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Medical radioisotope 99Mo produced by using accelerator neutrons

Research Project

Project/Area Number 16K05383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Particle/Nuclear/Cosmic ray/Astro physics
Research InstitutionOsaka University (2019)
National Institutes for Quantum and Radiological Science and Technology (2016-2018)

Principal Investigator

NAGAI YASUKIMe  大阪大学, 核物理研究センター, 協同研究員 (80028240)

Co-Investigator(Kenkyū-buntansha) 藤田 博喜  国立研究開発法人日本原子力研究開発機構, 核燃料・バックエンド研究開発部門 核燃料サイクル工学研究所 放射線管理部, 研究副主幹 (20446446)
塚田 和明  国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 原子力科学研究所 先端基礎研究センター, 研究主席 (30343916)
橋本 和幸  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 上席研究員(定常) (80414530)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords核医学診断 / 放射性医薬品 / テクネチウム99m / モリブデン99 / 加速器中性子 / 比放射能 / 熱分離 / ミルキング / モリブデナム99 / 加速器 / 高速中性子 / 放射性同位体 / 画像 / 濃縮試料 / 熱分離法 / 原子核物理実験 / 放射線 / 核医学 / 薬学
Outline of Final Research Achievements

We found anomalously large yields of several radioisotopes such as 64Cu and 67Ga when a 68ZnO sample which was covered with polyethylene blocks was irradiated with accelerator neutrons. We believe that this finding is quite important for producing radioisotopes in large quantity with accelerator neutrons. It should be mentioned that in the present experimental condition we could produce simultaneously several radioisotopes which are normally generated by proton-induced reaction.

Academic Significance and Societal Importance of the Research Achievements

放射性(RI)医薬品を用い様々な病気の早期診断・治療は重要。99mTcは輸入した99Moから医薬品化し我が国で毎日3000人の診断を実施。99Moの供給不足が頻発、我々は99Mo国産化に向けし加速器製中性子を用いる99Moを製造する方法を提案。本o製造法は、不要RIの生成量が微量、1台の加速器で日本の99Mo需要の相当量を供給、治療用RIも製造可能。我々は99Moから高品質の99mTc分離に成功し、実用化に向け大きな成果を得た。また加速器中性子を試料ごと遮蔽体内に閉じ込めた場合、遮蔽体が無い時には製造されないRIが製造される新現象を発見し医療用RI製造及び実用上重要な結果を得た。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (21 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (9 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Anomalous Radioisotope Production for 68ZnO Using Polyethylene by Accelerator Neutrons2020

    • Author(s)
      Tsukada Kazuaki、Nagai Yasuki、Hashimoto Shintaro、Minato Futoshi、Kawabata Masako、Hatsukawa Yuichi、Hashimoto Kazuyuki、Watanabe Satoshi、Saeki Hideya、Motoishi Shoji
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 89 Issue: 3 Pages: 034201-034201

    • DOI

      10.7566/jpsj.89.034201

    • NAID

      40022185676

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recommended nuclear data for medical radioisotope production: diagnostic gamma emitters2019

    • Author(s)
      Tarkanyi F. T.、Ignatyuk A. V.、Hermanne A.、Capote R.、Carlson B. V.、Engle J. W.、Kellett M. A.、Kibedi T.、Kim G. N.、Kondev F. G.、Hussain M.、Lebeda O.、Luca A.、Nagai Y.、Naik H.、Nichols A. L.、Nortier F. M.、Suryanarayana S. V.、Takacs S.、Verpelli M.
    • Journal Title

      Journal of Radioanalytical and Nuclear Chemistry

      Volume: 319 Issue: 2 Pages: 487-531

    • DOI

      10.1007/s10967-018-6142-4

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Recommended nuclear data for medical radioisotope production: diagnostic positron emitters2019

    • Author(s)
      Tarkanyi F. T.、Ignatyuk A. V.、Hermanne A.、Capote R.、Carlson B. V.、Engle J. W.、Kellett M. A.、Kibedi T.、Kim G. N.、Kondev F. G.、Hussain M.、Lebeda O.、Luca A.、Nagai Y.、Naik H.、Nichols A. L.、Nortier F. M.、Suryanarayana S. V.、Takacs S.、Verpelli M.
    • Journal Title

      Journal of Radioanalytical and Nuclear Chemistry

      Volume: 319 Issue: 2 Pages: 533-666

    • DOI

      10.1007/s10967-018-6380-5

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reference Cross Sections for Charged-particle Monitor Reactions2019

    • Author(s)
      Hermanne A., V. Ignatyuk A., Capote R., V. Carlson B., W. Engle J., A. Kellett M., T. Kib´edi, Kim G., G. Kondev F., Hussain M., Lebeda O., Luca A., 永井 泰樹 , Naik H., L. Nichols A., M. Nortier F., V. Suryanarayana S. , S.Tak´acs, F. T. T´ark´anyi, Verpelli M.
    • Journal Title

      Nuclear Data Sheets

      Volume: 148 Pages: 338-382

    • DOI

      10.1016/j.nds.2018.02.009

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 塚田 和明 , 永井 泰樹 , 橋本 和幸 , 川端 方子 , 湊 太志 , 佐伯 秀也 , 本石 章司 , 伊藤 正俊2018

    • Author(s)
      99Mo Yield Using Large Sample Mass of MoO3 for Sustainable Production of 99Mo
    • Journal Title

      Journal of the Physical Society of Japan (JPSJ)

      Volume: 87 Issue: 4 Pages: 043201-043201

    • DOI

      10.7566/jpsj.87.043201

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measurement and Estimation of the 99Mo Production Yield by 100Mo(n,2n)99Mo2017

    • Author(s)
      Futoshi Minato, Kazuaki Tsukada, Nozomi Sato, Satoshi Watanabe, Hideya Saeki
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 86, 114803 Issue: 11 Pages: 114803-114803

    • DOI

      10.7566/jpsj.86.114803

    • NAID

      210000134596

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quality of 99mTcO4- from 99Mo Produced by 100Mo(n,2n)99Mo2017

    • Author(s)
      Yasuki Nagai, Yuto Nakahara, Masako Kawabata, Yuichi Hatsukawa, Kazuyuki Hashimoto
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 86 Issue: 5 Pages: 053202-053202

    • DOI

      10.7566/jpsj.86.053202

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recovery Efficiency of Enriched 100MoO3 Irradiated by Accelerator Neutrons2017

    • Author(s)
      Masako Kawabata, Shoji Motoishi, Hideya Saeki, Kazuyuki Hashimoto, and Yasuki Nagai
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 86 Issue: 5 Pages: 053201-053201

    • DOI

      10.7566/jpsj.86.053201

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of 67Cu Produced by 68Zn(n,n'p+d)67Cu to Biodistribution Study in Tumor-Bearing Mice2017

    • Author(s)
      Y. Sugo, K. Hashimoto, M. Kawabata, H. Saeki, S. Sato, K. Tsukada, and Y. Nagai
    • Journal Title

      J. Phys. Soc. Jpn.

      Volume: 86 Issue: 2 Pages: 023201-023201

    • DOI

      10.7566/jpsj.86.023201

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Productions of 99Mo and 67Cu using accelerator neutrons for domestic use2018

    • Author(s)
      永井 泰樹 , 橋本和幸 , 川端方子 , 塚田和明 , 初川雄一 , 須郷由美 , 佐伯秀也 , 本石章司 , 湊太志
    • Organizer
      ヨーロッパ核医学会2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Production of 99Mo/99mTc and 67Cu for medical use by accelerator neutrons2018

    • Author(s)
      永井泰樹
    • Organizer
      セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Quality control tests of 99Mo/99mTc and 67Cu produced using accelerator neutrons2018

    • Author(s)
      永井泰樹
    • Organizer
      15th Varenna Conference on Nuclear Reaction Mechanisms
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Production of 99Mo/99mTc and 67Cu by Accelerator Neutrons from C(d,n)2018

    • Author(s)
      Yasuki Nagai
    • Organizer
      The 7th Yamada Workshop on RI Science Evolution
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 加速器を利用した放射性医薬品製造の進歩と未来2016

    • Author(s)
      永井泰樹
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 日本におけるモリブデン/テクネチウムの安定供給の現状2016

    • Author(s)
      永井泰樹
    • Organizer
      第44回日本放射線技術学会秋季学術集会
    • Place of Presentation
      さいたま市
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 99mTc derived from 99Mo produced by acceleartor neutrons2016

    • Author(s)
      永井泰樹
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging 2016
    • Place of Presentation
      サンデイエゴ、アメリカ
    • Year and Date
      2016-06-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] FBNews2019

    • Author(s)
      非侵襲医療に向けた革新的アイソトープ製造法
    • Total Pages
      5
    • Publisher
      株式会社千代田テクノル
    • Related Report
      2018 Research-status Report
  • [Book] 核データニュース2019

    • Author(s)
      医療用アイソトープ製造と非侵襲個別化医療
    • Total Pages
      14
    • Publisher
      日本原子力学会
    • Related Report
      2018 Research-status Report
  • [Book] Isotope News2017

    • Author(s)
      永井泰樹、塚田和明
    • Total Pages
      5
    • Publisher
      日本アイソトープ協会
    • Related Report
      2017 Research-status Report
  • [Book] 市民のためのがん治療の会2017

    • Author(s)
      川端方子、永井泰樹
    • Total Pages
      6
    • Publisher
      市民のためのがん治療の会
    • Related Report
      2017 Research-status Report
  • [Remarks] プロジェクト「加速器中性子利用RI生成研究」

    • URL

      https://www.qst.go.jp/site/acc-neutron/

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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