| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Due to the biological importance of α-amino acids and their derivatives, the development of novel colorimetric probes for these molecules has been an active research area in recent years. In this study, the surface-enhanced photochromic phenomena by various α-amino acids adsorbed on molybdenum(VI) oxide (MoO3) nanoparticles in the aqueous system have been investigated by means of UV-vis absorption spectrometry. No derivatization of α-amino acids is required, and eventually high-accuracy determination is obtained from the UV-induced MoO3 photochromic coloration. During UV irradiation, the detection process could be visually observed by naked eyes. A simple and unique approach to explore sensitive "label-free" colorimetric sensing toward α-amino acids is proposed. Additionally, human serum albumin was added to tungsten(VI) oxide (WO3) and/or MoO3 nanoparticle aqueous solution to probe the photochromic properties.
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