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Deveriopment of mrdical adhesive based on chitin and its nanofiber

Research Project

Project/Area Number 16K05915
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Polymer/Textile materials
Research InstitutionTottori University

Principal Investigator

SAIMOTO Hiroyuki  鳥取大学, 工学研究科, 教授 (20186977)

Research Collaborator AZUMA Kazuo  
OKAMOTO Yoshiharu  
MORIMOTO Minoru  
IFUKU Shinsuke  
OSAKI Tomohiro  
IZAWA Hironori  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsキチン / キトサン / ナノファイバー / 生体接着剤 / 生体シーリング材 / 生体親和性 / 生体内消化性 / キチン質複合材料 / ナノ繊維 / 光重合開始剤 / オゾン / バイオマス / 高分子構造・物性
Outline of Final Research Achievements

1.Novel biological adhesives made from chitin methacrylate derivatives and various chitin nanofibers were prepared and evalated for their adhesive properties and biocompatibility. Quick adhesion and introduction of imflammatory cells migration were observed. These findings mean that the composites prepared in this study are promising materials as new biological adhesives.
2. As polimerization initiater, we found that ozone/glycerol solution was very useful.
3. In this study, we used bioconpatible materials such as chitins and glycerol.

Academic Significance and Societal Importance of the Research Achievements

1.怪我や外科手術においては、傷口の迅速かつ安全な接着またはシーリングが求められている。また、臓器など、元々、縫合困難な部位もある。本研究では、生体親和性と生体内消化性を併せ持つ「キチン質(カニ殻由来)」を活用し、秒単位の迅速な接着と、回復後には生分解されるという二つの長所を併せ持つ方法を開発した。さらに、グリセロールが生体適合性であることから、重合開始剤としてオゾン/グリセロール溶液を用いた試験を、世界で初めて達成した。
牛・豚由来等の組織や血液製剤等を用いないので、狂牛病やエイズなどの感染の危険が無い。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2016

All Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 3 results) Presentation (1 results) Book (2 results)

  • [Journal Article] Chitin biological extraction from shrimp wastes and its fibrillation for elastic nanofiber sheets preparation2019

    • Author(s)
      Aranday-Garcia Rut、Saimoto Hiroyuki、Shirai Keiko、Ifuku Shinsuke
    • Journal Title

      Carbohydrate Polymers

      Volume: 213 Pages: 112-120

    • DOI

      10.1016/j.carbpol.2019.02.083

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hair growth-promoting activities of chitosan and surface-deacetylated chitin nanofibers2019

    • Author(s)
      Azuma Kazuo、Koizumi Ryo、Izawa Hironori、Morimoto Minoru、Saimoto Hiroyuki、Osaki Tomohiro、Ito Norihiko、Yamashita Masamichi、Tsuka Takeshi、Imagawa Tomohiro、Okamoto Yoshiharu、Inoue Tadashi、Ifuku Shinsuke
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 126 Pages: 11-17

    • DOI

      10.1016/j.ijbiomac.2018.12.135

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guanidinylated chitosan inspired by arginine-rich cell-penetrating peptides2019

    • Author(s)
      Izawa Hironori、Kinai Mizuki、Ifuku Shinsuke、Morimoto Minoru、Saimoto Hiroyuki
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 125 Pages: 901-905

    • DOI

      10.1016/j.ijbiomac.2018.12.138

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discrimination of anionic polysaccharides via monomer-excimer switching and photo-induced colorimetric reaction of 1-methyl-3-(N-(1,8-naphthalimidyl)ethyl)imidazolium2018

    • Author(s)
      H. Izawa,* M. Wada, S. Nishino, M. Sumita, T. Fujita, K. Morihashi, S. Ifuku, M. Morimoto, H. Saimoto
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 91 Issue: 8 Pages: 1220-1225

    • DOI

      10.1246/bcsj.20180128

    • NAID

      130007435608

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of Bio-Based Wrinkled Surfaces as Cell Culture Scaffolds2018

    • Author(s)
      Izawa Hironori, Okuda Noriko, Yonemura Tomoe, Kuroda Kohei, Ochi Kosuke, Ifuku Shinsuke, Morimoto Minoru, Saimoto Hiroyuki, Noda Mayuko, Azuma Kazuo, Ito Norihiko
    • Journal Title

      Colloids and Interfaces

      Volume: 2 Issue: 2 Pages: 15-25

    • DOI

      10.3390/colloids2020015

    • NAID

      120006709735

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions2018

    • Author(s)
      Miyazaki Yukiko、Inaoka Daniel K.、Shiba Tomoo、Saimoto Hiroyuki、Sakura Takaya、Amalia Eri、Kido Yasutoshi、Sakai Chika、Nakamura Mari、Moore Anthony L.、Harada Shigeharu、Kita Kiyoshi
    • Journal Title

      Frontiers in Pharmacology

      Volume: 9 Pages: 997-997

    • DOI

      10.3389/fphar.2018.00997

    • NAID

      120006987943

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bio-based wrinkled surfaces induced by wood mimetic skins upon drying effect of mechanical properties on wrinkled morphology2016

    • Author(s)
      Hironori Izawa, Noriko Okuda, Arisu Moriyama, Yuka Miyazaki, Shinsuke Ifuku, Minoru Morimoto, Hiroyuki Saimoto
    • Journal Title

      Lungmuir

      Volume: 32 Issue: 48 Pages: 12799-12804

    • DOI

      10.1021/acs.langmuir.6b03330

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protein/CaCO3/chitin nanofiber complex prepared from crab shells by simple mechanical treatment and its effect on plant growth2016

    • Author(s)
      Yihun Fantahun Aklog, Mayumi Egusa, Hironori Kaminaka, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Journal Title

      International Journal of Molecular Science

      Volume: 17 Issue: 10 Pages: 1600-1600

    • DOI

      10.3390/ijms17101600

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preparation of chitin nanofibers by surface esterification of chitin with maleic anhydride and mechanical treatment2016

    • Author(s)
      Yihun Fantahun Aklog, Tomone Nagae, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Journal Title

      Carbohydrate Polymers

      Volume: 153 Pages: 55-59

    • DOI

      10.1016/j.carbpol.2016.07.060

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chitin nanofibrils suppress skin inflammation in atopic dermatitis-like skin lesions in NC/Nga mice2016

    • Author(s)
      Ryotaro Izumi, Kazuo Azuma, Hironori Izawa, Minoru Morimoto, Masaaki, Nagashima, Tomohiro Osaki, Takeshi Tsuka, Tomohiro Imagawa, Norihiko Ito, Yoshiharu Okamoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Journal Title

      Carbohydrate Polymers

      Volume: 146 Pages: 320-327

    • DOI

      10.1016/j.carbpol.2016.03.068

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prepared by Horseradish Peroxidase-catalyed Polymerization2016

    • Author(s)
      H. Izawa, Y. Miyazaki, S. Ifuku, M. Morimoto, H. Saimoto
    • Journal Title

      Chem. Lett.

      Volume: 45 Pages: 631-633

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 経口摂取によるキチン質の抗炎症効果2016

    • Author(s)
      東 和生,伊福伸介,斎本博之,岡本芳晴
    • Organizer
      第30回日本キチン・キトサン学会大会
    • Place of Presentation
      埼玉県川越市ウェスタ川越
    • Year and Date
      2016-08-18
    • Related Report
      2016 Research-status Report
  • [Book] キチン・キトサンの最新化学技術-機能性ファイバーと先端医療材料-2016

    • Author(s)
      東 和生, 大崎智弘, 岡本芳晴, 斎本博之, 伊福伸介,  分担執筆
    • Total Pages
      14
    • Publisher
      技報堂出版
    • Related Report
      2016 Research-status Report
  • [Book] バイオマス由来の高機能材料2016

    • Author(s)
      森本 稔, 斎本博之,  分担執筆
    • Total Pages
      8
    • Publisher
      株式会社エヌ・ティー・エス
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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