| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this research project, transition metal catalyzed sp3-carbon-hydrogen bond functionalization of carbonyl compounds and amine compounds, which are otherwise difficult to activate and functionalize previously, is studied in order to improve the practicality and efficiency of the C-H bond functionalization reaction. As the result, palladium-catalyzed carbon monoxide insertion reaction into the C-H bond at the β-position of N-carboxyl amine to furnish β-lactam is found. The reaction undergoes through the cleavages of nitrogen-oxygen and carbon-hydrogen bond in the molecule, which is scientifically interesting and mechanistically unprecedent.
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