Elucidation of concept of ectopic fat consortium of cardiac fat, ectopic fat and sarcopenia and life-style diseases

• Project/Area Number: 16K01823
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Fukushima Medical University
• Principal Investigator: Shimabukuro Michio 福島県立医科大学, 医学部, 教授 (60271144)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 異所性脂肪 / 糖尿病 / 心臓血管病 / サルコペニア / インスリン抵抗性 / 生活習慣病

Outline of Final Research Achievements

The purpose of this study is: First, to investigate the clinical significance of cardiac fat, ectopic fat, and sarcopenia, the pathological significance of lifestyle-related diseases, and the onset and progression of cardiovascular diseases; Second, to verify the physiologically active substances derived from the ectopic fat and to elucidate the molecular mechanisms involved in the pathophysiology of of ectopic fat in lifestyle-related diseases and cardiovascular diseases; Third, to buidl a new concept considering cardiac fat, ectopic fat, and sarcopenia.

Academic Significance and Societal Importance of the Research Achievements

本研究では、第一に心臓脂肪・異所性脂肪・サルコペニアの存在様式が生活習慣病・心臓血管病の発症・進展におよぼす病的意義を解明する、第二に心臓脂肪・異所性脂肪由来の生理活性物質を網羅的に検証し、生活習慣病・心臓血管病の病態に関わるメカニズムを解明する、第三に心臓脂肪・異所性脂肪・サルコペニアを考慮した新しい診療コンセプトを構築する、ことを目的とした。“心臓脂肪・異所性脂肪・サルコペニアの生活習慣病、心臓血管病の発症における病的意義の解明”という課題の解決に関わる成果をあげ、学術的、社会的意義を有する。

Research Products

• [Journal Article] Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction (2020)
  • Author(s): Maimaituxun Gulinu、Yamada Hirotsugu、Fukuda Daiju、Yagi Shusuke、Kusunose Kenya、Hirata Yukina、Nishio Susumu、Soeki Takeshi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio
  • Journal Title: Circulation Journal Volume: 84 Issue: 2 Pages: 203-216
  • DOI: 10.1253/circj.CJ-19-0793
  • NAID: 130007789877
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-01-24
  • Peer Reviewed / Open Access
• [Journal Article] Levels of Adiponectin Expression in Peri-Renal and Subcutaneous Adipose Tissue and Its Determinants in Human Biopsied Samples (2020)
  • Author(s): Maimaituxun Gulinu、Fukuda Daiju、Izaki Hirofumi、Hirata Yoichiro、Kanayama Hiro-omi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio
  • Journal Title: Frontiers in Endocrinology Volume: 10 Pages: 897-897
  • DOI: 10.3389/fendo.2019.00897
  • NAID: 120006953545
  • Peer Reviewed / Open Access
• [Journal Article] New risk prediction model of coronary heart disease in participants with and without diabetes: Assessments of the Framingham risk and Suita scores in 3-year longitudinal database in a Japanese population (2019)
  • Author(s): Hirai Hiroyuki、Asahi Koichi、Yamaguchi Satoshi、Mori Hirotaka、Satoh Hiroaki、Iseki Kunitoshi、Moriyama Toshiki、Yamagata Kunihiro、Tsuruya Kazuhiko、Fujimoto Shouichi、Narita Ichiei、Konta Tsuneo、Kondo Masahide、Shibagaki Yugo、Kasahara Masato、Watanabe Tsuyoshi、Shimabukuro Michio
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 2813-2813
  • DOI: 10.1038/s41598-019-39049-w
  • Peer Reviewed / Open Access
• [Journal Article] Effect of the Epicardial Adipose Tissue Volume on the Prevalence of Paroxysmal and Persistent Atrial Fibrillation (2018)
  • Author(s): Oba Kageyuki、Maeda Minetaka、Maimaituxun Gulinu、Yamaguchi Satoshi、Arasaki Osamu、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Nishio Susumu、Iwase Takashi、Takao Shoichiro、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio
  • Journal Title: Circulation Journal Volume: 82 Issue: 7 Pages: 1778-1787
  • DOI: 10.1253/circj.CJ-18-0021
  • NAID: 130007410632
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-06-25
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of Epicardial Adipose Tissue Volume to Predict Recurrent Atrial Fibrillation After Radiofrequency Catheter Ablation (2018)
  • Author(s): Maeda Minetaka、Oba Kageyuki、Yamaguchi Satoshi、Arasaki Osamu、Sata Masataka、Masuzaki Hiroaki、Shimabukuro Michio
  • Journal Title: The American Journal of Cardiology Volume: 122 Issue: 10 Pages: 1694-1700
  • DOI: 10.1016/j.amjcard.2018.08.005
  • Peer Reviewed / Open Access
• [Journal Article] Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease ― New Prediction Model in Combination With Framingham Risk Score ― (2018)
  • Author(s): Maimaituxun Gulinu、Shimabukuro Michio、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Iwase Takashi、Takao Shoichiro、Matsuura Tomomi、Ise Takayuki、Kusunose Kenya、Tobiume Takeshi、Yamaguchi Koji、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Issue: 5 Pages: 1369-1378
  • DOI: 10.1253/circj.CJ-17-1289
  • NAID: 130006725981
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Plasma brain natriuretic peptide levels are elevated in patients with cancer. (2017)
  • Author(s): Bando S, Soeki T, Matsuura T, Tobiume T, Ise T, Kusunose K, Yamaguchi K, Yagi S, Fukuda D, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Muguruma N, Takayama T, Kishimoto I, Kangawa K, Sata M.
  • Journal Title: PLoSOne Volume: 12 Issue: 6 Pages: e0178607-e0178607
  • DOI: 10.1371/journal.pone.0178607
  • NAID: 120006534961
  • Peer Reviewed / Open Access
• [Journal Article] Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery. (2017)
  • Author(s): Maimaituxun G, Shimabukuro M, Salim HM, Tabata M, Yuji D, Morimoto Y, Akasaka T, Matsuura T, Yagi S, Fukuda D, Yamada H, Soeki T, Sugimoto T, Tanaka M, Takanashi S, Sata M.
  • Journal Title: PLoSOne Volume: 12 Issue: 6 Pages: e0177170-e0177170
  • DOI: 10.1371/journal.pone.0177170
  • NAID: 120006534964
  • Peer Reviewed / Open Access
• [Journal Article] Echocardiographic Epicardial Adipose Tissue Thickness Is Associated with Symptomatic Coronary Vasospasm during Provocative Testing. (2017)
  • Author(s): Nishio S, Kusunose K, Yamada H, Hirata Y, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
  • Journal Title: J Am Soc Echocardiogr Volume: 30 Issue: 10 Pages: 1021-1027
  • DOI: 10.1016/j.echo.2017.06.024
  • Peer Reviewed / Open Access
• [Journal Article] Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice. (2017)
  • Author(s): Hotimah Masdan Salim, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro, Masataka Sata.
  • Journal Title: Vascular Pharmacology Volume: 印刷中 Pages: 19-25
  • DOI: 10.1016/j.vph.2017.03.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study (2017)
  • Author(s): Shimabukuro M, Tanaka A, Sata M, Dai K, Shibata Y, Inoue Y, Ikenaga H, Kishimoto S, Ogasawara K, Takashima A, Niki T, Arasaki O, Oshiro K, Mori Y, Ishihara M, Node K
  • Journal Title: Cardiovascular Diabetology Volume: 16 Issue: 1 Pages: 86-86
  • DOI: 10.1186/s12933-017-0571-1
  • NAID: 120006937640
  • Peer Reviewed / Open Access
• [Journal Article] Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue (2016)
  • Author(s): Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Murata C, Kim-Kaneyama JR, Sato F, Bando M, Yagi S, Soeki T, Hayashi T, Imoto I, Sakaue H, Shimabukuro M, Sata M.
  • Journal Title: Sci Adv. Volume: 2(3) Issue: 3
  • DOI: 10.1126/sciadv.1501332
  • Peer Reviewed / Open Access
• [Journal Article] Glycemic control with ipragliflozin, a novel selective SGLT2 inhibitor, ameliorated endothelial dysfunction in streptozotocin-induced diabetic mouse (2016)
  • Author(s): Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M
  • Journal Title: Front Cardiovasc Med Volume: 3 Pages: 43-43
  • DOI: 10.3389/fcvm.2016.00043
  • NAID: 120006937668
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe. (2016)
  • Author(s): Shimabukuro M, Okawa C, Yamada H, Yanagi S, Uematsu E, Sugasawa N, Kurobe H, Hirata Y, Kim-Kaneyama JR, Lei XF, Takao S, Tanaka Y, Fukuda D, Yagi S, Soeki T, Kitagawa T, Masuzaki H, Sato M, Sata M.
  • Journal Title: J Nutr Biochem. Volume: 35 Pages: 66-73
  • DOI: 10.1016/j.jnutbio.2016.05.010
  • Peer Reviewed / Open Access / Int'l Joint Research