The regulatory mechanisms of inflammation by exercise via lipid mediators

• Project/Area Number: 16K01819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kobe University
• Principal Investigator: Kobayashi Seimi 神戸大学, 医学部附属病院, 特命講師 (20379415)
• Co-Investigator(Kenkyū-buntansha): 井澤 和大 神戸大学, 保健学研究科, 准教授 (10736185) ; 篠原 正和 神戸大学, 医学研究科, 准教授 (80437483)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 心臓リハビリテーション / 脂質メディエーター / 運動療法 / 抗炎症効果 / 有酸素運動 / 心血管疾患 / 炎症 / リハビリテーション / 循環器・高血圧 / 分析科学 / 生体分子 / 脂質

Outline of Final Research Achievements

Anti-inflammatory action is expected as one of the effects of exercise therapy on cardiovascular diseases, but the mechanisms are unclear. We aimed to examine the mechanisms of anti-inflammatory roles of exercise therapy associated with lipid mediators. The 20-min exercise using cycle ergometer with the intensity around anaerobic threshold (AT) revealed to reduce the ratio of pro-inflammatory lipid mediators (PG group) /anti-inflammatory lipid mediators (Resolvin group) in the plasma of healthy adult volunteer. The vigorous exercise with the intensity of over 140%AT increased the ratio conversely. The results coincide with the idea that the exercise with the intensity of AT is safe and effective for the patients with cardiovascular diseases, and should be encouraged to continue.

Academic Significance and Societal Importance of the Research Achievements

心臓リハビリテーションは心血管疾患の長期予後を改善する治療法の一つとして様々なガイドライン上でクラスIとして推奨されており、実臨床で広くその有効性が認められているが、その方法論については経験によるものが多く科学的根拠が少ない。本研究では、特に炎症と脂質メディエーターに焦点をあてて行った。従来から安全でかつ効果が高いと考えられてきた、嫌気性閾値レベルの強度の有酸素運動が抗炎症効果を持つ可能性が示唆された。運動療法の新たなエビデンスとするため、今後もさらに研究を継続する予定である。

Research Products

• [Journal Article] Effects of postoperative dietary intake on functional recovery of patients undergoing cardiac surgery. (2019)
  • Author(s): Ogawa M, Izawa KP, Satomi-Kobayashi S, Tsuboi Y, Komaki K, Gotake Y, Yoshida N, Wakida K, Uchida J, Sakai Y, Okita Y.
  • Journal Title: Nutr Metab Cardiovasc Dis. Volume: 29 Issue: 1 Pages: 90-96
  • DOI: 10.1016/j.numecd.2018.10.004
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of preoperative amino acid supplements on postoperative physical function and complications in open heart surgery patients: A study protocol for a randomized controlled trial. (2019)
  • Author(s): Ogawa M, Yoshida N, Satomi-Kobayashi S, Tsuboi Y, Komaki K, Wakida K, Gotake Y, Inoue T, Tanaka H, Yamashita T, Sakai Y, Izawa KP, Takahashi M, Ogawa W, Hirata KI.
  • Journal Title: J Cardiol. Volume: 印刷中 Issue: 4 Pages: 360-365
  • DOI: 10.1016/j.jjcc.2019.03.011
  • Peer Reviewed / Open Access
• [Journal Article] Modulation of High-Density Lipoprotein Function via Cardiac Rehabilitation (2018)
  • Author(s): Satomi-Kobayashi S, Ishida T.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 2 Pages: 128-130
  • DOI: 10.5551/jat.ED089
  • NAID: 130006328448
  • ISSN: 1340-3478, 1880-3873
• [Journal Article] Associations of Exercise Tolerance With Hemodynamic Parameters for Pulmonary Arterial Hypertension and for Chronic Thromboembolic Pulmonary Hypertension (2017)
  • Author(s): Tsuboi Yasunori、Tanaka Hidekazu、Nishio Ryo、Sawa Takuma、Terashita Daisuke、Nakayama Kazuhiko、Satomi-Kobayashi Seimi、Sakai Yoshitada、Emoto Noriaki、Hirata Ken-ichi
  • Journal Title: Journal of Cardiopulmonary Rehabilitation and Prevention Volume: 37 Issue: 5 Pages: 341-346
  • DOI: 10.1097/hcr.0000000000000257
  • Peer Reviewed
• [Journal Article] Impact of delirium on postoperative frailty and long term cardiovascular events after cardiac surgery (2017)
  • Author(s): Ogawa Masato、Izawa Kazuhiro P.、Satomi-Kobayashi Seimi、Tsuboi Yasunori、Komaki Kodai、Gotake Yasuko、Sakai Yoshitada、Tanaka Hiroshi、Okita Yutaka
  • Journal Title: PLOS ONE Volume: 12 Issue: 12 Pages: 0359-0359
  • DOI: 10.1371/journal.pone.0190359
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative exercise capacity is associated with the prevalence of postoperative delirium in elective cardiac surgery (2017)
  • Author(s): Ogawa Masato、Izawa Kazuhiro P.、Satomi-Kobayashi Seimi、Kitamura Aki、Tsuboi Yasunori、Komaki Kodai、Ono Rei、Sakai Yoshitada、Tanaka Hiroshi、Okita Yutaka
  • Journal Title: Aging Clinical and Experimental Research Volume: 30 Issue: 1 Pages: 27-34
  • DOI: 10.1007/s40520-017-0736-5
  • Peer Reviewed