| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Radical SAM enzymes, which play important roles in transformation of inactive C-H bonds, utilize a 4Fe-4S cluster center to generate the active radical agent. Artificial reaction sites based on the same cubic skeleton composed of ruthenium in place of iron have been developed in this project with the aim of use in generation of radical species via reductive bond cleavage and in electron transfer catalysis. By combination of a tetranuclear ruthenium cluster with various supporting ligands, a series of cubane-type cluster derivatives having one to four coordinatively active ruthenium sites have been synthesized. The isoelectronic cluster whose three metal sites are substituted by iridium atoms provided the rest ruthenium center for the binding site of small molecules and showed high catalytic activity in electron transfer reduction.
|
