transiently. However, these mice (both DMV-hM3Dq and DMV-hM4Di) exhibited elevation of blood glucose levels by treatment with ligand. These data suggested a need for analysis of other hormones except for insulin.
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