Relation between neuronal activity in the basal ganglia and voluntary movements regulated by striatal signal transduction.
Project/Area Number |
16K01968
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Brain biometrics
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Research Institution | National Institute for Physiological Sciences |
Principal Investigator |
Sano Hiromi 生理学研究所, システム脳科学研究領域, 助教 (00363755)
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Research Collaborator |
KOBAYASHI kenta
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 随意運動 / 大脳基底核 / 神経生理学 / シグナル伝達 / 線条体 / 神経活動 / ウイルスベクター / 脳・神経 / 神経科学 / 生理学 |
Outline of Final Research Achievements |
The striatum is one of the input nuclei of the basal ganglia and supposed to regulate voluntary movements. Striatal projection neurons receive information by neurotransmitters which are released from the other nuclei of the basal ganglia. After receive the neurotransmitter, signal molecules in the striatum are activated and striatal projection neurons send the information to other brain regions. To clarify the relation between activity of the signal molecule, neuronal activity of the basal ganglia and voluntary movements, we used gene transfer technique to express the dominant active form of the signal molecule in the striatum and recorded behavioral changes and neuronal activities. The dominant active form of the signal molecule in the striatum increased information flow from the striatum and facilitated voluntary movements.
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Academic Significance and Societal Importance of the Research Achievements |
大脳基底核はパーキンソン病やハンチントン舞踏病などの重度な運動障害を示す疾患と深く関わっており、線条体は創薬の標的となってきた領域である。線条体におけるシグナル伝達分子を活性化させたところ、線条体からの信号を増強し、運動を増加させたという研究成果を得たが、この結果は、このシグナル伝達分子が創薬の標的となることを示唆している。この研究成果を元に、シグナル伝達分子に作用する化合物などが合成されれば、大脳基底核に関連する運動障害を示す疾患の治療に繋がる可能性がある。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: the role of trigeminal nerve transient receptor potential vanilloid 4.2019
Author(s)
Okada Y, Sumioka T, Ichikawa K, Sano H, Nambu A, Kobayashi K, Uchida K, Suzuki Y, Tominaga M, Reinach PS, Hirai SI, Jester JV, Miyajima M, Shirai K, Iwanishi H, Kao WW, Liu CY, Saika S.
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Journal Title
Lab Invest.
Volume: 99(2)
Issue: 2
Pages: 210-230
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration.2018
Author(s)
Kaneko N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Nambu A, Kawaguchi Y, Garcia-Verdugo JM, Sawamoto K.
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Journal Title
Science Advances
Volume: 4
Issue: 12
Pages: 0618-0618
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways2018
Author(s)
Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M
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Journal Title
Neuron
Volume: 99(6)
Issue: 6
Pages: 1302-1314
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation.2017
Author(s)
Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF.
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Journal Title
Nat Commun.
Volume: 8
Issue: 1
Pages: 14304-14304
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Characterization of novel dystonia musculorum mutant mice: Implications for central nervous system abnormality.2016
Author(s)
Horie M, Mekada K, Sano H, Kikkawa Y, Chiken S, Someya T, Saito K, Hossain MI, Nameta M, Abe K, Sakimura K, Ono K, Nambu A, Yoshiki A, Takebayashi H.
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Journal Title
Neurobiol Dis.
Volume: 96
Pages: 271-283
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 運動異常症モデルげっ歯類・霊長類が示す運動症状2016
Author(s)
佐野裕美, 知見聡美, 長谷川拓, 堀江正男, 竹林浩秀, 吉木淳, 長谷川一子, Pullanipally Shashidharan, 南部篤
Organizer
第31回日本大脳基底核研究会
Place of Presentation
秋田温泉さとみ(秋田県秋田市)
Year and Date
2016-07-23
Related Report
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