| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
This research focused on the role of saccharide chains expressed on human embrionic stem cells on their interactions. Dependence of equilibrium inter-membrane distance on the osmotic pressure and calcium ion concentration, and mechanical property of lipid membrane on the molecular structure of saccharide chains and molar ratio were systematically revealed. Adhesion area of human iPS cells on supported lipid membranes functionalized with various kinds of saccharide chains were also measured. The methodology developed in this research was also applied to other systems, resulted in such as revealing long-range lateral correlation of self-assambled domains of fluorocarbon-hydrocarbon molecules, quantification of the interfacial interaction potential between zwitterionic polymer brush and model cells, and the development of bio-marker for quality control and prognosis of human corneal endothelial cells/tissues.
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