| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Glycosaminoglycans (GAGs) are one of the most complex molecule among glycans and play a role in a variety of biological event such as cell development, proliferation, and canceration. In this research, aiming functional analysis and medical application of GAGs, we examined systematic synthesis of partial structures containing chondroitin sulfate (CS) and dermatan sulfate (DS). In addition we evaluated their binding properties to GAG-binding proteins by surface plasmon resonance (SPR) imaging sensor using array-type sugar chip on which synthesied CS/DS partial structure library is immobilised. Furthermore, we analysed the binding interation of CD/DS partial structure and GAG-binding proteins by molecular modeling.
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