| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, in order to develop new high-intensity red fluorescence analysis reagents using fluorescence resonance energy transfer (FRET), we synthesized several BODIPY derivatives linked to tryptanthrin derivatives with a spacer. The BODIPY derivatives are fluorescent dyes having a small change in absorption and fluorescence wavelength depending on the solvent, and the tryptanthrin derivatives are red fluorescent dyes exhibiting solvatochromism in response to the polarity of the solvent.
As a result, it was found that detection of Cu2+, Fe3+, and Al3+ was possible by changing from FRET-on to -FRET-off.
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