| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We have examined methods for efficiently generating chiral silver(I) methoxide with high purity as well as methods for preparing chiral silver(I) enolates from the methoxide. As a result, we have found that the Hunig base or triethylamine is effective as an additive for the purpose and desired chiral silver(I) methoxide and the corresponding chiral silver(I) enolates can be prepared with high purities. When asymmetric aldol reaction of isatin derivatives via a chiral silver(I) enolate has been performed using this method, a high level of asymmetric induction has been observed for the aldol products. Asymmetric nitrosoaldol reaction, asymmetric allylation of aldehydes, and asymmetric allenylation/propargylation of aldehydes have been also attained by applying the present catalytic method of generating chiral silver(I) enolates to various electrophiles.
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