| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Garactose oxidase (GO) is a single copper oxidase, which catalyzes oxidation of a primary alcohol to the corresponding aldehyde. The active form of GO is well-known to be a Cu(II)-phenoxyl radical, which can act as two electron oxidant for the primary alcohol oxidation to form a Cu(I)-phenol species. Reaction of the Cu(I)-phenol species with an oxygen molecule to reproduce the Cu(II)-phenoxyl radical, and therefore GO is possible to be fuctionalization as a catalyst. The purpose of this study was such the formation of the phenoxyl radical metal complexes by air oxidation. We have been successful to find out formation of the Cu(II)-phenoxyl radical complex by air-oxidation from the various investigation.
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