• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Unravelling Mechanisms Underlying Termination of Neuronal Migration

Research Project

Project/Area Number 16K07010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute of Genetics

Principal Investigator

Zhu Yan  国立遺伝学研究所, 遺伝形質研究系, 助教 (50464235)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsneuronal migration / termination / RNA-seq / bHLH / contactin-2 / chain migration / protein processing / Robo3 / tangential migration / migration termination / Contactin-2 / Secretase / Chain migration / termination of migration / Tag-1 / Bace1 / RNA sequencing / transcriptome profile / degradation / leading processes
Outline of Final Research Achievements

One of the challenges to generate a functional brain is to correctly position different types of neurons into their proper final destinations. This process takes place at the termination phase of neuronal migration, but its underlying mechanisms are still poorly understood. This research aims to uncover these mechanisms using the mouse hindbrain as a model system. We have taken two different approaches, an unbiased transcriptome profiling approach using the recently developed genomic technology RNA-seq, and a candidate gene approach focusing on molecules that are regulated at post-transcriptional level. From these approaches, we have successfully identified a pair of transcription factors that are involved in migration and termination of migration, a receptor/ligand system that fine-tune the final location of neurons, and a post-translational regulation of a cell adhesion molecule by proteolysis during transition from migration to termination.

Academic Significance and Societal Importance of the Research Achievements

本研究の網羅的RNA-seqで得られた情報は、本研究の深化のみならず、将来的に様々な発見につながる波及効果をもたらすと期待される。神経細胞の位置異常は、神経発達障害における主要な原因である。実際、本研究で解析したいくつかの分子については、神経発達障害との関連が示唆されている。したがって、本研究はこれらの病気や病態の理解にも貢献すると考えられる。さらに、神経細胞移動の方向づけや、目的地で移動を停止する機構を理解することは、将来的に神経発達障害や神経障害の治療法を考える上でも有益な知見となるはずである。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] From migration to settlement: the pathways, migration modes and dynamics of neurons in the developing brain2016

    • Author(s)
      Yumiko Hatanaka, Yan Zhu, Makio Torigoe, Yoshiaki Kita, Fujio Murakami
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 92 Issue: 1 Pages: 1-19

    • DOI

      10.2183/pjab.92.1

    • NAID

      130005118553

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Contactin-2 (Tag-1) and its processing: in neuronal migration and the making of pontine nuclei2020

    • Author(s)
      Zhu Y, Masuda A, Hirata T
    • Organizer
      International Symposium on Neural Develpoment, Regeneration & Diseases
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms underlying termination of tangential neuronal migration investigated by a RNA-sesq based approach2019

    • Author(s)
      Masuda A, Nakaoka H, Toyoda A, Hirata T, Zhu Y
    • Organizer
      Spring Meeting of the Japanese Society of Genetics
    • Related Report
      2019 Annual Research Report
  • [Presentation] Mechanisms underlying termination of tangential neuronal migration investigated by a RNA-seq based approach2019

    • Author(s)
      Masuda A, Nakaoka H, Toyoda A, Hirata T, Zhu Y
    • Organizer
      Spring Meeting of the Japanese Society of genetics, Mishima
    • Related Report
      2018 Research-status Report
  • [Presentation] Mechanisms underlying termination of tangential neuronal migration investigated by a RNA-seq based approach2018

    • Author(s)
      Masuda A, Nakaoka H, Toyoda A, Hirata T, Zhu Y
    • Organizer
      Biennial Meeting of the International Society for Developmental Neuroscience, Nara
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanisms underlying termination of tangential neuronal migration investigated by a RNA-seq based approach2018

    • Author(s)
      Masuda A, Nakaoka H, Toyoda A, Hirata T, Zhu Y
    • Organizer
      Annual Meeting of the Japanese Society of Neurosience, Kobe
    • Related Report
      2018 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi