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How do the basal ganglia and cerebellum control voluntary movements?

Research Project

Project/Area Number 16K07014
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

Chiken Satomi  生理学研究所, システム脳科学研究領域, 助教 (30396262)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大脳基底核 / 小脳 / 視床 / サル / 運動制御 / 光遺伝学 / 神経活動記録 / マカクサル / 神経活動 / 神経科学
Outline of Final Research Achievements

To understand how the basal ganglia and cerebellum control voluntary movements, we recorded thalamocortical activity during performance of a hand reaching task in macaque monkeys. Basal ganglia-thalamic inputs and cerebello-thalamic inputs were selectively blocked or activated using optogenetics. Our data indicate that basal ganglia-thalamic inputs modulate thalamocortical activity through both GABAergic inhibition and following rebound excitation and control voluntary movements, and that cerebellar inputs induce thalamocortical activity at accurate timing for fine and accurate movement control.

Academic Significance and Societal Importance of the Research Achievements

大脳基底核出力が運動を制御する機構は脱抑制説によって説明されているが、上肢運動系にもあてはまるのかは検証されていない。したがって、大脳基底核から視床への情報伝達が抑制とリバウンド興奮によることが示されたことは、大脳基底核の運動制御機構を理解する上で大きな進展である。また、本研究により大脳基底核出力と小脳出力が視床-大脳皮質投射を制御するメカニズムを明らかにしたことは、大脳基底核と小脳による運動制御機構の理解に大きく貢献できたと考えられる。さらに、本研究の成果は運動障害疾患の病態解明と、効果的な治療法の開発にもつながるものと考えられるため、社会的意義も大きい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2019 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (15 results) (of which Int'l Joint Research: 11 results,  Invited: 10 results)

  • [Journal Article] MechanismDeep Brain Stimulation: Inhibition, Excitation or Disruption?2015

    • Author(s)
      Chiken S, Nambu A
    • Journal Title

      Neuroscientist

      Volume: in press Issue: 3 Pages: 313-322

    • DOI

      10.1177/1073858415581986

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] How does the cerebellum control thalamocortical activity?2019

    • Author(s)
      Chiken S, Sano H, Kobayashi K, Nambu A
    • Organizer
      9th FAOPS Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cerebellar control of thalamocortical activity.2018

    • Author(s)
      Chiken S, Sano H, Kobayashi K, Nambu A
    • Organizer
      FENS Forum 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] モデルマウスの神経活動からジストニアの病態生理を探る.2018

    • Author(s)
      知見聡美、南部篤
    • Organizer
      第33回日本大脳基底核研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] How do the basal ganglia and cerebellum control thalamocortical activity?2018

    • Author(s)
      Chiken S
    • Organizer
      8th Joint CIN-NIPS Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The chemogenetic suppression of the primate subthalamic nucleus impairs voluntary movements by disturbing the firing pattern in the internal segment of the globus pallidus.2018

    • Author(s)
      Hasegawa T, Chiken S, Kobayashi K, Nambu A
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Abnormal incormation flow through the cortico-basal ganglia pathways in MPTP-treated parkinsonian monkeys.2017

    • Author(s)
      Satomi Chiken, Atsushi Nambu
    • Organizer
      12th International Basal Ganglia Society Meeting IBAGS-XII
    • Place of Presentation
      Fiesta Americana (メキシコ メリダ)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Parkinson's diseasse as a network disorder2017

    • Author(s)
      Satomi Chiken
    • Organizer
      International symposium, Neural Oscillation Conference 2017, Problems of Consciousness and Neuropsychiatric Disorders as Network Diseases
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] How do the basal ganglia and cerebellum control thalamocortical activity?2017

    • Author(s)
      Satomi Chiken, Atsushi Nambu
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscicence Society
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] How do the basal ganglia and cerebellum control thalamocortical activity?2017

    • Author(s)
      Satomi Chiken, Atsushi Nambu
    • Organizer
      International Workshop on Basal Ganglia Functions 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 大脳皮質-大脳基底核ループとパーキンソン病2017

    • Author(s)
      知見聡美、南部篤
    • Organizer
      生理研研究会「脳の階層的理解を目指して」
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Basal ganglia and cerebellar control of tharamocortical activity2017

    • Author(s)
      Satomi Chiken, Atsushi Nambu
    • Organizer
      7th NIPS-CIN Joint Symosium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Basal ganglia & cerebellar control of thalamocortical activity.2016

    • Author(s)
      Satomi Chiken
    • Organizer
      Stockholm-Okazaki Symposium “Multi-scale structures & dynamics of the basal ganglia”
    • Place of Presentation
      SciLife Labs (スウェーデン ストックホルム)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] How do the basal ganglia control thalamocortical activity?2016

    • Author(s)
      Satomi Chiken, Atsushi Nambu
    • Organizer
      Satellite Symposium of Neuroscience 2016 “Basal Ganglia in Health and Disease”
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dopaminergic transmission maintains dynamic activity changes in the basal ganglia to appropriately control movements.2016

    • Author(s)
      Satomi Chiken, Atsushi Nambu
    • Organizer
      39th Annual Meeting of the Japan Neuroscience Society Symposium
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] パーキンソン病の病態生理:モデルサルにおける神経活動の記録。2016

    • Author(s)
      知見聡美、南部篤
    • Organizer
      名古屋大学・生理学研究所合同シンポジウム
    • Place of Presentation
      名古屋大学(愛知県 名古屋)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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