Analysis of neural circuitry and regulatory mechanisms of social behavior adjustment to social environment
| Project/Area Number |
16K01948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 社会性行動 / マウスモデル |
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| Outline of Final Research Achievements |
We have shown that behavioral alterations observed in model mouse that mimics Williams Beuren syndrome, a developmental neuropsychiatric disorder in humans in humans may be caused by alterations in neural circuitry involving prefrontal cortex and thalamus and in neuromodulatory system including oxytocin and vasopressin.
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| Academic Significance and Societal Importance of the Research Achievements |
ウィリアムス・ビューレン症候群は染色体のある領域の欠損で起こる過剰な社会性行動を特徴とする疾患で、自閉症の対極をなす症状を示すものとして注目されて来た。過剰な社会性行動を含む様々な社会性行動の異常は自閉症をはじめ様々な精神疾患に伴って見られる行動表現型であるが、その異常に前頭前野や視床を含む脳神経回路やその調節系であるオキシトシンやバゾプレシンの発達異常が関与している可能性が示唆された。
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Report
(4 results)
Research Products
(21 results)
