| Project/Area Number |
16K01823
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 異所性脂肪 / 糖尿病 / 心臓血管病 / サルコペニア / インスリン抵抗性 / 生活習慣病 |
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| Outline of Final Research Achievements |
The purpose of this study is: First, to investigate the clinical significance of cardiac fat, ectopic fat, and sarcopenia, the pathological significance of lifestyle-related diseases, and the onset and progression of cardiovascular diseases; Second, to verify the physiologically active substances derived from the ectopic fat and to elucidate the molecular mechanisms involved in the pathophysiology of of ectopic fat in lifestyle-related diseases and cardiovascular diseases; Third, to buidl a new concept considering cardiac fat, ectopic fat, and sarcopenia.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、第一に心臓脂肪・異所性脂肪・サルコペニアの存在様式が生活習慣病・心臓血管病の発症・進展におよぼす病的意義を解明する、第二に心臓脂肪・異所性脂肪由来の生理活性物質を網羅的に検証し、生活習慣病・心臓血管病の病態に関わるメカニズムを解明する、第三に心臓脂肪・異所性脂肪・サルコペニアを考慮した新しい診療コンセプトを構築する、ことを目的とした。“心臓脂肪・異所性脂肪・サルコペニアの生活習慣病、心臓血管病の発症における病的意義の解明”という課題の解決に関わる成果をあげ、学術的、社会的意義を有する。
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