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Construction of a mouse template brain with variable annotation numbers from 1 to 860

Research Project

Project/Area Number 16K07032
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKeio University

Principal Investigator

Takata Norio  慶應義塾大学, 医学部(信濃町), 特任講師 (50415212)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords標準脳 / テンプレート / Allen / brain / 関心領域 / MRI / fMRI / mouse / マウス / 脳 / アレン / ROI / BOLD / 解剖学的階層性
Outline of Final Research Achievements

In magnetic resonance imaging (MRI) of the human brain, there is a standard brain in which brain region names correspond to brain coordinates. However, there is no practical one in the mouse brain. Region of interest (ROI) has been arbitrary and reproduction of other researchers' ROIs were difficult. Allen Institute released 3D-reconstruction data of the mouse brain in 2015. This study aimed to make it available for MRI analysis. As a result, we constructed a flexible template of the mouse brain. The total number of brain regions is variable according to the research purpose. New ROIs can be prepared using gene expression and neuro-projection data provided by the Allen Institute. Sharing among researchers is straightforward.

Academic Significance and Societal Importance of the Research Achievements

MRIを用いた脳研究では標準脳の整備が重要である。被験者ごとに異なる形態を示す脳の活動を比較するために用いるからである。ヒト脳ではこれが整備されているが、マウス脳では存在しなかった。本研究は脳部位数を柔軟に変更できるマウス標準脳の作成方法を構築した。研究目的ごとに最適な脳部位数を備えるマウス標準脳が利用可能となった。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2019 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results)

  • [Journal Article] Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation2018

    • Author(s)
      Norio Takata, Yuki Sugiura, Keitaro Yoshida, Miwako Koizumi, Hiroshi Nishida, Kurara Honda, Ryutaro Yano, Yuji Komaki, Ko Matsui, Makoto Suematsu , Masaru Mimura, Hideyuki Okano, Kenji F. Tanaka
    • Journal Title

      Glia

      Volume: 印刷中 Issue: 9 Pages: 2013-2023

    • DOI

      10.1002/glia.23454

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visualization of myelinated fiber bundles orientation during brain slice preparation by reflection polarized light microscopy2018

    • Author(s)
      Takata Norio、Kusayanagi Kohei、Maruyama Hironori、Eitai Kenji、Abo Masaaki、Akiyama Fumihiko、Tajima Ryo、Inaba Shinsuke、Tanaka Kenji F.、Mimura Masaru、Sanaka Kaoru
    • Journal Title

      Microscopy Research and Technique

      Volume: 81 Issue: 12 Pages: 1366-1373

    • DOI

      10.1002/jemt.23077

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity.2017

    • Author(s)
      Akiyo Natsubori, Iku Tsustui-Kimura, Hiroshi Nishida, Youcef Bouchekioua, Hiroshi Sekiya, Motokazu Uchigashima, Masahiko Watanabe, Alban de Kerchove d'Exaerde, Masaru Mimura, Norio Takata, and Kenji Tanaka
    • Journal Title

      Journal of Neuroscience

      Volume: 37 Issue: 10 Pages: 2723-2733

    • DOI

      10.1523/jneurosci.3377-16.2017

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation.2017

    • Author(s)
      Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF.
    • Journal Title

      Nat Commun.

      Volume: 8 Issue: 1 Pages: 14304-14304

    • DOI

      10.1038/ncomms14304

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe2016

    • Author(s)
      Keitaro Yoshida, Yu Mimura, Ryosuke Ishihara, Hiroshi Nishida, Yuji Komaki, Tomohito Minakuchi, Tomokazu Tsurugizawa, Masaru Mimura, Hideyuki Okano, Kenji F. Tanaka, Norio Takata
    • Journal Title

      J Neurosci Methods.

      Volume: 274 Pages: 38-48

    • DOI

      10.1016/j.jneumeth.2016.09.013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 視床を抑制する視床網様核の新規振動活動は安静時の全脳活動を規定する2019

    • Author(s)
      高田則雄
    • Organizer
      第42回日本神経科学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Causal evidence of BOLD-fMRI signal generation by astrocytes without neuronal activation2019

    • Author(s)
      高田則雄
    • Organizer
      The 2nd FRIS-TFC Joint Symposium: Unlocking the Brain from Engineering Approaches
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 視床を抑制する視床網様核の集合Ca2+活動は新規発振現象を示す2018

    • Author(s)
      高田則雄、夏堀晃世、三村將、田中謙二
    • Organizer
      第41回日本神経科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 光遺伝学的fMRIを用いた海馬活動伝播様式の全脳解析2017

    • Author(s)
      高田則雄
    • Organizer
      次世代プロジェクト「異なる時期の虚血が脳の発達に及ぼす影響の多層的アプローチによる解明と治療戦略構築」国際シンポジウム
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dissection of downstream targets of the hippocampus using optogenetic fMRI2017

    • Author(s)
      高田則雄
    • Organizer
      次世代プロジェクト「異なる時期の虚血が脳の発達に及ぼす影響の多層的アプローチによる解明と治療戦略構築」国際シンポジウム
    • Place of Presentation
      慶応義塾大学医学部
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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