| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We previously reported that H2 gas inhalation improved brain and cardiac function in a rat model of cardiac arrest. In this study, we examined the genes expression of post-cardiac arrest treated with H2 using a DNA microarray based comprehensive approach.
We investigated which differentially expressed gene on gene ontology (GO) terms and biological pathways were highly related to the effect of H2 gas inhalation. List of differentially expressed gene were analyzed based on their enrichment scores for associated GO terms and KEGG pathways. As a result, we found several metabolic pathways and differentially Expressed Gene by effect of H2 gas inhalation. It is suggested that these genes may contribute to the H2 inhalation on brain and cardiac function after post-cardiac arrest syndrome.
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