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Adaptive changes of neuron ensemble activities under neural operant conditioning

Research Project

Project/Area Number 16K01966
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Brain biometrics
Research InstitutionKyoto Sangyo University

Principal Investigator

ITO Hiroyuki  京都産業大学, 情報理工学部, 教授 (80201929)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsブレイン・マシン・インタフェース / ニューロン・オペラント・コンディショニング / 多細胞活動記録 / 視覚皮質 / 多細胞データ / 発火数相関 / デコーディング / 内因性多様体 / ニューラルオペラントコンディショニング / ブレインマシンインタフェース / 多次元ガウスモデル / ディコーディング / ニューロンオペラントコンディショニング / BMI / 細胞集団 / バイオフィードバック
Outline of Final Research Achievements

As for the plasticity and the learning in the cortical activities, the neuron ensemble in the microscopic level often changes their activity patterns adaptively to the imposed constraint of the external environment in the macroscopic level(such as the amount of the rewards). In order to explore the basic principle behind these phenomena, we developed the experimental setup of the neural operant conditioning targeting the neuron ensemble activities of Cat visual cortex. We also developed the method for chronic recordings of multiple cortical neurons and investigated the statistical analysis of information decoding based on the population activities of the multiple neurons.

Academic Significance and Societal Importance of the Research Achievements

皮質活動における可塑性や学習において、ミクロな神経ネットワークレベルにおいて細胞集団がどのような原理でマクロな拘束(報酬など)との因果関係を捉えて、適応的な変化を生じるのかは根源的な問題である。本研究で構築を行ったNeuron Operant Conditioning実験は脳の適応現象の原理探求において最適な実験系である。今回完成した実験系を用いて本格的なNeuron Operant Conditioning実験を開始することで脳の適応現象の解明が進むことが期待される。この適応原理の理解は、脳疾患や脳損傷患者に対して脳と外界との相互作用を用いたバイオフィードバック治療に貢献すると考える。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2020 2019 2018 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Journal Article] Self-reorganization of neuronal activation patterns in the cortex under brain-machine interface and neural operant conditioning2020

    • Author(s)
      H.Ito, S.Fujiki, Y.Mori, K.Kansaku
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 23-28

    • DOI

      10.1016/j.neures.2020.03.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 認知課題における視線情報がミラーニューロンシステムに及ぼす影響2020

    • Author(s)
      物部太夢、伊藤浩之
    • Journal Title

      電子情報通信学会信学技報 IEICE Technical Report

      Volume: NC2019-83 Pages: 11-16

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Assessing the impacts of correlated variability with dissociated timescales2019

    • Author(s)
      T.Takahashi, Y.Maruyama, H.Ito and K.Miura
    • Journal Title

      eNeuro

      Volume: 6, 0395-18 Issue: 1 Pages: 1-16

    • DOI

      10.1523/eneuro.0395-18.2019

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ネコ視覚皮質での多細胞活動を用いた刺激方位推定 -発火数相関の効果-2019

    • Author(s)
      幸野怜歩、森 理也、伊藤浩之
    • Journal Title

      電子情報通信学会信学技報

      Volume: NC2018-76 Pages: 175-180

    • Related Report
      2018 Research-status Report
  • [Journal Article] 非線形物理学からみたニューラルネットワークの学習2018

    • Author(s)
      伊藤浩之、青柳富誌生
    • Journal Title

      学会誌「人工知能」

      Volume: 第33巻 Pages: 403-411

    • Related Report
      2018 Research-status Report
  • [Journal Article] Design of multielectrode arrays for uniform sampling of differently orientations of tuned unit populations in the cat visual cortex2017

    • Author(s)
      Yoshiko Maruyama and Hiroyuki Ito
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 51-63

    • DOI

      10.1016/j.neures.2017.04.004

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Decoding of stimulus orientations by neuron populations in Cat visual cortex -Contribution of spike count correlation-2020

    • Author(s)
      H.Ito, Y.Mori
    • Organizer
      The 6th CiNet Conference: Brain-Machine Interface -Medical Engineering based on Neuroscience
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 認知課題における視線情報がミラーニューロンシステムに及ぼす影響2020

    • Author(s)
      物部太夢、伊藤浩之
    • Organizer
      電子情報通信学会NC研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of multi-tetrode array with integrated miniature manipulator derive2019

    • Author(s)
      Y.Mori, H.Ito
    • Organizer
      42th Annual meeting of Japan Society of Neuroscience
    • Related Report
      2019 Annual Research Report
  • [Presentation] Decoding of stimulus orientations by neuron populations in Cat visual cortex -Contribution of spike count correlation-2019

    • Author(s)
      H.Ito, R.Kohno, Y.Maruyama, Y.Mori
    • Organizer
      42th Annual meeting of Japan Society of Neuroscience
    • Related Report
      2019 Annual Research Report
  • [Presentation] ネコ視覚皮質での多細胞活動を用いた刺激方位推定 -発火数相関の効果-2019

    • Author(s)
      幸野怜歩、森 理也、伊藤浩之
    • Organizer
      電子情報通信学会NC研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Assessing the impacts of correlated V1 activities with different mechanisms2018

    • Author(s)
      T.Takahashi, Y.Maruyama, H.Ito and K.Miura
    • Organizer
      Society for Neuroscience 2018 Annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] From Heart to Brain -Exploring Causality in Brain by Brain-Machine Interface2018

    • Author(s)
      H.Ito
    • Organizer
      Leon Glass and Michael Mackey Diamond Symposium: Nonlinear Mathematics in Medicine and Biology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ネコ視覚皮質での多細胞活動を用いた刺激方位推定 -発火数相関の効果-2018

    • Author(s)
      幸野怜歩、森 理也、伊藤浩之
    • Organizer
      視覚科学フォーフラム2018 第22回研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] CNNを用いた多チャンネル脳波データからの視覚刺激弁別2018

    • Author(s)
      物部太夢、伊藤浩之
    • Organizer
      電子情報通信学会NC研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Assessing the impacts of correlated V1 activities with different mechanisms2017

    • Author(s)
      T.Takahashi, Y.Maruyama, H.Ito, K.Miura
    • Organizer
      40th Annual meeting of Japan Society of Neuroscience
    • Related Report
      2017 Research-status Report
  • [Presentation] What factors influence homogeneous samplings of orientation tuned cells in the cat primary visual cortex?2017

    • Author(s)
      Y.Maruyama, H.Ito
    • Organizer
      40th Annual meeting of Japan Society of Neuroscience
    • Related Report
      2017 Research-status Report
  • [Presentation] Non-stationary and endogenous dynamics of synchronous oscillatory spike activities in the Cat lateral geniculate nucleus2016

    • Author(s)
      Hiroyuki Ito
    • Organizer
      Mini-symposium of HFO and Oscillology
    • Place of Presentation
      京都大学病院芝蘭会館(京都府京都市左京区)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2021-02-19  

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