| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Stereodivergent synthesis was proposed and successful by the metal promoted reactions with cyclic azomethine ylides from 2-pyrroline ester and 4-oxazoline esters.
The reaction of 4-oxazoline esters with nitroalkenes followed by reduction, the reaction of 2-pyrroline esters with enones followed by reduction afforded a single stereoisomer of the spirooxazoline lactam and the fused bicyclic pyrolizidines stereo- and stereodiversely, respectively. These molecules have potent biologically and pharmaceutically important structures, so the present study will be leading to drug discovery.
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