| Project/Area Number |
16K04904
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nanomaterials engineering
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| Research Institution | Tokai University |
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Principal Investigator |
Kulinich Sergey 東海大学, 総合科学技術研究所, 教授 (00623092)
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| Co-Investigator(Kenkyū-buntansha) |
岡村 陽介 東海大学, 工学部, 准教授 (40365408)
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| Co-Investigator(Renkei-kenkyūsha) |
SUMIYOSHI Hideaki 東海大学, 医学部 (60343357)
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| Research Collaborator |
OKAMURA Yosuke 東海大学, 創造科学技術研究機構, 准教授 (40365408)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Laser ablation / Nanoparticles / Nanocontainers / Polymer nanosheets / Ion release / Wound dressing / Antibacterial behavior / laser ablation in liquid / nanoparticles / polymer nanosheets / biomedical material / burn wound / Burn wound healing / nanocontainers / burn wound healing / ion release / metal nanoparticles |
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| Outline of Final Research Achievements |
Thin nanosheets of biodegradable polymer incorporated with nanoparticles were produced in this study. When in contact with skin, such biologically friendly polymer materials will release proper metal ions to promote wound healing.
Using laser ablation in liquid, we first produced nanoparticles containing ions of Zn, Fe, Cu and Mg. The nanoparticles were then incorporated into polymer nanosheets thus making a dressing material for wound healing. Then, we tested how such nanosheets release metal ions in contact with physiological solution. All incorporated nanoparticles were found to release their corresponding ions within a few hours after immersion, which is very important for practical use of wound dressings. Finally, polymer dressings loaded with ZnO nanoparticles demonstrated good antibacterial action. Thus, the developed materials show promise as next-generation wound dressings which not only release proper metal ions (to promote wound healing) but also suppress bacteria.
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| Academic Significance and Societal Importance of the Research Achievements |
The obtained results are of both high practical and academic importance. They open up avenues to new-generation biodegradable biomedical materials incorporated with a range of nano-containers that can release various metal ions and drugs, which may significantly accelerate would healing.
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