| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
It is known that the boryl group can be converted into various functional groups. If para-selective C-H bond direct borylation is possible, various functionalization of the para-positions of the benzene rings can be realized. The Iridium-catalyzed C-H borylation reaction proceeds at the meta- and para-positions of monosubstituted benzenes, and regioselectivity has not been controlled. In this study, we developed a novel catalytic system for para-selective C-H borylation to synthesize molecules with various functions and properties. In addition, this reaction was used to construct libraries for functional organic molecules and complex natural organic compounds via borylation at the late-stage of synthesis.
|
