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Investigation of psychiatric disorders as a disruption of homeostasis

Research Project

Project/Area Number 16K01946
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionUniversity of Toyama

Principal Investigator

Takao Keizo  富山大学, 研究推進機構 研究推進総合支援センター, 教授 (80420397)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords行動解析 / 統合失調症 / 歯状回 / バイオインフォマティクス / 光遺伝学 / 脳科学
Outline of Final Research Achievements

Bioinformatics analysis was used to select candidate genes whose deletion would result in gene expression similar to that of psychiatric disease model mice, and for several of these genes, knockout mice were created in fertilized eggs of C57BL/6J using CRISPR/Cas9 genome editing technology.
The mouse which peculiarly manifested the photoactivation enzyme by adeno-associated virus inoculation in the hippocampus dentate gyrus was stimulated by the light. The mice performed better on some learning tasks. The activation of this enzyme is suggested to play a facilitative role in memory immobilization.

Academic Significance and Societal Importance of the Research Achievements

本研究によって樹立した遺伝子欠損マウスの系統は今後、精神疾患のモデルとなる可能性が高く、精神疾患の病態の解明や治療法の開発に活用できると期待される。また、光依存的に活性化する酵素を発現したマウスで、光刺激依存的に一部の学習課題の成績が向上していたことから、この酵素の活性化は記憶の固定化に促進的な役割を果たしていると示唆され、この酵素をターゲットとして認知症などの記憶障害の治療法の開発が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (65 results)

All 2019 2018 2017 2016

All Journal Article (23 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 23 results,  Open Access: 14 results) Presentation (42 results) (of which Int'l Joint Research: 9 results)

  • [Journal Article] Rapid and high-efficient generation of mutant mice using freeze-thawed embryos of the C57BL/6J strain2019

    • Author(s)
      Darwish Mohamed、Nishizono Hirofumi、Uosaki Hideki、Sawada Hitomi、Sadahiro Taketaro、Ieda Masaki、Takao Keizo
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 317 Pages: 149-156

    • DOI

      10.1016/j.jneumeth.2019.01.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Establishment of a Mouse Model of Atopic Dermatitis by Deleting Ikk2 in Dermal Fibroblasts2019

    • Author(s)
      Nunomura Satoshi、Ejiri Naoko、Kitajima Midori、Nanri Yasuhiro、Arima Kazuhiko、Mitamura Yasutaka、Yoshihara Tomohito、Fujii Kazuki、Takao Keizo、Imura Johji、Fehling Hans Joerg、Izuhara Kenji、Kitajima Isao
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 202X Issue: 6 Pages: 32926-9

    • DOI

      10.1016/j.jid.2018.10.047

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Open source code for behavior analysis in rodents2019

    • Author(s)
      Hattori Satoko、Okumura Yoshihiro、Takao Keizo、Yamaguchi Yoko、Miyakawa Tsuyoshi
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 39 Issue: 1 Pages: 67-69

    • DOI

      10.1002/npr2.12047

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice2019

    • Author(s)
      Ueno Hiroshi、Fujii Kazuki、Takao Keizo、Suemitsu Shunsuke、Murakami Shinji、Kitamura Naoya、Wani Kenta、Matsumoto Yosuke、Okamoto Motoi、Ishihara Takeshi
    • Journal Title

      Molecular and Cellular Neuroscience

      Volume: 95 Pages: 31-42

    • DOI

      10.1016/j.mcn.2018.12.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility.2019

    • Author(s)
      Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, Shirakawa H, Kaneko S.
    • Journal Title

      Brain Res.

      Volume: 1704 Pages: 68-77

    • DOI

      10.1016/j.brainres.2018.09.031

    • NAID

      120006630995

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chronic fentanyl administration on behavioral characteristics of mice2018

    • Author(s)
      Fujii Kazuki、Koshidaka Yumie、Adachi Mayumi、Takao Keizo
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 39 Issue: 1 Pages: 17-35

    • DOI

      10.1002/npr2.12040

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-22018

    • Author(s)
      Koshimizu Hisatsugu、Hirata Nao、TaIchinokao Keizo、Toyama Keiko、se Takashi、Furuya Shigeki、Miyakawa Tsuyoshi
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 39 Issue: 1 Pages: 56-60

    • DOI

      10.1002/npr2.12041

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery2018

    • Author(s)
      Katano Tayo、Takao Keizo、Abe Manabu、Yamazaki Maya、Watanabe Masahiko、Miyakawa Tsuyoshi、Sakimura Kenji、Ito Seiji
    • Journal Title

      Molecular Brain

      Volume: 11 Issue: 1 Pages: 63-63

    • DOI

      10.1186/s13041-018-0407-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex2018

    • Author(s)
      Ueno H, Fujii K, Suemitsu S, Murakami S, Kitamura N, Wani K, Aoki S, Okamoto M, Ishihara T, Takao K
    • Journal Title

      IBRO Rcports

      Volume: 4 Pages: 22-37

    • DOI

      10.1016/j.ibror.2018.01.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive behavioral analysis of tryptophan 2,3-dioxygenaso (Tdo2) knockout mice2018

    • Author(s)
      Hattori S, Takao K, Funakoshi H, *Miyakawa T
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 38 Issue: 2 Pages: 52-60

    • DOI

      10.1002/npr2.12006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dissociated role of D-serine in extinction during consolidation vs. reconsolidation of context conditioned fear.2018

    • Author(s)
      Inoue R, Talukdar G, Takao K, Miyakawa T, Mori H.
    • Journal Title

      Front Mol Neurosci.

      Volume: 11 Pages: 161-161

    • DOI

      10.3389/fnmol.2018.00161

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory2018

    • Author(s)
      Okuda Kosuke、Takao Keizo、Watanabe Aya、Miyakawa Tsuyoshi、Mizuguchi Masashi、Tanaka Teruyuki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 4 Pages: e0196587-e0196587

    • DOI

      10.1371/journal.pone.0196587

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex.2018

    • Author(s)
      Hiroshi Ueno, Kazuki Fujii, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Shozo Aoki, Motoi Okamoto, Takeshi Ishihara, Keizo Takao
    • Journal Title

      IBRO Reports

      Volume: ー

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex2018

    • Author(s)
      Ueno Hiroshi、Takao Keizo、Suemitsu Shunsuke、Murakami Shinji、Kitamura Naoya、Wani Kenta、Okamoto Motoi、Aoki Shozo、Ishihara Takeshi
    • Journal Title

      Neurochem Int

      Volume: 112 Pages: 59-70

    • DOI

      10.1016/j.neuint.2017.11.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis2017

    • Author(s)
      Yoshioka Nozomu、Miyata Shinji、Tamada Atsushi、Watanabe Yumi、Kawasaki Asami、Kitagawa Hiroshi、Takao Keizo、Miyakawa Tsuyoshi、Takeuchi Kosei、Igarashi Michihiro
    • Journal Title

      Mol Brain

      Volume: 10 Issue: 1 Pages: 47-47

    • DOI

      10.1186/s13041-017-0328-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease : analysis of Osaka mutation-knockin mice2017

    • Author(s)
      Umeda Tomohiro、Kimura Tetsuya、Yoshida Kayo、Takao Keizo、Fujita Yuki、Matsuyama Shogo、Sakai Ayumi、Yamashita Minato、Yamashita Yuki、Ohnishi Kiyouhisa、Suzuki Mamiko、Takuma Hiroshi、Miyakawa Tsuyoshi、Takashima Akihiko、Morita Takashi、Mori Hiroshi、Tomiyama Takami
    • Journal Title

      Acta Neuropathol Commun

      Volume: 5 Issue: 1 Pages: 59

    • DOI

      10.1186/s40478-017-0461-5

    • NAID

      120006371271

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019593

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice2017

    • Author(s)
      Umemura Mariko、Ogura Tae、Matsuzaki Ayako、Nakano Haruo、Takao Keizo、Miyakawa Tsuyoshi、Takahashi Yuji
    • Journal Title

      Front Behav Neurosci

      Volume: 11 Pages: 125-125

    • DOI

      10.3389/fnbeh.2017.00125

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased cohesion in the brain leads to defective synapse development and anxiety-related behavior2017

    • Author(s)
      Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T.
    • Journal Title

      J. Exp. Med.

      Volume: 印刷中 Issue: 5 Pages: 1431-1452

    • DOI

      10.1084/jem.20161517

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis2017

    • Author(s)
      Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A
    • Journal Title

      Journal of Neurochemistry

      Volume: 141 Issue: 1 Pages: 124-136

    • DOI

      10.1111/jnc.13963

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] QRFP-deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior2016

    • Author(s)
      Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 11 Pages: e0164716-e0164716

    • DOI

      10.1371/journal.pone.0164716

    • NAID

      120007129233

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distribution of silver nanoparticles to breast milk and their biological effects on breast-fed offspring mice2016

    • Author(s)
      Morishita Y, Yoshioka Y, Takimura Y, Shimizu Y, Namba Y, Nojiri N, Ishizaka T, Takao K, Yamashita F, Takuma K, Ago Y, Nagano K, Mukai Y, Kamada H, Tsunoda SI, Saito S, Matsuda T, Hashida M, Miyakawa T, Higashisaka K, Tsutsumi Y
    • Journal Title

      ACS Nano

      Volume: 10 Issue: 9 Pages: 8180-91

    • DOI

      10.1021/acsnano.6b01782

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cohort removal induces changes in body temperature, pain sensitivity, and anxiety-like behavior.2016

    • Author(s)
      Takao K, Shoji H, Hattori S, Miyakawa T.
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 10 Pages: 99-99

    • DOI

      10.3389/fnbeh.2016.00099

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine2016

    • Author(s)
      Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S,
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 27204-27204

    • DOI

      10.1038/srep27204

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Effects of chronic fentanyl administration on behavioral characteristics of mice2019

    • Author(s)
      藤井一希, 腰高由美恵, 安達真由美, 高雄啓三
    • Organizer
      平成30年度文部科学省新学術領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ストレス応答性翻訳制御因子NFAR2 の天然変性領域欠損マウスの網羅的行動解析2019

    • Author(s)
      山下 映、藤井 一希、腰高由美恵、安達真由美、笹川恵理、中川真一、高雄啓三、椎名伸之
    • Organizer
      平成30年度文部科学省新学術領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 行動学的解析支援-大規模行動解析データの二次利用方法と行動解析用ソフトウエアの紹介2019

    • Author(s)
      服部聡子, 昌子浩孝, 高雄啓三, 宮川 剛
    • Organizer
      平成30年度文部科学省新学術領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] IgA 欠損マウスにおける生体機能に関する解析2019

    • Author(s)
      安達貴弘, 高雄啓三, 永石宇司, 渡部太郎
    • Organizer
      平成30年度文部科学省新学術領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ストレス応答性翻訳制御因子NFAR2の天然変性領域欠損マウスの網羅的行動解析2018

    • Author(s)
      山下 映, 藤井一希, 腰高由美恵, 安達真由美, 笹川恵理, 中川真一, 高雄啓三、椎名伸之
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Repulsive axon guidance molecule FLRT2 regulates neuronal migration and social behavior.2018

    • Author(s)
      S. Yamagishi, Y. Shinoda, S. Ogawa, T. Miyakawa, K. Takao, K. Sato
    • Organizer
      48th Annual meeting of Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protein distributionand functional characterization of CASK-interacting protein 1 (Caskin1) in mice.2018

    • Author(s)
      T. Katano, K. Takao, M. Abe, M. Yamazaki, M. Watanabe, T. MIiyakawa, K. Sakimura, S. Ito
    • Organizer
      48th Annual meeting of Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generation of glycine receptor alpha 4 knockout mice using high-efficient modified CRISPR-Cas9 protocol.2018

    • Author(s)
      M. I. Darwish, K. Uno, K. Takao, H. Nishizono
    • Organizer
      48th Annual meeting of Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pelizaeus-Merzbacher disease様ヒト先天性大脳白質形成不全症に関わるグリシンレセプターα4ノックアウトマウスの作製と病熊解析 Generation and characterization of glycine receptor algha 4 subunit (Glra4) knockout mice.2018

    • Author(s)
      西園啓文, Darwish Mohamed lbrahem, 澤田瞳子, 高雄啓三
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cdkl5ノックアウトマウスの網羅的行動解析の結果、不安・恐怖関連行動の著しい亢進、うつ様行動と社会性の特異な変化と、空間記憶の獲得と保持の障害が明らかとなった。2018

    • Author(s)
      田中輝幸, 奥田耕助, 高雄啓三, 渡邉 紀, 水口 雅, 宮川 剛
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] CASK-interacting_protein 1 (Gaskin 1)の中枢神経系における機能的特徴の解析2018

    • Author(s)
      片野泰代, 高雄啓三, 阿部 学, 山崎真弥, 渡辺雅彦, 宮川 剛, 崎村建司, 伊藤誠二
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ミクログリアに発現する電位依存性プロトンチャンネルの加齢依存的な機能2018

    • Author(s)
      河合喬文, 高雄啓三, 崎村健司, 宮川 剛 , 岡村康司
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経軸索ガイダンス分子FLRT2による社会性行動制御 Repulsive axon guidance molecule FLRT2 regulates neuronal migration and Social Behavior2018

    • Author(s)
      山岸 覚, 篠田陽, 小川修平, 宮川 剛 , 高雄啓三, 佐藤康二
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 精神疾患モデルマウスにおける軽度慢性炎症2018

    • Author(s)
      高雄啓三
    • Organizer
      第8回オルソオルガノジェネシス検討会
    • Related Report
      2018 Annual Research Report
  • [Presentation] APPノックインマウスの若齢期における行動表現型解析2018

    • Author(s)
      木村公洋, 藤井一希, 腰高由美恵, 安達真由美, 松尾美奈, 柳橋裕子, 斉藤貴志, 西道隆臣, 高雄啓三
    • Organizer
      第65回日本実験動物学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 合成オピオイドフェンタニルの慢性投与がマウスの行動特性に与える影響2018

    • Author(s)
      藤井一希, 腰高由美恵, 安達真由美, 高雄啓三
    • Organizer
      第65回日本実験動物学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス大脳皮質におけるアグリカン陽性ペリニューロナルネットの発現2018

    • Author(s)
      上野浩司, 高雄啓三, 藤井一希, 末光俊介, 岡本基, 石原武士
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Behavioral physiological approach to the pathology and treatment of psychiatric disorders2018

    • Author(s)
      高雄 啓三
    • Organizer
      第8回新潟大学脳研究所共同研究拠点国際シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 遺伝子改変マウスの行動解析を起点とした精神疾患研究2017

    • Author(s)
      高雄 啓三
    • Organizer
      2017年度 生命科学系学会合同年次大会 ConBio2017
    • Related Report
      2017 Research-status Report
  • [Presentation] ノンコードゲノム領域の機能理解へのGenome Architectureの試み2017

    • Author(s)
      北野翔平, 金子真也, 高雄啓三, 相澤康則
    • Organizer
      2017年度生命科学系学会合同年次大会 ConBio2017
    • Related Report
      2017 Research-status Report
  • [Presentation] マウス大脳皮質におけるパルブアルブミンニューロンと神経細胞周囲網の年齢に関連した変化2017

    • Author(s)
      上野浩司, 高雄啓三, 末光俊介, 岡本 基, 石原武士
    • Organizer
      2017年度生命科学系学会合同年次大会 ConBio2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Mouse behavioral phenotype database. Advances in Neuroinformatics2017

    • Author(s)
      Hattori S, Shoji H, Takao K, Miyakawa T
    • Organizer
      Advances in Neuroinformatics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bidirectional role of postsynaptic cAMP and cGMP in synaptic plasticity and memory2017

    • Author(s)
      Borovac J, Luyben T, Takao K, Okamoto K
    • Organizer
      47th Annual meeting of Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus, and regulates seizure susceptibility, as well as emotional behaviors and memory2017

    • Author(s)
      Tanaka T, Okuda K, Kobayashi S, Fukaya M, Takao K, Watanabe A, Murakami T, Hagiwara M, Komano- Inoue S, Manabe H, Yamaguchi M, Sakagami H, Miyakawa T, Mizuguchi M, Manabe T
    • Organizer
      47th Annual meeting of Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 「こころ」の物質的基盤を探る行動生理学的アプローチ2017

    • Author(s)
      高雄啓三
    • Organizer
      第9回 光操作研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] シプナスオーガナイザー遺伝子点変異導入マウスを用いた神経発達障害発症機構の解明2017

    • Author(s)
      吉田知之、山形敦史、田端彩子、和泉宏謙、城島知子、金 主賢、深田優子、深田正紀、高雄啓三、森 寿、深井周也
    • Organizer
      第39回日本生物学的精神医学会,第47回日本神経精神薬理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 恒常性維持機構の破綻としての精神疾患2017

    • Author(s)
      高雄啓三
    • Organizer
      第7回オルソオルガノジェネシス検討会
    • Related Report
      2017 Research-status Report
  • [Presentation] 空間弁別に必要なセプチン依存的シナプス制御2017

    • Author(s)
      上田(石原)奈津実, 深澤有吾, 鈴木悠大, 増田啓吾, 高雄啓三, 宮川 剛, 尾藤晴彦, 木下 専
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] West 症候群・Rett 症候群の原因遺伝子CDKL5の相互作用蛋白探索とloss-of -function 解析による統合的機能解明2017

    • Author(s)
      田中輝幸, 奥田耕助, 小林静香, 村上拓冬, 深谷昌弘, 高雄啓三, 渡邊 紀, 萩原 舞, 阪上洋行, 水口 雅, 宮川 剛, 真鍋俊也
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 転写因子ATF5の欠損は行動異常を引き起こす2017

    • Author(s)
      梅村真理子, 小倉多恵, 金子泰之, 中野春男, 高橋 滋, 高雄啓三, 宮川 剛, 高橋勇二
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 統合失調症モデル Schnurri-2 ノックアウトマウスの歯状回顆粒細胞における三次元電子顕微鏡解析2017

    • Author(s)
      中尾章人, 高雄啓三, 大平耕司, 宮崎直幸, 村田和義, 宮川 剛
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] オーファン代謝型受容体 Prrt 3の大脳特異的ノックアウトマウスの行動解析、およびそのリガンド同定に向けた小分子ライブラリーのスクリーニング2017

    • Author(s)
      陳 以珊, 山本友美, 周 麗, 夏目里恵, 今野幸太郎, 上杉志成, 渡辺雅彦, 高雄啓三, 宮川 剛, 崎村健司, 久保義弘
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ミクログリアに発現する電位依存性プロトンチャネルの脳内における発現差異とその機能2017

    • Author(s)
      河合喬文, 高雄啓三, 崎村健司, 宮川 剛, 岡村康司
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] マウスはやはりヒト炎症性疾患のモデルになる -バイオインフォマティクス的手法によるマウスモデルの再評価-2016

    • Author(s)
      Keizo Takao
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Three-dimensional analysis of dendritic spines and mitochondria in dentate gyrus granule cells in Schnurri-2 knockout mice, an animal model for schizophrenia2016

    • Author(s)
      Nakao A, Takao K2, Ohira K, Miyazaki N, Murata K, Miyakawa T
    • Organizer
      46th Annual meeting of Society for Neuroscience
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of R-type calcium channel (Cav2.3) in medial habenula to interpeduncular nucleus pathway2016

    • Author(s)
      Bhandari P, Parajuli LK, Takao K, Miyakawa T, Kobayashi Y, Tanaka KF, Shigemoto R
    • Organizer
      46th Annual meeting of Society for Neuroscience
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tutorial contents on neuroinfomrmatics platforms. 46th Annual meeting of Society for Neuroscience2016

    • Author(s)
      Yamaguchi Y, Hattori S, Takao K, Okumura Y, Suenaga S, Ishii I, Honda A, Ogawa M, Usui S, Miyakawa T
    • Organizer
      46th Annual meeting of Society for Neuroscience
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] RNG105 ヘテロマウスの網羅的行動解析―社会的相互作用・新奇対象への反応の低下2016

    • Author(s)
      大橋りえ,高雄啓三,宮川剛, 椎名伸之
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] West症候群・Rett症候群の原因遺伝子CDKL5は後シナプスNMDA受容体局在を制御し、記憶・学習、情動、易痙攣性を調節する2016

    • Author(s)
      村上拓冬, 奥田耕助, 小林静香, 深谷昌弘, 高雄啓三, 渡邉紀, 萩原舞, 阪上洋行, 水口雅 , 宮川剛, 真鍋俊也, 田中輝幸
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 自閉症様行動を示すFcγRIIB欠損マウスはPerineuronal netsの発現が変化している2016

    • Author(s)
      上野浩司, 横内美保子, 石原武士,末光俊介, 高雄啓三, 宮川剛, 岡本基
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] マウスモデルを用いた統合失調症研究の可能性2016

    • Author(s)
      高雄啓三
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Mouse Behavioral Phenotype Database2016

    • Author(s)
      Satoko Hattori , Hirotaka Shoji , Keizo Takao , Tsuyoshi Miyakawa
    • Organizer
      INCF Japan International Workshop: Advances in Neuroinformatics
    • Place of Presentation
      理化学研究所(埼玉県和光市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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