| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Forgotten memories may occasionally be recollected spontaneously. Even after the memories fade over time, the forgotten memories may persist latently in the brain. However, clinically applicable method that promotes the retrieval of forgotten long-term memories has not yet been established.
In the current study, we examined whether activation of brain histamine system promote the retrieval of a forgotten long-term object memory in mice. We employed the novel object recognition task, in which the test session mice were presented with a novel object and a familiar object that was presented during the training session. One week after training, the mice were unable to discriminate the novel object from the familiar one. However, activation of brain histamine system before the test session enhanced discrimination score. The results indicate that activation of brain histamine system promotes retrieval of forgotten object memories.
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