| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
STX1A is known to regulate synaptic vesicle exocytosis. We found that STX1A gene might be implicated in autistic spectrum disorder. In STX1A gene knockout mice (STX1A KO), unusual behavioral properties including impairment of social recognition memory was observed. We demonstrated that STX1A KO exhibited reduction of oxytocin (OXT) release in CNS. We analyzed the regulation of social behavior by OXT using STX1A KO as a model animals. We found that the effect of OXT was related with DAergic system, and reciprocal interaction between OXTergic and DAergic system played important roles for regulation of social behavior.
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