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Investigation of the hippocampal memory functions using spontaneous object recognition

Research Project

Project/Area Number 16K04419
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental psychology
Research InstitutionUniversity of Tsukuba

Principal Investigator

ICHITANI Yukio  筑波大学, 人間系, 教授 (80176289)

Co-Investigator(Kenkyū-buntansha) 山田 一夫  筑波大学, 人間系, 准教授 (30282312)
Research Collaborator SUGITA manami  
OZAWA takaaki  
IWARURA etsushi  
HATAKEYAMA taichi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords記憶 / 海馬 / 自発的物体再認 / 新規蛋白質合成 / 時間順序記憶 / ラット / 自発的物体位置再認 / 蛋白質合成
Outline of Final Research Achievements

Spontaneous object recognition, animals' innate tendency to explore the novel object more than the familiar object, was used to investigate the role of hippocampus in memory function. Glutamatergic NMDA receptors in the hippocampus were suggested to be more important for retrieval of remote memory than that of recent memory, and also important for temporal order memory. Furthermore, hippocampal de novo protein synthesis was suggested to be required for the consolidation of object place memory.

Academic Significance and Societal Importance of the Research Achievements

大脳辺縁系の海馬は、ヒトを含む広範な動物の記憶・学習に不可欠の役割を果たすといわれる。本研究では、従来多くの研究で用いられてきた記憶課題とは異なり、特別の訓練や動機づけを必要とせず、動物が自発的にその場面に置かれた物体を探索するという行動を利用して記憶能力を測定することで、いくつかの新たな知見を得た。特に海馬のグルタミン酸受容体の1つであるNMDA受容体が、近時と遠隔の記憶の想起に関わるか、時間順序の記憶に関わるのか、さらに物体位置の再認では海馬の蛋白質合成が、記憶のどの段階で役割を果たすのかが示唆された。記憶研究における自発的物体再認テストの有効性が示された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (36 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (26 results) (of which Int'l Joint Research: 5 results) Remarks (3 results)

  • [Journal Article] ラットの自発的物体再認記憶に及ぼす内側前頭前野損傷の効果2019

    • Author(s)
      椙田麻菜美・山田一夫・一谷幸男
    • Journal Title

      筑波大学心理学研究

      Volume: 57 Pages: 1-9

    • NAID

      120006599961

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Social enrichment improves social recognition memory in male rats2018

    • Author(s)
      Toyoshima, M., Yamada, K., Sugita, M., & Ichitani, Y.
    • Journal Title

      Animal Cognition

      Volume: 21 Issue: 3 Pages: 345-351

    • DOI

      10.1007/s10071-018-1171-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Temporal order memory of the rat in spontaneous object recognition: Effects of number of items, exposure interval, and retention time2018

    • Author(s)
      Hatakeyama, T., Sugita, M., Yamada, K., & Ichitani, Y.
    • Journal Title

      Learning & Memory

      Volume: 25 Issue: 11 Pages: 574-579

    • DOI

      10.1101/lm.048215.118

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Involvement of hippocampal NMDA receptors in encoding and consolidation, but not retrieval, processes of spontaneous object location memory in rats2017

    • Author(s)
      Yamada, K., Arai, M., Suenaga, T. & Ichitani, Y.
    • Journal Title

      Behavioural Brain Research

      Volume: 331 Pages: 14-19

    • DOI

      10.1016/j.bbr.2017.05.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The relationship between fear extinction and resilience to drug-dependence in rats2017

    • Author(s)
      Masaharu Ueno, Kazuo Yamada, Yukio Ichitani
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 37-42

    • DOI

      10.1016/j.neures.2017.03.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differential requirements of hippocampal de novo protein and mRNA synthesis in two long term spatial memory tests: spontaneous place recognition and delay-interposed radial maze performance in rats.2017

    • Author(s)
      Ozawa, T., Yamada, K. & Ichitani, Y.
    • Journal Title

      PLOS ONE

      Volume: 12(2) Issue: 2 Pages: e0171629-e0171629

    • DOI

      10.1371/journal.pone.0171629

    • NAID

      120007134985

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hippocampal NMDA receptors are involved in rats’ spontaneous object recognition only under high memory load condition.2015

    • Author(s)
      Sugita, M., Yamada, K., Iguchi, N. & Ichitani, Y.
    • Journal Title

      Brain Research

      Volume: 1624 Pages: 370-379

    • DOI

      10.1016/j.bbr.2016.03.048

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ラットにおける恐怖条件づけの消去に及ぼすMK-801、D-cycloserine 投与の影響:ストレスレジリエンスの違いによる比較2018

    • Author(s)
      上野将玄・山田一夫・一谷幸男
    • Organizer
      第36回日本生理心理学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of dorsal hippocampal glutamate receptor blockade on rats’ temporal order memory in radial maze.2018

    • Author(s)
      Sugita, M., Takahashi, K., Yamada, K. & Ichitani, Y.
    • Organizer
      11th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Temporal order memory acquisition in rats: effect of training procedures.2018

    • Author(s)
      Sugita, M., Takahashi, K., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第78回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラットの自発的物体再認記憶に及ぼす内側前頭前野損傷の効果2018

    • Author(s)
      椙田麻菜美・山田一夫・一谷幸男
    • Organizer
      日本心理学会第82回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラットにおけるストレスレジリエンスと物体・位置再認課題の関連2018

    • Author(s)
      上野将玄・山田一夫・一谷幸男 (2018)
    • Organizer
      日本心理学会第82回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Enhanced methamphetamine-induced conditioned place preference in risk-taking rats.2018

    • Author(s)
      Takahashi, K., Ichitani, Y. & Yamada, K.
    • Organizer
      48th Annual Meeting of the Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Social enrichment enhances, while social isolation impairs, social recognition memory in male rats.2018

    • Author(s)
      Toyoshima, M., Sugita, M., Ichitani, Y. & Yamada, K.
    • Organizer
      48th Annual Meeting of the Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 背側海馬NMDA受容体拮抗薬投与がラットの自発的物体再認における時間順序記憶に及ぼす効果2018

    • Author(s)
      畠山太一・山田一夫・一谷幸男
    • Organizer
      第48回日本神経精神薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラットにおける恐怖条件づけの消去に及ぼすD-cycloserine 投与の影響:ストレスレジリエンスの違いによる比較2017

    • Author(s)
      上野将玄・山田一夫・一谷幸男
    • Organizer
      第35回日本生理心理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Involvement of the rat hippocampal NMDA and AMPA receptors in temporal order memory in radial maze2017

    • Author(s)
      Sugita, M., Yamada, K. & Ichitani, Y.
    • Organizer
      26th Annual Meeting of International Behavioral Neuroscience Society (IBNS)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 生後第2週のMK-801慢性投与は成体ラットの重篤な空間作業記憶障害を引き起こす2017

    • Author(s)
      古家宏樹・山田一夫・一谷幸男
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Atypical antipsychotic aripiprazole reduces radial-arm maze learning deficits in adult rats following chronic neonatal treatment with MK-801, an NMDA receptor antagonist2017

    • Author(s)
      Uehara, J. M., Muhamad Aiman Bin Ismail, Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第77回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 放射状迷路を用いたラットの時間的順序記憶における海馬グルタミン酸受容体の役割2017

    • Author(s)
      椙田麻菜美・山田一夫・一谷幸男
    • Organizer
      日本動物心理学会第77回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラットの放射状迷路を用いたギャンブル課題でみられるリスク選択の個体差2017

    • Author(s)
      高橋克匡・一谷幸男・山田一夫
    • Organizer
      日本動物心理学会第77回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 新生仔期MK-801の投与時期の違いがラットの空間参照記憶および作業記憶に及ぼす影響2017

    • Author(s)
      古家宏樹・山田一夫・一谷幸男
    • Organizer
      日本動物心理学会第77回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Gene expression profiling: effects of tickling on restraint stress in the adolescent rats2017

    • Author(s)
      堀 美代・大西淳之・山田一夫・坂本成子・一谷幸男・村上和雄
    • Organizer
      日本動物心理学会第77回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラットの自発的物体再認における時間順序記憶に及ぼす見本物体提示間隔の影響:見本提示項目数が2の場合2017

    • Author(s)
      畠山太一・山田一夫・一谷幸男
    • Organizer
      日本心理学会第81回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Social enrichment enhances social, but not object, memory span of rats2017

    • Author(s)
      Toyoshima, M., Sugita, M., Ichitani, Y. & Yamada, K.
    • Organizer
      47th Annual Meeting of the Society for Neuroscience
    • Related Report
      2017 Research-status Report
  • [Presentation] Spontaneous novel object recognition, object location recognition, and temporal order discrimination in rats neonatally treated chronically with MK-8012017

    • Author(s)
      Hatakeyama, T., Furuie, H., Yamada, K. & Ichitani, Y.
    • Organizer
      47th Annual Meeting of the Society for Neuroscience
    • Related Report
      2017 Research-status Report
  • [Presentation] Effects of chronic postnatal NMDA receptor blockade on latent inhibition in preadolescent rats2016

    • Author(s)
      Muhamad Aiman Bin Ismail, Niikura, R., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-11-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Effects of hippocampal AP5 treatment on relearning of radial maze task in rats2016

    • Author(s)
      Toume, S., Ishii, T., Sugita, M., Ichitani, Y. & Yamada, K.
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-11-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Individual ability for fear extinction is independent from the depressive-like behaviors in rats2016

    • Author(s)
      Ueno, M., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-11-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Effects of inter-presentation interval in the sample phase and retention interval on the temporal order memory using spontaneous object recognition paradigm in rats2016

    • Author(s)
      Hatakeyama, T., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-11-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Dorsal hippocampal NMDA and AMPA receptor blockade impairs rats’ temporal order memory in radial maze2016

    • Author(s)
      Sugita, M., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-11-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Individual ability of fear extinction predicts their resilience to drug addiction in rats2016

    • Author(s)
      Ueno, M., Yamada, K. & Ichitani, Y.
    • Organizer
      第31回国際心理学会(ICP 2016)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新生仔期MK-801慢性投与ラットのスクロース誘発性条件性場所選好2016

    • Author(s)
      古家宏樹・山田一夫・一谷幸男
    • Organizer
      第34回日本生理心理学会大会
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Research-status Report
  • [Remarks] 筑波大学大学院 人間総合科学研究科 行動神経科学分野 一谷・山田グループ

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 筑波大学人間系心理学域 研究領域とスタッフ

    • URL

      http://www.human.tsukuba.ac.jp/psyche/institute/p02.php

    • Related Report
      2018 Annual Research Report
  • [Remarks] 筑波大学大学院人間総合科学研究科 行動神経科学分野 一谷・山田グループ

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2017 Research-status Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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