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Study on low-cost micropreconcentrator using polymer microstructure for early cancer diagnosis

Research Project

Project/Area Number 16K04919
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nano/Microsystems
Research InstitutionTottori University

Principal Investigator

LEE Sang-Seok  鳥取大学, 工学研究科, 教授 (50625233)

Research Collaborator LEE jeong-o  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsマイクロ予備濃縮器 / 呼気分析 / ダブルレプリカ法 / ダブル転写法 / 1ppb / 作製プロセス / マイクロヒータ / 実験系 / マイクロ・ナノデバイス
Outline of Final Research Achievements

A double replica method was developed and applied to obtain a polymer based micropreconcentrator. We successfully fabricated the polymer microstructure micropreconcentrator based on Si mold. In the fabrication, first PDMS is poured into Si mold and we obtain female type mold made by PDMS. Then, we pour NOA63 polymer into PDMS female type mold and harden by UV irradiation. Finally, by peeling off NOA63 from PDMS female type mold, we obtain a polymer microstructure micropreconcentrator, which is the same structure to Si microstructure micropreconcentrator. In this study, we established double replica method including fabrication process conditions and obtained precise microstructure transfer results with less than 3 um in dimensions difference before and after transfer. Moreover, we also investigated applicability of microheater to shorten gas desorption time. As a result, we could obtain 300 degrees within 11-35 sec in case of 5-10 um thick Cu heater and 1V voltage apply.

Academic Significance and Societal Importance of the Research Achievements

本研究により2種類の樹脂を用いるダブルレプリカ法という新しいマイクロ流体デバイスの作製法が確立できた。本新しい作製法を用いて本研究対象であったマイクロ予備濃縮器のみならず様々なマイクロデバイス作製への応用が期待できる。また本作製法は鋳型を繰り返し利用するため資源やエネルギーの削減にもつながる。さらに安価なデバイス作製の可能性を示したため樹脂構造体を持つマイクロ予備濃縮器による呼気分析法によるがん診断法が確立できれば、安価で容易にがんの早期診断が可能になる。がんの早期診断の他にも低濃度のガスセンシングまたはろ過などへの応用も可能であるため社会で必要とする汎用性が高い研究であると考える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Presentation] ダブルレプリカ法を用いたマイクロ予備濃縮器の作製2019

    • Author(s)
      平川 裕基、Jeong-O Lee、李 相錫
    • Organizer
      第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Breath analysis based on micropreconcentrator for early cancer diagnosis2018

    • Author(s)
      Sang-Seok Lee
    • Organizer
      SPIE Photonics West 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Micropreconcentrator based cancer diagnosis2018

    • Author(s)
      Sang-Seok Lee
    • Organizer
      IEEE NEMS 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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