| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In this study, the synthesis and organic modified (polyethylene glycol: PEG) of the anticancer agent (5-fluorouracil: 5-FU or methotrexate: MTX)/LDH by the rapid mixing and coprecipitation methods for the application of layered double hydroxide (LDH) were investigated. In order to promote the cellular uptake of the anticancer agent, the particle size control of the anticancer agent/LDH and the cytotoxicity assay of the anticancer agent/LDH were also studied.
The results of XRD, FT-IR and XPS suggested that the anticancer agent/LDH was obtained by both methods. The result of DLS indicated that the average particle size of the anticancer agent/LDH was ca. 200 nm. SEM image of the anticancer drug/LDH also revealed that the anticancer agent/LDH particle formed the large size aggregation; however, the primary particle size was 150-200 nm. The cytotoxicity of the anticancer agent/LDH was found to be about 7 times higher than that of 5-FU against HeLa cells.
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