| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
We investigated the effects of addictive drugs on the white matter by focusing on changes in oligodendrocytes and axonal conduction. The effects of methamphetamine, cocaine, and nicotine were studied. We found that there were changes that were common to these drug administrations and changes that were not common. Moreover, we observed that acute and chronic exposure of same drug oppositely affect the axonal conduction. By functional examination of the changes in axonal conduction in myelinated fibers, we discovered the previously unappreciated effects of addictive drugs on the nervous system with their diversity.
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