| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We synthesized water-soluble P- and Sb-porphyrin complexes containing axial amphiphilic ligands, such as alkyl pyridimium moieties, in order to develop a photosensitizer for the photosterilization. The photobactericidal effects of the complexes were evaluated using nonpathogenic model cells, such as Saccharomyces cerevisiae and Escherichia coli. Optimization of the axial ligand by the introduction of appropriate alkyl groups improved the photobactericidal activities. Moreover, we succeeded in conversion of the complexes to the hydroporphyrin complexes with visible light absorption band at the longer wavelength in the phototherapeutic window. These complexes were exhibited to be promising as the photosensitizer for the photosterilization.
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