| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To understand how the basal ganglia and cerebellum control voluntary movements, we recorded thalamocortical activity during performance of a hand reaching task in macaque monkeys. Basal ganglia-thalamic inputs and cerebello-thalamic inputs were selectively blocked or activated using optogenetics. Our data indicate that basal ganglia-thalamic inputs modulate thalamocortical activity through both GABAergic inhibition and following rebound excitation and control voluntary movements, and that cerebellar inputs induce thalamocortical activity at accurate timing for fine and accurate movement control.
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