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Modelling on the air-water interface for advanced plasma-aided biology

Research Project

Project/Area Number 16K04998
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plasma electronics
Research InstitutionSeikei University

Principal Investigator

MURAKAMI TOMOYUKI  成蹊大学, 理工学部, 教授 (20323818)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsプラズマ化学 / モデリング / プラズマ理工学 / プラズマ / 気液境界 / バイオ応用
Outline of Final Research Achievements

Understanding the water vapor plasma is crucial for their potential applications of plasmas in biology. This study examines numerically the discharge dynamics and reacting chemistry of the gas-phase H2O plasmas. The temporal- and spatial-evolutions of species concentrations activated by a pulsed dc voltage application in a thin water vapor layer of three hundred µm are described. In an initial lower-density plasma (sub-microseconds time-scale), a broad range of neutral and ionic species are produced. In particular, ground-state atomic oxygen O(3P), atomic hydrogen H(1s), ground-state molecular oxygen O2(X), molecular hydrogen H2(X), hydroxyl radical OH(X) and cluster ions, for example H15O7+ and H15O7-. After the pulse termination, all excited and charged species immediately disappear, whereas the densities of hydrogen peroxide H2O2, hydroperoxyl HO2, ozone O3 and molecular singlet delta oxygen metastable O2(a1D) are even enhanced for sub-second time-scale.

Academic Significance and Societal Importance of the Research Achievements

空気と水、気相と液相、ミクロな化学反応とマクロな流体挙動を包括するハイブリットモデリングを確立し、トップクラスの実験研究者とのベンチマークを経て、極めて複雑な境界現象プロセス理解の深化に貢献した。本研究が貢献する分野の裾野は広く、医療・生物分野:プラズマ医療・医療機器殺菌・難分解性医療ガス処理、農業・食品分野:農作物生育促進・種子滅菌・運搬時食品鮮度維持、環境分野:水資源浄化・廃棄物処理・温暖化ガス処理、エネルギー分野:エネルギーキャリア製造・触媒支援などに大きなインパクトを与えることができ、広く科学研究費成果を実社会・産業界へ還元することができる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (45 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (30 results) (of which Int'l Joint Research: 25 results,  Invited: 5 results) Remarks (2 results)

  • [Int'l Joint Research] Queens University Belfast/University of York/University of Oxford(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Queens University Belfast/University of York/University of Oxford(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Queen's University Belfast/York University(英国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Wesleyan University(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Queen's University Belfast/York University(英国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Wesleyan University(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Numerical modelling of the effects of cold atmospheric plasma on mitochondrial redox homeostasis and energy metabolism2019

    • Author(s)
      Murakami Tomoyuki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 17138-17138

    • DOI

      10.1038/s41598-019-53219-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 放電プラズマ種の間の反応ネットワーク解析2019

    • Author(s)
      酒井道、村上朝之
    • Journal Title

      静電気学会誌

      Volume: 43 Pages: 203-208

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Cold atmospheric-pressure nitrogen plasma induces the production of reactive nitrogen species and cell death by increasing intracellular calcium in HEK293T cells2018

    • Author(s)
      Iuchi Katsuya、Morisada Yukina、Yoshino Yuri、Himuro Takahiro、Saito Yoji、Murakami Tomoyuki、Hisatomi Hisashi
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 654 Pages: 136-145

    • DOI

      10.1016/j.abb.2018.07.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design of compact dispersion interferometer with a high efficiency nonlinear crystal and a low power CO2 laser2017

    • Author(s)
      Akiyama T.、Yoshimura S.、Tomita K.、Shirai N.、Murakami T.、Urabe K.
    • Journal Title

      Journal of Instrumentation

      Volume: 12 Issue: 12 Pages: C12028-C12028

    • DOI

      10.1088/1748-0221/12/12/c12028

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crucial roles of reactive chemical species in modification of respiratory syncytial virus by nitrogen gas plasma2017

    • Author(s)
      S. Sakudo, Y. Toyokawa, Y. Imanishi and T. Murakami
    • Journal Title

      Journal: Materials Science & Engineering C

      Volume: 74 Pages: 131-136

    • DOI

      10.1016/j.msec.2017.02.007

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Diagnostics of atmospheric-pressure pulsed-dc discharge with metal and liquid anodes by multiple laser-aided methods2016

    • Author(s)
      K. Urabe, N. Shirai, K. Tomita, T. Akiyama, and T. Murakami
    • Journal Title

      Plasma Sources Sci. Technol

      Volume: 25 Issue: 4 Pages: 045004-045004

    • DOI

      10.1088/0963-0252/25/4/045004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 非平衡大気圧プラズマのシミュレーションの現状と展望/プラズマと気体の相互作用2016

    • Author(s)
      村上朝之
    • Journal Title

      プラズマ・核融合学会誌,

      Volume: 92 Pages: 688-692

    • Related Report
      2016 Research-status Report
    • Open Access / Acknowledgement Compliant
  • [Presentation] Modelling the effects of plasma on intracellular metabolism2019

    • Author(s)
      T. Murakami
    • Organizer
      72nd Gaseous Electronics Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modelling of complex chemical kinetics in atmospheric pressure plasmas2019

    • Author(s)
      T. Murakami
    • Organizer
      XXXIV ICPIG & ICRP-10
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Modeling the influence of cold atmospheric plasmas on intracellular metabolism2019

    • Author(s)
      T. Murakami
    • Organizer
      10th International Workshop on Microplasmas
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reactive nitrogen/oxygen species in cold atmospheric nitrogen-oxygen plasmas2019

    • Author(s)
      Y. Okamoto, T. Murakami
    • Organizer
      10th International Workshop on Microplasmas
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modeling of the plasma sterilization on inflammation2019

    • Author(s)
      Y. Sakai, T. Murakami
    • Organizer
      10th International Workshop on Microplasmas
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modelling on intercellular metabolism network perturbed by cold atmospheric plasmas2019

    • Author(s)
      T. Murakami
    • Organizer
      JSPF2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Extraction of primary network in humid-air plasma reaction2019

    • Author(s)
      S. Inoue, T. Murakami
    • Organizer
      JSPF2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reactive fluid simulation of a cold atmospheric plasma jet2019

    • Author(s)
      S. Arai, Y. Okamoto, S. Kawaguchi, T. Murakami
    • Organizer
      JSPF2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cold Atmospheric-pressure Nitrogen Plasma Induces Apoptotic Cell Death in HEK293T Cells2019

    • Author(s)
      K. Iuchi,Y. Morisada,Y. Yoshino,T. Himuro, Y. Saito, T. Murakami and H. Hisatomi
    • Organizer
      9th International Conference on Bioscience, Biochemistry and Bioinformatics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discharges in liquids: Experiment and Simulations of plasma kinetics2018

    • Author(s)
      B. Graham, L. Asimakoulas, T. Murakami and T. Field
    • Organizer
      71st Annual Gaseous Electronics Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Macroscopic visualization for statistics and microscopic identification of species roles in web-like plasma-enhanced chemical networks2018

    • Author(s)
      O.Sakai, Y.Mizui,T.Kojima,M.Koshiba,A.Iwai,S.Miyagi and T.Murakami
    • Organizer
      71th Annual Gaseous Electronics Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modelling biological systems perturbed by plasmas2018

    • Author(s)
      T Murakami
    • Organizer
      71th Annual Gaseous Electronics Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discharges in liquids: Experiment and Simulations of plasma kinetics2018

    • Author(s)
      L. Asimakoulas, Tom Field, T. Murakami, W. G. Graham
    • Organizer
      ESCAMPIG XXIV
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Applying network analysis to plasma data; the analysis of relations through mathematical graphs2018

    • Author(s)
      T Murakami
    • Organizer
      1st International Conference on Data-Driven Plasma Sciences
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Modelling Biological Systems for Plasma Medicine2018

    • Author(s)
      T Murakami
    • Organizer
      7th International Conference on Plasma Medicne
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gas phase discharges inside electrolyte solutions: Plasma imaging, kinetics and simulations2018

    • Author(s)
      L. Asimakoulas, T. Murakami, Tom Field, W. G. Graham
    • Organizer
      45th IOP Plasma Physics Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Systemic characterisation of pulsed laser breakdown in water and its aftermath2017

    • Author(s)
      W.G. Graham, L. Hüwel, C. Baumgart, A. Young, T. J. Morgan and T. Murakami
    • Organizer
      International Conference on Plasmas with Liquids
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2017-03-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modelling of plasma in a water vapour layer2017

    • Author(s)
      T. Murakami
    • Organizer
      10th EU-Japan Joint Symposium on Plasma Processing
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Kinetic and graph-theoretic approaches to model plasmas in liquids2017

    • Author(s)
      T. Murakami
    • Organizer
      70th Annual Gaseous Electronics Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Kinetic and graph-theoretic approaches to model the plasma-liquid interface2017

    • Author(s)
      T. Murakami
    • Organizer
      9th International Workshop on Microplasmas
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Modelling on plasma production and chemistry in a water vapour layer2017

    • Author(s)
      T. Murakmai
    • Organizer
      44th EPS Conference on Plasma Physics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラズマ液体境界のモデリング2017

    • Author(s)
      村上朝之
    • Organizer
      PLASMA2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Reacting chemistry at the air-water interface2016

    • Author(s)
      T. Murakami
    • Organizer
      69th Annual Gaseous Electronics Conference
    • Place of Presentation
      Bochum, Germany
    • Year and Date
      2016-10-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simulation of discharge production in a water vapour layer on an electrode2016

    • Author(s)
      M. L. Karim, B. Evans, L. Asimakoulas, K. R. Stalder, T.A. Field and W. G. Graham and T. Murakami
    • Organizer
      69th Annual Gaseous Electronics Conference
    • Place of Presentation
      Bochum, Germany
    • Year and Date
      2016-10-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Network structural analysis using directed graph for chemical reaction analysis in weakly-ionized plasmas2016

    • Author(s)
      K. Nobuto, Y. Mizui, S. Miyagi, O. Sakai and T. Murakami
    • Organizer
      69th Annual Gaseous Electronics Conference
    • Place of Presentation
      Bochum, Germany
    • Year and Date
      2016-10-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modelling of Plasma Interaction with Gas-Liquid Interface2016

    • Author(s)
      T. Murakami, T. J. Morgan, L. Hüwel and W. G. Graham
    • Organizer
      6th International Conference on Plasma Medicine
    • Place of Presentation
      Bratislava, Slovakia
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 8.Surface, Liquid and Vapour Phenomena in Electrical Discharge Formation in Saline Solutions2016

    • Author(s)
      W. G. Graham and T. Murakami
    • Organizer
      43rd IOP Plasma Physics Conference
    • Place of Presentation
      Isle of Skye、UK
    • Year and Date
      2016-05-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Laser Plasma Effects in Water2016

    • Author(s)
      T. J. Morgan, L. Hüwel, W. G. Graham and T. Murakami
    • Organizer
      43rd IOP Plasma Physics Conference
    • Place of Presentation
      Isle of Skye、UK
    • Year and Date
      2016-05-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modeling of atmospheric pressure plasmas reacting with air and water2016

    • Author(s)
      T. Murakami
    • Organizer
      13th Asia-Pacific Conference on Plasma Science and Technology
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Atmospheric-pressure plasma chemistry, Fundamental and application2016

    • Author(s)
      T. Murakami
    • Organizer
      QUB Workshop on Physics
    • Place of Presentation
      Belfast, UK
    • Year and Date
      2016-04-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] プラズマエネルギーデザイン研究室

    • URL

      http://www.sd.seikei.ac.jp/lab/pedl/index.html

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Remarks] 成蹊大学理工学部システムデザイン学科プラズマエネルギーデザイン研究室

    • URL

      http://www.sd.seikei.ac.jp/lab/pedl/

    • Related Report
      2017 Research-status Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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