Investigation of cerebral hemodynamic alteration following dynamic aerobic exercise: an applied research project for analysis of regional cerebral blood flow using positron emission tomography

• Project/Area Number: 16K01841
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Aomori University (2018-2019); Hosei University (2016-2017)
• Principal Investigator: Hiura Mikio 青森大学, 脳と健康科学研究センター, 教授 (10327918)
• Co-Investigator(Kenkyū-buntansha): 成相 直 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (00228090) ; 石井 賢二 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (10231135)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳血流量 / 有酸素運動 / 血圧変動 / 陽電子放出断層撮影 / 脳機能画像 / 陽電子放射断層撮影 / 脳血管自動調節能 / 神経画像 / 脳血流自動調節能 / 運動負荷 / 運動 / 血圧 / 脳・神経 / 生理学 / 陽電子放出断層撮像法

Outline of Final Research Achievements

Alteration of regional cerebral blood flow during and following dynamic aerobic exercise has been investigated using positron emission tomography(PET).
We investigated the associations between regional cerebral blood flow (rCBF) and increased blood pressure (BP) during exercise and decreased BP following the cessation of exercise. Our results demonstrated that large areas were related with rCBF and this finding was particularly eminent at the onset of exercise when the extent of increase in BP was large. However, when exercise continued, rCBF changed to the baseline level of the resting status in almost all of brain regions. In the present study, rCBF was investigated in conjunction with these changes in BP and cardiac output to explore the mechanism of regulating CBF during exercise.

Academic Significance and Societal Importance of the Research Achievements

本研究課題は脳に対する運動の影響を調べるために、実際の運動中の脳の局所血流量を陽電子放出断層撮影（positron emission tomography: PET）により解析した。一般的に脳血流量は血圧変動が生じた場合自動調節能により一定に保たれることが知られているが、実際には血圧変動を伴う有酸素運動中に血流量は脳の局所で20～50％程度増加し、終了後は10％程度減少することが明らかとなった。本研究により運動中の脳の血流量増加は神経可塑性などの有益な変化と関連し、運動後低血圧時の脳血流低下少なく脳虚血発作などのリスクとの関連は乏しいことが示唆された。

Research Products

• [Journal Article] Dynamic Exercise Elicits Dissociated Changes Between Tissue Oxygenation and Cerebral Blood Flow in the Prefrontal Cortex: A Study Using NIRS and PET. (2018)
  • Author(s): (12).Hiura, M., Nariai, T., Takahashi, K., Muta, A., Sakata, M., Ishibashi, K., Toyohara, J., Wagatsuma, K., Tago, T., Ishii, K., Maehara, T.
  • Journal Title: Adv Exp Med Biol. 2018 Aug 30;1072:269-274. Volume: 1072 Pages: 269-274
  • DOI: 10.1007/978-3-319-91287-5_43
  • ISBN: 9783319912851, 9783319912875
  • Peer Reviewed
• [Journal Article] Response of cerebral blood flow and blood pressure to dynamic exercise: A study using PET (2018)
  • Author(s): Hiura, M., Nariai, T. Muta, A., Sakata, M., Ishibashi, K. Toyohara, J. Wagatsuma, K. Tago, T., Ishii, K. Maehara, T.
  • Journal Title: International Journal of Sports Medicine Volume: 39 Issue: 03 Pages: 181-188
  • DOI: 10.1055/s-0043-123647
  • Peer Reviewed
• [Journal Article] PET imaging for altered brain function evoked by exercise: measurements of changes in cerebral blood flow and neurotransmitters (2017)
  • Author(s): 日浦幹夫、成相直、牟田光孝、稲次基希、豊原潤、坂田宗之、石井賢二、石橋賢士、我妻慧、織田圭一、石渡喜一、前原健寿
  • Journal Title: Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) Volume: 28 Issue: 2 Pages: 297-302
  • DOI: 10.16977/cbfm.28.2_297
  • NAID: 130006008234
  • ISSN: 0915-9401, 2188-7519
• [Journal Article] Central μ-opioidergic system activation evoked by heavy and severe-intensity cycling exercise in humans: a pilot study using positron emission tomography with 11C-carfentanil. (2017)
  • Author(s): Hiura M, Sakata M, Ishii K, Toyohara J, Oda K, Nariai T, Ishiwata K.
  • Journal Title: Int. J. Sports Med. Volume: 38 Issue: 01 Pages: 19-26
  • DOI: 10.1055/s-0042-114779
  • Peer Reviewed
• [Presentation] Alterations in cerebral blood flow evoked by dynamic exercise in post-stroke patients implies a mechanism for cerebral autoregulation: a PET study. (2019)
  • Author(s): 2.Hiura M, Nariai T, Sakata M, Muta A, Ishibashi K, Wagatsuma K, Tago T, Toyohara J, Ishii K, Katayama Y.
  • Organizer: Brain & Brain PET 2019
  • Int'l Joint Research
• [Presentation] Exercise-induced fluctuation in cerebral blood flow among patients with main arterial occlusions implies a mechanism for cerebral autoregulation: a pet study. (2019)
  • Author(s): 1.Hiura M, Nariai T, Sakata M, Muta A, Ishibashi K, Wagatsuma K, Tago T, Toyohara J, Ishii K, Katayama Y.
  • Organizer: 42nd ESNR Annual Meeting
  • Int'l Joint Research
• [Presentation] Redistribution of cerebral blood flow evoked by aerobic exercise is attributable to neuro-vascular coupling and cerebral autoregulation: A study using PET (2018)
  • Author(s): Hiura, M., Nariai, T., Sakata, M., Muta, A., Ishibashi, K., Toyohara, J., Wagatsuma, K., Tago, T., Ishii, K., Maehara, T., Katayama, Y.
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] 有酸素運動負荷時のPET計測による局所脳血流量とNIRS計測指標の差異の検討 (2018)
  • Author(s): 日浦幹夫
  • Organizer: 脳循環代謝サマーキャンプ2018
• [Presentation] 有酸素運動に伴う脳血流量変化の背景としての脳血管自動調節能と neurovascular couplingの考察；PET研究 (2018)
  • Author(s): (59).(60).日浦幹夫、成相直、坂田宗之、牟田光孝、石橋賢士、我妻慧、多胡哲郎、豊原潤、石井賢二、前原健寿、片山容一
  • Organizer: 第61回日本脳循環代謝学会学術集会
• [Presentation] Redistribution of cerebral blood flow evoked by exercise and cerebral autoregulation. (2018)
  • Author(s): (69).(71).Hiura, M., Nariai. T., Sakata, M., Muta, A., Ishibashi, K., Wagatsuma, K., Tago, T., Toyohara, J. Ishii, K., Maehara, T., Katayama, Y
  • Organizer: 第58回日本核医学回学術総会
• [Presentation] Regional cerebral blood flow correlated with changes in blood pressure evoked by dynamic exercise: A study using oxygen-15-labeled water with PET. (2017)
  • Author(s): Hiura, M., Sakata, M., Ishii, K., Ishibashi, K., Wagatsuma, K., Tago, T., Toyohara, J., Muta, A., Nariai, T.
  • Organizer: Brain 2017, Berlin
  • Int'l Joint Research
• [Presentation] 脳血管障害後リハビリテーションにおける有酸素運動の神経生理学的背景について：15O-H2Oを 用いた PET 研究の知見から (2017)
  • Author(s): 日浦幹夫、成相直、牟田光孝
  • Organizer: 第８回日本ニューロリハビリテーション学会学術集会（シンポジウム）
• [Presentation] Cerebral blood flow during dynamic exercise ccorrelates with blood pressure in autonomic brain regions (2017)
  • Author(s): Hiura, M., Muta, A., Sakata, M., Wagatsuma, K. Tago, T., Toyohara, J., Ishibashi, K., Ishii, K., Nariai, T.
  • Organizer: ACSM’s 64th Annual Meeting, Denver
  • Int'l Joint Research
• [Presentation] Correlation between cerebral blood flow and blood pressure during and post exercise is presented in central autonomic network; A positron emission tomography study using oxygen-15-labeled water. (2017)
  • Author(s): Hiura, M., Nariai, T. Sakata, M., Muta, A., Maehara, T. Ishibashi, K. Wagatsuma, K. Tago, T., Toyohara, J., Ishii, K
  • Organizer: 22th Annual Congress of the ECSS, MetropolisRuhr
  • Int'l Joint Research
• [Presentation] Dynamic exercise elicits dissociated changes between tissue oxygenation and cerebral blood flow in the prefrontal cortex: a study using NIRS and PET. (2017)
  • Author(s): Hiura, M., Nariai, T. Takahashi, K. Muta, A., Sakata, M., T. Ishibashi, K. Toyohara, J. Wagatsuma, K. Tago, T., Ishii, K. Maehara, T.
  • Organizer: ISOTT 2017, Halle
  • Int'l Joint Research
• [Presentation] Alteration of regional cerebral blood flow evoked by dynamic exercise among patients with ischemic cerebrovascular diseases; A Study using oxygen-15-labeled water with PET (2017)
  • Author(s): Hiura, M., Nariai, T. Muta, A., Sakata, M., Ishibashi, K. Toyohara, J. Wagatsuma, K. Tago, T., Ishii, K. Maehara, T.
  • Organizer: 40th ESNR Annual Meeting, Malmo
  • Int'l Joint Research
• [Presentation] 虚血性脳血管障害の患者群における運動負荷に対する脳血流変化の特性：H215Oを用いたPET研究 (2017)
  • Author(s): 日浦幹夫、成相直、牟田光孝、坂田宗之、我妻慧、多胡哲郎、石橋賢士、豊原潤、石井賢二
  • Organizer: 第57回日本核医学会学術総会
• [Presentation] 虚血性脳血管障害症例における有酸素運動に伴う脳循環応答の検討：H215Oを用いたPET研究の知見から (2017)
  • Author(s): 日浦幹夫、成相直、坂田宗之、牟田光孝、豊原潤、石橋賢士、我妻慧、多胡哲郎、石井賢二、前原健寿
  • Organizer: 第60回日本脳循環代謝学会学術総会
• [Presentation] 虚血性脳血管障害の既往がある患者群における運動負荷時局所脳血流量の検討; PET計測を用いた研究 (2017)
  • Author(s): 日浦幹夫、成相直、坂田宗之、牟田光孝、豊原潤、石橋賢士、我妻慧、石井賢二、前原健寿
  • Organizer: 第42回日本脳卒中学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
• [Presentation] 虚血性脳血管障害の症例における有酸素運動に伴う脳血流量変化について (2016)
  • Author(s): 日浦幹夫、牟田光孝、成相直
  • Organizer: 第27回日本臨床スポーツ医学会学術集会
  • Place of Presentation: 幕張メッセ国際会議場（千葉県千葉市）
• [Presentation] 低強度定常負荷運動の初期および後期における中大脳動脈支配領域の局所脳血流及び中大脳動脈平均脳血流速度の比較検討 (2016)
  • Author(s): 牟田光孝、日浦幹夫、成相直
  • Organizer: 第27回日本臨床スポーツ医学会学術集会
  • Place of Presentation: 幕張メッセ国際会議場（千葉県千葉市）
• [Presentation] PETイメージングを活用した運動負荷時の脳機能解析：脳血流と神経受容体計測の実際 (2016)
  • Author(s): 日浦幹夫、成相直、牟田光孝、稲次基希、豊原潤、石井賢二、石橋賢士、我妻慧、坂田宗之、織田圭一、石渡喜一、前原健寿
  • Organizer: 第59回日本脳循環代謝学会学術集会
  • Place of Presentation: あわぎんホール（徳島県徳島市）
• [Presentation] スポーツと脳循環代謝 (2016)
  • Author(s): 日浦幹夫
  • Organizer: 第59回日本脳循環代謝学会学術集会
  • Place of Presentation: あわぎんホール（徳島県徳島市）
  • Invited
• [Book] Advances in Experimental Medicine and Biology; (2018)
  • Author(s): Thews, Oliver, LaManna, Joseph, Harrison, David K. (Eds.)
  • Total Pages: 484
  • Publisher: Springer
  • ISBN: 9783319912851
• [Book] Physical Activity and the Aging Brain: Effects of Exercise on Neurological Function, Changes in Cerebral Blood Flow During Steady-State Exercise (Chapter 8) (2017)
  • Author(s): Ronald Ross Watson editor, M Hiura, T Nariai
  • Total Pages: 238
  • Publisher: Academic Press