Compartment specific modulation with intrinsic acetylcholine in the dorsal and caudal striatum of mice
| Project/Area Number |
16K01957
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Miura Masami 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (40291091)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アセチルコリン / オピオイド / ドーパミン / 大脳基底核 / 線条体 / 機能領域 / 恐怖条件付け |
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| Outline of Final Research Achievements |
Cholinergic interneurons substantially regulate physiological functions of the striatum. We investigated the ionic mechanisms controlling the neural activity of the cholinergic neurons and the regional effects of nicotinic receptors on synaptic transmissions in the caudal striatum. Excitatory glutamatergic inputs to the cholinergic neurons were suppressed by high frequency stimulation in conjunction with an agonist of mu opioid receptors. The prolonged suppression was eminent in the medial part of the striatum and disturbed by an α4β2 nAChR antagonist, suggesting the involvement of intrinsic acetylcholine. The synergistic effect of acetylcholine and opioid was heterogeneously observed with medio-lateral axes. Considering the synergistic effect of opioid and intrinsic acetylcholine on the synaptic plasticity there might be a regional diversity in the effect of acetylcholine on the reinforcement learning and adaptive behaviors.
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| Academic Significance and Societal Importance of the Research Achievements |
線条体は、運動から行動、情動といった多くの機能を担っている。そのため多くの疾患にも関わる。ドーパミンやアセチルコリンは線条体の強力な調節因子であるが、線条体全てに強く作用してしまうため、運動だけ、あるいは行動異常だけを治療することは困難である。。機能領域に特異的な生理的、薬理的作用が分かれば、特定の機能だけを調節できる可能性がある。新たな治療法のために役立つ情報といえる。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Leucine-rich α2-glycoprotein overexpression in the brain contributes to memory impairment2017
Author(s)
2.Akiba C, Nakajima M, Miyajima M, Ogino I, Miura M, Inoue R, Nakamura E, Kanai F, Tada N, Kunichika M, Yoshida M, Nishimura K, Kondo A, Sugano H, Arai H.
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Journal Title
Neurobiology of Aging
Volume: 60
Pages: 11-19
DOI
Related Report
Peer Reviewed / Open Access
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