Investigation of psychiatric disorders as a disruption of homeostasis
Project/Area Number |
16K01946
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Basic / Social brain science
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Research Institution | University of Toyama |
Principal Investigator |
Takao Keizo 富山大学, 研究推進機構 研究推進総合支援センター, 教授 (80420397)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 行動解析 / 統合失調症 / 歯状回 / バイオインフォマティクス / 光遺伝学 / 脳科学 |
Outline of Final Research Achievements |
Bioinformatics analysis was used to select candidate genes whose deletion would result in gene expression similar to that of psychiatric disease model mice, and for several of these genes, knockout mice were created in fertilized eggs of C57BL/6J using CRISPR/Cas9 genome editing technology. The mouse which peculiarly manifested the photoactivation enzyme by adeno-associated virus inoculation in the hippocampus dentate gyrus was stimulated by the light. The mice performed better on some learning tasks. The activation of this enzyme is suggested to play a facilitative role in memory immobilization.
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Academic Significance and Societal Importance of the Research Achievements |
本研究によって樹立した遺伝子欠損マウスの系統は今後、精神疾患のモデルとなる可能性が高く、精神疾患の病態の解明や治療法の開発に活用できると期待される。また、光依存的に活性化する酵素を発現したマウスで、光刺激依存的に一部の学習課題の成績が向上していたことから、この酵素の活性化は記憶の固定化に促進的な役割を果たしていると示唆され、この酵素をターゲットとして認知症などの記憶障害の治療法の開発が期待される。
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility.2019
Author(s)
Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, Shirakawa H, Kaneko S.
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Journal Title
Brain Res.
Volume: 1704
Pages: 68-77
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Decreased cohesion in the brain leads to defective synapse development and anxiety-related behavior2017
Author(s)
Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T.
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Journal Title
J. Exp. Med.
Volume: 印刷中
Issue: 5
Pages: 1431-1452
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] QRFP-deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior2016
Author(s)
Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
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Journal Title
PLoS ONE
Volume: 11
Issue: 11
Pages: e0164716-e0164716
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Distribution of silver nanoparticles to breast milk and their biological effects on breast-fed offspring mice2016
Author(s)
Morishita Y, Yoshioka Y, Takimura Y, Shimizu Y, Namba Y, Nojiri N, Ishizaka T, Takao K, Yamashita F, Takuma K, Ago Y, Nagano K, Mukai Y, Kamada H, Tsunoda SI, Saito S, Matsuda T, Hashida M, Miyakawa T, Higashisaka K, Tsutsumi Y
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Journal Title
ACS Nano
Volume: 10
Issue: 9
Pages: 8180-91
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine2016
Author(s)
Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S,
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 27204-27204
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus, and regulates seizure susceptibility, as well as emotional behaviors and memory2017
Author(s)
Tanaka T, Okuda K, Kobayashi S, Fukaya M, Takao K, Watanabe A, Murakami T, Hagiwara M, Komano- Inoue S, Manabe H, Yamaguchi M, Sakagami H, Miyakawa T, Mizuguchi M, Manabe T
Organizer
47th Annual meeting of Society for Neuroscience
Related Report
Int'l Joint Research
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[Presentation] West 症候群・Rett 症候群の原因遺伝子CDKL5の相互作用蛋白探索とloss-of -function 解析による統合的機能解明2017
Author(s)
田中輝幸, 奥田耕助, 小林静香, 村上拓冬, 深谷昌弘, 高雄啓三, 渡邊 紀, 萩原 舞, 阪上洋行, 水口 雅, 宮川 剛, 真鍋俊也
Organizer
第40回日本神経科学大会
Related Report
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[Presentation] オーファン代謝型受容体 Prrt 3の大脳特異的ノックアウトマウスの行動解析、およびそのリガンド同定に向けた小分子ライブラリーのスクリーニング2017
Author(s)
陳 以珊, 山本友美, 周 麗, 夏目里恵, 今野幸太郎, 上杉志成, 渡辺雅彦, 高雄啓三, 宮川 剛, 崎村健司, 久保義弘
Organizer
第40回日本神経科学大会
Related Report
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[Presentation] West症候群・Rett症候群の原因遺伝子CDKL5は後シナプスNMDA受容体局在を制御し、記憶・学習、情動、易痙攣性を調節する2016
Author(s)
村上拓冬, 奥田耕助, 小林静香, 深谷昌弘, 高雄啓三, 渡邉紀, 萩原舞, 阪上洋行, 水口雅 , 宮川剛, 真鍋俊也, 田中輝幸
Organizer
第39回日本神経科学大会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-07-20
Related Report
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[Presentation] Mouse Behavioral Phenotype Database2016
Author(s)
Satoko Hattori , Hirotaka Shoji , Keizo Takao , Tsuyoshi Miyakawa
Organizer
INCF Japan International Workshop: Advances in Neuroinformatics
Place of Presentation
理化学研究所(埼玉県和光市)
Year and Date
2016-05-28
Related Report