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Relation between neuronal activity in the basal ganglia and voluntary movements regulated by striatal signal transduction.

Research Project

Project/Area Number 16K01968
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Brain biometrics
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

Sano Hiromi  生理学研究所, システム脳科学研究領域, 助教 (00363755)

Research Collaborator KOBAYASHI kenta  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords随意運動 / 大脳基底核 / 神経生理学 / シグナル伝達 / 線条体 / 神経活動 / ウイルスベクター / 脳・神経 / 神経科学 / 生理学
Outline of Final Research Achievements

The striatum is one of the input nuclei of the basal ganglia and supposed to regulate voluntary movements. Striatal projection neurons receive information by neurotransmitters which are released from the other nuclei of the basal ganglia. After receive the neurotransmitter, signal molecules in the striatum are activated and striatal projection neurons send the information to other brain regions. To clarify the relation between activity of the signal molecule, neuronal activity of the basal ganglia and voluntary movements, we used gene transfer technique to express the dominant active form of the signal molecule in the striatum and recorded behavioral changes and neuronal activities. The dominant active form of the signal molecule in the striatum increased information flow from the striatum and facilitated voluntary movements.

Academic Significance and Societal Importance of the Research Achievements

大脳基底核はパーキンソン病やハンチントン舞踏病などの重度な運動障害を示す疾患と深く関わっており、線条体は創薬の標的となってきた領域である。線条体におけるシグナル伝達分子を活性化させたところ、線条体からの信号を増強し、運動を増加させたという研究成果を得たが、この結果は、このシグナル伝達分子が創薬の標的となることを示唆している。この研究成果を元に、シグナル伝達分子に作用する化合物などが合成されれば、大脳基底核に関連する運動障害を示す疾患の治療に繋がる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (35 results)

All 2019 2018 2017 2016

All Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (25 results) (of which Int'l Joint Research: 12 results,  Invited: 6 results)

  • [Journal Article] The effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice2019

    • Author(s)
      Sano Hiromi、Nambu Atsushi
    • Journal Title

      Neurochemistry International

      Volume: 124 Pages: 171-180

    • DOI

      10.1016/j.neuint.2019.01.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: the role of trigeminal nerve transient receptor potential vanilloid 4.2019

    • Author(s)
      Okada Y, Sumioka T, Ichikawa K, Sano H, Nambu A, Kobayashi K, Uchida K, Suzuki Y, Tominaga M, Reinach PS, Hirai SI, Jester JV, Miyajima M, Shirai K, Iwanishi H, Kao WW, Liu CY, Saika S.
    • Journal Title

      Lab Invest.

      Volume: 99(2) Issue: 2 Pages: 210-230

    • DOI

      10.1038/s41374-018-0118-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration.2018

    • Author(s)
      Kaneko N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Nambu A, Kawaguchi Y, Garcia-Verdugo JM, Sawamoto K.
    • Journal Title

      Science Advances

      Volume: 4 Issue: 12 Pages: 0618-0618

    • DOI

      10.1126/sciadv.aav0618

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways2018

    • Author(s)
      Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M
    • Journal Title

      Neuron

      Volume: 99(6) Issue: 6 Pages: 1302-1314

    • DOI

      10.1016/j.neuron.2018.08.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optogenetic Activation of the Sensorimotor Cortex Reveals “Local Inhibitory and Global Excitatory” Inputs to the Basal Ganglia2017

    • Author(s)
      Ozaki Mitsunori、Sano Hiromi、Sato Shigeki、Ogura Mitsuhiro、Mushiake Hajime、Chiken Satomi、Nakao Naoyuki、Nambu Atsushi
    • Journal Title

      Cerebal Cortex

      Volume: 27 Issue: 12 Pages: 5716-5726

    • DOI

      10.1093/cercor/bhx234

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Striatonigral direct pathway activation is sufficient to induce repetitive behaviors2017

    • Author(s)
      Bouchekioua Youcef、Tsutsui-Kimura Iku、Sano Hiromi、Koizumi Miwako、Tanaka Kenji F.、Yoshida Keitaro、Kosaki Yutaka、Watanabe Shigeru、Mimura Masaru
    • Journal Title

      Neuroscience Research

      Volume: 17 Pages: 30454-30456

    • DOI

      10.1016/j.neures.2017.09.007

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adeno-Associated Virus-Mediated Gene Transfer into Taste Cells In Vivo.2017

    • Author(s)
      Taruno A, Kashio M, Sun H, Kobayashi K, Sano H, Nambu A, Marunaka Y.
    • Journal Title

      Chem Senses.

      Volume: 42(1) Pages: 69-78

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation.2017

    • Author(s)
      Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF.
    • Journal Title

      Nat Commun.

      Volume: 8 Issue: 1 Pages: 14304-14304

    • DOI

      10.1038/ncomms14304

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Survival of corticostriatal neurons by Rho/Rho-kinase signaling pathway.2016

    • Author(s)
      Kobayashi K, Sano H, Kato S, Kuroda K, Nakamuta S, Isa T, Nambu A, Kaibuchi K, Kobayashi K.
    • Journal Title

      Neurosci Lett.

      Volume: 630 Pages: 45-52

    • DOI

      10.1016/j.neulet.2016.07.020

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of novel dystonia musculorum mutant mice: Implications for central nervous system abnormality.2016

    • Author(s)
      Horie M, Mekada K, Sano H, Kikkawa Y, Chiken S, Someya T, Saito K, Hossain MI, Nameta M, Abe K, Sakimura K, Ono K, Nambu A, Yoshiki A, Takebayashi H.
    • Journal Title

      Neurobiol Dis.

      Volume: 96 Pages: 271-283

    • DOI

      10.1016/j.nbd.2016.09.016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Physiological and anatomical organization of cortico-striatal inputs in the basal ganglia2019

    • Author(s)
      Hiromi Sano, Kenta Kobayashi, Shigeki Kato, Satomi Chiken, Kazuto Kobayashi, Atsushi Nambu
    • Organizer
      FAOPS2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuronal responses and movements induced by concurrent activation of striatonigral and striatopallidal neurons2018

    • Author(s)
      Hiromi Sano, Kenji F Tanaka, Atsushi Nambu
    • Organizer
      FENS2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Information flow for motor control by striatal projection neurons2018

    • Author(s)
      Hiromi Sano
    • Organizer
      Stockholm-Okazaki Workshop on Multi-scale dynamice of basal ganglian in brain function and dysfunction
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 大脳皮質-線条体路の興奮誘導に対する大脳基底核の応答2018

    • Author(s)
      佐野裕美
    • Organizer
      2017年度第3回大脳基底核機能研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Physiological roles of striatal projection neurons revealed by optogenetics2018

    • Author(s)
      Hiromi Sano, Atsushi Nambu
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Cortico-striatal induced responses in the basal ganglia2017

    • Author(s)
      Hiromi Sano, Kenta Kobayashi, Shigeki Kato, Satomi Chiken, Kazuto Kobayashi, Atsushi Nambu
    • Organizer
      12th International Basal Ganglia Society Meeting
    • Place of Presentation
      メリダ(メキシコ)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 遺伝子改変マウスを用いた大脳基底核の機能と運動異常症の病態に関する研究2017

    • Author(s)
      佐野裕美
    • Organizer
      第6回生理研-霊長研-新潟脳研合同シンポジウム
    • Place of Presentation
      新潟大学(新潟県新潟市)
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Cortico-striatal induced responses in the basal ganglia2017

    • Author(s)
      Hiromi Sano, Kenta Kobayashi, Shigeki Sato, Satomi Chiken, Kazuto Kobayashi, Atsushi Nambu
    • Organizer
      International symposium, Neural Oscillation Conference 2017, Problems of Consciousness and Neuropsychiatric Disorders as Network Diseases
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] "Inhibitory center-excitatory surround" inputs from the motor cortex to the globus pallidus revealed by optogenetic stimulation2017

    • Author(s)
      Atsushi Nambu, Mitsunori Ozaki, Hiromi Sano, Shigeki Sato, Mitsuhiro Ogura, Hajime Mushiake, Satomi Chiken, Naoyuki Nakao
    • Organizer
      International symposium, Neural Oscillation Conference 2017, Problems of Consciousness and Neuropsychiatric Disorders as Network Diseases
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Responses in the basal ganglia induced by cortico-striatal neurons2017

    • Author(s)
      Hiromi Sano, Kenta Kobayashi, Shigeki Kato, Satomi Chiken, Kazuto Kobayashi, Atsushi Nambu
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Functional analysis of Rho/Rho-kinase signaling pathway in corticostriatal neuron survival using a new gene delivery system2017

    • Author(s)
      Kenta Kobayash, Hiromi Sano, Shigeki Kato, Keisuke Kuroda, Shinichi Nakamuta, Tadashi Isa, Atsushi Nambu, Kozo Kaibuchi, Kazuto Kobayashi
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] マウス神経麻痺性角膜症モデルに対する三叉神経節でのTRPV4強制発現による治療効果2017

    • Author(s)
      岡田由香、富永真琴、佐野裕美、小林憲太、南部篤、雑賀司珠也
    • Organizer
      第47回日本創傷治癒学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Cortico-striata neurons induced responses in the basal ganglia2017

    • Author(s)
      Hiromi Sano
    • Organizer
      NIPS-CIN Joint Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Concurrent activation of striatal medium spiny neurons induces involuntary movements similar to L-DOPA induced dyskinesia2017

    • Author(s)
      Hiromi Sano, Kenji F Tanaka, Atsushi Nambu
    • Organizer
      International Symposium on Adaptive Circuit Shift 2017, Behavioral adaptation and functional recovery from pathological states
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 線条体投射ニューロンによる運動調節機構の解明2016

    • Author(s)
      佐野裕美
    • Organizer
      次世代脳プロジェクト冬のシンポジウム「適応回路シフト」「記憶ダイナミズム」「マイクロ精神病態」 三領域合同若手シンポジウム
    • Place of Presentation
      一橋講堂(東京都千代田区)
    • Year and Date
      2016-12-21
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Motor control by striatal projection neurons2016

    • Author(s)
      Hiromi Sano, Kenji F Tanaka, Atsushi Nambu
    • Organizer
      第3回大脳基底核機能研究会
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2016-12-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Concurrent activation of striatonigral and striatopallidal neurons facilitates motor activity2016

    • Author(s)
      Hiromi Sano, Kenji F Tanaka, Atsushi Nambu
    • Organizer
      The 47th NIPS International Symposium "Decoding Synapses"
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Physiological Roles of Cortio-striatal Neurons in the Basal Ganglia2016

    • Author(s)
      Hiromi Sano
    • Organizer
      6th Joint CIN-NIPS Synposium
    • Place of Presentation
      チュービンゲン(ドイツ)
    • Year and Date
      2016-10-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 運動異常症モデルげっ歯類・霊長類が示す運動症状2016

    • Author(s)
      佐野裕美, 知見聡美, 長谷川拓, 堀江正男, 竹林浩秀, 吉木淳, 長谷川一子, Pullanipally Shashidharan, 南部篤
    • Organizer
      第31回日本大脳基底核研究会
    • Place of Presentation
      秋田温泉さとみ(秋田県秋田市)
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
  • [Presentation] ジストニア様症状を示すDystonia musculorumマウスにおける姿勢制御異常に関わる神経回路の解析2016

    • Author(s)
      堀江正男, 佐野裕美, 知見聡美, 小林憲太, 南部篤, 竹林浩秀
    • Organizer
      第31回日本大脳基底核研究会
    • Place of Presentation
      秋田温泉さとみ(秋田県秋田市)
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Concurrent activation of striatonigral and striatopallidal neurons facilitates movements2016

    • Author(s)
      Hiromi Sano, Kenji F Tanaka, Atsushi Nambu
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Mechanism of L-dopa induced dyskinesia: increased movement facilitation and decreased movement termination by the basal ganglia2016

    • Author(s)
      Indriani Dwi Wahyu, Hiromi Sano, Satomi Chiken, Atsushi Nambu
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Functional analysis of Rho GTPase signaling in corticostriatal neurons using a dual viral vector system2016

    • Author(s)
      小林 憲太, 佐野 裕美, 加藤 成樹, 黒田 啓介, 中牟田 信一, 伊佐 正, 南部 篤, 貝淵 弘三, 小林 和人
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Analyses of a novel Dystonin spontaneous mutant mice showing dystonic-like movements2016

    • Author(s)
      堀江 正男, 佐野 裕美, 知見 聡美, 目加田 和之, 吉木 淳, 染谷 拓郎, 小林 憲太, 南部 篤, 竹林 浩秀
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Molecular Genetic Approaches to Understanding the Physiological Roles of the Basal Ganglia2016

    • Author(s)
      Hiromi Sano
    • Organizer
      Stockholm-Okazaki Symposium ''Multi-scale Structure & Dynamics on the Basal Ganglia''
    • Place of Presentation
      ストックホルム(スウェーデン)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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