| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Among the dangerous marine animals, the box jellyfish Habu-kurage is known with its severe stinging. The causative agents of severe pain by Habu-kurage were researched. Nematocyst was isolated from Habu-kurage, at first. Then, isolated nematocysts were extracted and the pure nematocyst contents were obtained. Now we are trying to isolate the pain causative agents from the isolated nematocysts of Habu-kurage. One of the Okinawan cyanobacteria is known as the causative organism of skin irritation. The skin irritation is caused by the toxins such as aplysiatoxins and lyngbyatoxins. We conducted the isolation of the cytotoxic compounds from this cyanobacterium. Finally, some new aplysiatoxin derivatives have been isolated and structurally elucidated. Also biological activity tests were accomplished on these new compounds.
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