| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Bioinformatics analysis was used to select candidate genes whose deletion would result in gene expression similar to that of psychiatric disease model mice, and for several of these genes, knockout mice were created in fertilized eggs of C57BL/6J using CRISPR/Cas9 genome editing technology.
The mouse which peculiarly manifested the photoactivation enzyme by adeno-associated virus inoculation in the hippocampus dentate gyrus was stimulated by the light. The mice performed better on some learning tasks. The activation of this enzyme is suggested to play a facilitative role in memory immobilization.
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