| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
A new class of nanoparticle (NP) was fabricated by cross-linking silsesquioxane units via disulfide bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin (DOX)-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells were examined.
The DOX-loaded NPs released DOX within the intercellular pool after internalization by HeLa cells. As the DOX-loaded NPs enabled stimulus-responsive rapid release of the loaded drug and self-decomposition to clusters, they could be useful as a new silica-based nanocarrier for cancer therapy.
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