| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Recently, the interaction of Plasmodium falciparum with human plasminogen (hPlg) represents a mechanism to invade host-cells, such as human erythrocytes and mosquito midgut, by capturing surface-associated proteolytic activity in the infected host. hPlg binds to surface displayed P.f. enolase (PfEno) and is subsequently activated to the serine protease plasmin (hPln) by host-derived tissue hPlg activator or urokinase. In this study, we analyzed a Plg-activation mechnism of PfEno by using synthetic peptide libraries.
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