| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we developed an efficient method of organic transformation process by using niobium complexes as highly reactive and structural stable catalysts in organic transformations. For example, we achieved a one-step reaction of simple alkyne with nitriles to afford pyrimidine as a heterocyclic compound in the presence of niobium complex catalyst.In this reaction, the addition of iron chloride efficiently assisted the niobium catalyzed reaction. Moreover, we developed in-situ generated niobium-carbene complex serves as an efficient catalyst for highly active olefin ring-closing metathesis reaction. Thus, we have found that niobium complexes can be employed as effective catalytic tools in the development of highly challenging and practical organic transformations reactions with high social needs.
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