| Project/Area Number |
16K01844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
FUKUO keisuke 武庫川女子大学, 生活環境学部, 教授 (40156758)
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| Co-Investigator(Kenkyū-buntansha) |
安田 修 鹿屋体育大学, スポーツ生命科学系, 教授 (00372615)
横路 三有紀 武庫川女子大学, 生活環境学部, 助教 (80757188)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Apoptogenic protein-1 / ミトコンドリア / エネルギー代謝 / 脂肪肝 / ミトコンドリア機能 / NAFLD / Apoptogenic protein 1 / 耐糖能異常 / 熱産生能 / 尿細管障害 / 脂質代謝 / Apoptgenic protein-1 / 高齢者 / 老化 / 腎臓病 / テーラーメード医療 |
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| Outline of Final Research Achievements |
In this study, we explored a role of apoptogenic protein-1 (Apop-1), which is a protein localized in mitochondria, in the mechanism of aging and age-related renal dysfunction. Apop-1 knockout mice (Apop-1KO) were fed a high-fat diet for 6 months. In the results, renal function was not changed between wild-type mice and Apop-1KO. Unexpectedly, high-fat diet induced-lipid accumulation in the liver was significantly prevented in Apop-1KO compared to wild-type. This result suggests that Apop-1 protein
may contribute to the fatty liver diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
脂肪肝は肝硬変や肝がんの原因となるが、その発症機序は明らかでない。最近、肥満や糖尿病の増加とともに脂肪肝の患者数が急増し、大きな社会問題となっている。本研究は、脂肪肝の発症メカニズムにミトコンドリア蛋白質であるApop-1が関わる可能性を示したものである。今後、Apop-1を標的とした脂肪肝の予防、治療法の開発が期待される。
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