| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To investigate the vibration response, excitation experiments were conducted for an osteoblastic cell or a cancer cell. Their natural frequency and mode of vibration were not clearly measured in the range from 12.5 to 100 Hz and from 0.25 to 1 G. It indicates that the improvement of spatial resolution for measurement may be required. To promote both cell proliferation and cell differentiation, excitation experiments were conducted for osteoblastic cells applying the mechanical vibration superposing 0.5 G and 12.5 Hz vibration and 0.5 G and 50 Hz vibration. Both the cell proliferation and the cell differentiation were promoted and the type of cells can be modelled as a linear system. The effect of mechanical vibration on chondrocytes using plane culture without special scaffolds were investigated. The thickness of tissue generated by chondrocytes under the 0.5 G and 12.5 Hz mechanical vibration were approximately 1.5 times as thick as that without vibration.
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