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A survey of the action mechanism of new compound EH-1 that induces triple response in plants

Research Project

Project/Area Number 16K01936
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical biology
Research InstitutionAkita Prefectural University

Principal Investigator

Oh Keimei  秋田県立大学, 生物資源科学部, 准教授 (20300858)

Co-Investigator(Kenkyū-buntansha) 原 光二郎  秋田県立大学, 生物資源科学部, 准教授 (10325938)
鈴木 龍一郎  秋田県立大学, 生物資源科学部, 助教 (70632397)
上田 健治  秋田県立大学, 生物資源科学部, 准教授 (80279504)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords植物ホルモン / エチレン / 三重反応 / ピラゾール / 植物成長調節剤 / エチレンシグナル伝達機構 / トリプルレスポンス
Outline of Final Research Achievements

Plant hormones are important signal mediators that involve in plant growth and stress respones. In the present study, we aimed at identification of the action mechanism of a new chemical EH-1 which displays ethylene like activity.
To determine the action mechanism of EH-1,we used mutants of ethylene signaling transduction pathways together with mutants of auxin transduction pathways and chemicals that involves in auxin biosynthesis and auxin transport. Data obtained indicated that the biological activity of EH-1 that induces triple response in Arabidopsis is not due to the direct effect on the ethylene signaling. We found that the triple resopnse of in plants induced by EH-1 is due to the effect of EH-1 on auxin biosynthesis and auxin signaling.

Academic Significance and Societal Importance of the Research Achievements

エチレンの植物老化促進機能に基づく果実の追熟技術は広く利用されている。しかし、エチレンは極めて可燃性の高いガスであるゆえ、畑には直接使用することは困難である。本研究で開発したエチレン活性を示す化合物は、水に溶かして使用することができる。化合物の実用化研究により畑などで利用されることを期待したい。また、本研究で得られた成果は、エチレンとオーキシンのクローストーク解析に利用できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (28 results)

All 2020 2019 2018 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (22 results) (of which Int'l Joint Research: 9 results,  Invited: 4 results)

  • [Journal Article] Synthesis and structure-activity relationships of new pyrazole derivatives that induce triple response in <i>Arabidopsis</i> seedlings2019

    • Author(s)
      Oh Keimei、Hoshi Tomoki
    • Journal Title

      Journal of Pesticide Science

      Volume: 44 Issue: 4 Pages: 233-241

    • DOI

      10.1584/jpestics.D19-037

    • NAID

      130007748676

    • ISSN
      1348-589X, 1349-0923
    • Year and Date
      2019-11-20
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 植物ホルモン関連物質の利用に基づくダリア切り花品質保持技術の開発 -植物ホルモン生合成阻害剤の検討.2019

    • Author(s)
      王 敬銘, 山形 敦子
    • Journal Title

      秋田県立大学ウェブジャーナルB

      Volume: 6 Pages: 101-106

    • NAID

      120006734016

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 植物の「三重反応」形態を誘導する新規化合物の探索・作用機構解析研究2019

    • Author(s)
      王敬銘
    • Journal Title

      アグリバイオ

      Volume: 3 Pages: 40-43

    • Related Report
      2018 Research-status Report
  • [Journal Article] Analysis the action mechanism of pyrazole derivatives EH-1 that induces triple response in Arabidopsis seedlings by using RNA-sequencing2019

    • Author(s)
      Keimei Oh Kenji Ueda Kojiro Hara
    • Journal Title

      Int. J. Pharm. Med. Biol. Sci.

      Volume: 8 Issue: 2 Pages: 45-48

    • DOI

      10.18178/ijpmbs.8.2.45-48

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Chemical Genetics Strategy That Identifies Small Molecules Which Induce the Triple Response in Arabidopsis2017

    • Author(s)
      Keimei Oh ,Tomoki Hoshi, Sumiya Tomio, Kenji Ueda and Kojiro Hara
    • Journal Title

      Molecules

      Volume: 22 Issue: 12 Pages: 2270-2270

    • DOI

      10.3390/molecules22122270

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of imidazole and indole hybrid molecules and antifungal activity against rice blast.2017

    • Author(s)
      Sumiya Tomio, Mai Ishigaki Oh K.
    • Journal Title

      Int. J. Chem. Eng. & Appl.

      Volume: 8 Issue: 3 Pages: 233-236

    • DOI

      10.18178/ijcea.2017.8.3.662

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Synthesis and structure-activity relationships of new pyrazole derivatives that induce triple response in Arabidopsis seedlings.2020

    • Author(s)
      Keimei OH
    • Organizer
      11th International Conference of Chemistry and Chemical Process.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ブラシノステロイド生合成阻害剤ユカイゾールの作用機構解析2020

    • Author(s)
      冨尾 冴、渡辺 明夫、王 敬銘
    • Organizer
      第45回日本農薬学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Survey the action mechanism of pyrazole derivatives that induce triple response in Arabidopsis seedlings by using RNA-seq.2019

    • Author(s)
      Keimei Oh, Kenji Ueda and Kojiro Hara
    • Organizer
      The 2nd International Conference on Soil Remediation and Plant Protection
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery, SAR and action mechanism of new compounds that induce triple response in Arabidopsis seedlings.2019

    • Author(s)
      Keimei Oh, Tomoki Hoshi
    • Organizer
      IUPAC international synposium on bioorganic chemistry.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 植物の「三重反応」を誘導する化合物のライブラリースクリーニング2019

    • Author(s)
      王敬銘、星智樹
    • Organizer
      第14回ケミカルバイオロジー学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 植物の「三重反応」を誘導する新規プラゾール系化合物の構造活性相関研究2019

    • Author(s)
      王敬銘、星智樹
    • Organizer
      生体機能と創薬シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Survey the action mechanism of pyrazole derivatives that induce triple response in Arabidopsis seedlings by using RNA-seq.2019

    • Author(s)
      Keimei Oh, Kenji Ueda and Kojiro Hara
    • Organizer
      第8回生命医薬情報学連合大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 蛍光標識阻害剤YCZ-DFと遺伝子突然変異体を利用したブラシノステロイド生合成阻害剤の作用機構解析2019

    • Author(s)
      王 敬銘、冨尾 冴、渡辺 明夫
    • Organizer
      第54回植物化学調節学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A Chemical Genetics Strategy That Identifies Small Molecules Which Induce the Triple Response in Arabidopsis.2019

    • Author(s)
      Keimei Oh
    • Organizer
      9th International Conference on Biomedical Engineering and Technology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「植物ホルモンの機能を制御する物質の開発」2018

    • Author(s)
      王敬銘
    • Organizer
      日本農芸化学会2018年度東北支部シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Synthesis and Antimicrobial Activity of Functional Material with Imidazole and Indole Hybrid Structure2018

    • Author(s)
      Tomio Sumiya Keimei Oh
    • Organizer
      International conference on functional Material 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesis and Biological Evaluation the Fluorescent Probe of EH-1, a Pyrazole Derivative Displays Ethylene Activity that Induces Triple Response in Arabidopsis Seedlings2018

    • Author(s)
      Keimei Oh, Hirodai Fujita, Sumiya Tomio
    • Organizer
      International Conference on Biomedical Signal and Image Processing
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 植物の「三重反応」を誘導する蛍光プローブの合成と利用に関する研究2018

    • Author(s)
      王敬銘、藤田寛大、江崎奨吾、冨尾冴
    • Organizer
      日本農薬学会
    • Related Report
      2018 Research-status Report
  • [Presentation] CYP90s 遺伝子突然変異体を用いた YCZ 蛍光プローブの作用機構解析2018

    • Author(s)
      富尾 冴,星 智樹,渡辺明夫,王敬銘
    • Organizer
      日本農薬学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Chemical Genetics Strategy Identifies Small Molecules Induce Triple Response in Arabidopsis.2018

    • Author(s)
      Oh K
    • Organizer
      8th International Conference on Bioscience, Biochemistry and Bioinformatics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 植物の「三重反応」を誘導する蛍光プローブの合成と利用に関する研究2018

    • Author(s)
      王敬銘、藤田寛大、江崎奨吾、冨尾冴
    • Organizer
      日本農薬学会第43回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] エチレン活性を示す新規化合物の発見と作用機構解析研究2017

    • Author(s)
      王 敬銘,冨尾 冴,星 智樹, 原 光二郎,上田 健治,吉澤結子
    • Organizer
      日本農薬学会第42回大会
    • Place of Presentation
      愛媛大学(愛媛県、松山市)
    • Year and Date
      2017-03-06
    • Related Report
      2016 Research-status Report
  • [Presentation] エチレン活性を示す新規化合物の発見と作用機構解析研究.2017

    • Author(s)
      王 敬銘,冨尾冴,星智樹, 原光二郎,上田健治,吉澤結子
    • Organizer
      日本農薬学会第42回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] エチレン活性を示す化合物の開発と作用機構解析2017

    • Author(s)
      富尾 冴、王 敬銘
    • Organizer
      第52回大会植物化学調節学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Discovery of small molecules display ethylene activity through compound library screening2017

    • Author(s)
      Keimei Oh
    • Organizer
      XIX International Botanical Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discovery of Small Molecules Targeting Ethylene Signaling2016

    • Author(s)
      Keimei Oh
    • Organizer
      International Conference on Ecological Pesticides for Industry, Agriculture and Hygiene (EPIAH2016)
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2016-11-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] エチレン活性を示す新規化合物2016

    • Author(s)
      王敬銘,原光二郎,上田健治,鈴木龍一郎,星智樹,冨尾冴,吉澤結子
    • Organizer
      植物化学調節学会
    • Place of Presentation
      高知大学 (高知県、高知市)
    • Year and Date
      2016-10-28
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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