| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We aimed to find an index for comprehensive estimation of the articular cartilage. We quantitated the glycosaminoglycan（GAG）and collagen（COL）as main extracellular matrix constituents of the articular cartilage at various growing stages during maturation in male rats. For COL quantitation, we measured hydroxyproline（Hyp）, an unique modified amino acid in COL protein.
The amount of GAG was decreasing dramatically during the early maturation and then mildly at the latter half of maturation. On the other hand, the amount of Hyp was increasing constantly. The GAG/Hyp ratio is also dramatically changed during maturation and the ratio showed a unique value for each maturation stage clearly. Therefore, it is possible that the GAG/Hyp ratio may be a useful index for the estimation of the articular cartilage during maturation.
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